Phenotypes associated with this allele

• Allele Symbol: F8^tm2Kaz
• Allele Name: targeted mutation 2, Haig H Kazazian Jr
• Allele ID: MGI:2179968
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	F8^tm2Kaz/Y Tg(Alb-F8)EBmre/0	involves: 129S4/SvJae * C57BL/6J	MGI:5297961
ot2	F8^tm2Kaz/Y	involves: 129S4/SvJae	MGI:5297962
ot3	F8^tm2Kaz/Y	involves: 129S4/SvJae * C57BL/6	MGI:2449546

Genotype
MGI:5297961

cx1

• Allelic Composition: F8^tm2Kaz/Y; Tg(Alb-F8)EBmre/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal blood coagulation ( J:176909 )

♂ • after tail cut, blood loss is greater than in wild-type mice

Genotype
MGI:5297962

ot2

• Allelic Composition: F8^tm2Kaz/Y
• Genetic Background: involves: 129S4/SvJae

homeostasis/metabolism

abnormal blood coagulation ( J:176909 )

♂ • after tail cut, blood loss is greater than in wild-type mice

Genotype
MGI:2449546

ot3

• Allelic Composition: F8^tm2Kaz/Y
• Genetic Background: involves: 129S4/SvJae * C57BL/6

homeostasis/metabolism

abnormal blood coagulation ( J:24941 , J:36698 )

♂ • males exhibit hemophilia (J:24941)

♂ • mice exhibit a reduced ability to clot blood upon tail cutting, with most animals dying within 2 hours of tail snipping unless cauterized; however, no spontaneous bleeding is observed into joints or soft tissues up to 12 weeks of age (J:24941)

♂ • plasma from mutant mice exhibits a prolonged clotting time compared to controls (J:24941)

♂ • females exhibit normal fertility and pregnancy (J:36698)

♂ • males exhibit no spontaneous bleeding, illness or reduction in activity up to 1 year of age (J:36698)

♂ • 2/3 males die within 2 hours of tail snipping from excessive bleeding (J:36698)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
factor VIII deficiency		DOID:12134	OMIM:306700	J:24941