About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Xrcc5tm1Dbr
targeted mutation 1, David B Roth
MGI:2179987
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Xrcc5tm1Dbr/Xrcc5tm1Dbr involves: 129S1/Sv * C57BL/6 MGI:3639043
hm2
 		Xrcc5tm1Dbr/Xrcc5tm1Dbr involves: 129S6/SvEvTac * C57BL/6 MGI:3655990
hm3
 		Xrcc5tm1Dbr/Xrcc5tm1Dbr Not Specified MGI:5013937
ht4
 		Xrcc5tm1Dbr/Xrcc5+ involves: 129S6/SvEvTac * C57BL/6 MGI:3655989
cx5
 		Xrcc5tm1Dbr/Xrcc5+
Lig4tm1Fwa/Lig4+ 		involves: 129S6/SvEvTac * C57BL/6 MGI:3655987
cx6
 		Xrcc5tm1Dbr/Xrcc5tm1Dbr
Lig4tm1Fwa/Lig4tm1Fwa 		involves: 129S6/SvEvTac * C57BL/6 MGI:3655986
cx7
 		Rag1tm1Mom/Rag1tm1Mom
Xrcc5tm1Dbr/Xrcc5tm1Dbr 		involves: 129S7/SvEvBrd * C57BL MGI:3818750
cx8
 		Trp53tm1Brd/Trp53tm1Brd
Xrcc5tm1Dbr/Xrcc5tm1Dbr 		involves: 129S7/SvEvBrd * C57BL MGI:3818751
cx9
 		Rag1tm1Mom/Rag1tm1Mom
Trp53tm1Brd/Trp53tm1Brd
Xrcc5tm1Dbr/Xrcc5tm1Dbr 		involves: 129S7/SvEvBrd * C57BL MGI:3818748


Genotype
MGI:3639043
hm1
Allelic
Composition		 Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xrcc5tm1Dbr mutation (0 available); any Xrcc5 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
thymus hypoplasia ( J:34834 )
• mice have a profoundly hypocellular thymus with 50- 170-fold fewer cells than controls
abnormal B cell differentiation ( J:34834 )
• mice display defective coding joint formation; Ig heavy chain rearrangements are decreased by ~10-fold compared to wild-type
• mice display defective signal joint formation
arrested B cell differentiation ( J:34834 )
• B cells development is arrested at at the pro-B cell stage
increased double-negative T cell number ( J:34834 )
• over 90% of thymocytes are double-negative compared to only 5-10% of wild-type
arrested T cell differentiation ( J:34834 )
• thymocytes from 10 week-old mice are arrested at the CD4-CD8-CD25+ stage
absent T cells ( J:34834 )
• no mature T cells are detected in mutants
lymph node hypoplasia ( J:34834 )
• lymph nodes are hypocellular and difficult to recover

hematopoietic system
thymus hypoplasia ( J:34834 )
• mice have a profoundly hypocellular thymus with 50- 170-fold fewer cells than controls
abnormal B cell differentiation ( J:34834 )
• mice display defective coding joint formation; Ig heavy chain rearrangements are decreased by ~10-fold compared to wild-type
• mice display defective signal joint formation
arrested B cell differentiation ( J:34834 )
• B cells development is arrested at at the pro-B cell stage
increased double-negative T cell number ( J:34834 )
• over 90% of thymocytes are double-negative compared to only 5-10% of wild-type
arrested T cell differentiation ( J:34834 )
• thymocytes from 10 week-old mice are arrested at the CD4-CD8-CD25+ stage
absent T cells ( J:34834 )
• no mature T cells are detected in mutants

vision/eye
increased retina apoptosis ( J:86825 )
• embryonic mice show increased (~5-fold) retinal apoptosis compared to wild-type
abnormal retina morphology ( J:86825 )
• number of neuronal retinal nuclei is decreased compare to wild-type when quantified between 2 and 8 months of age

cellular
increased retina apoptosis ( J:86825 )
• embryonic mice show increased (~5-fold) retinal apoptosis compared to wild-type

endocrine/exocrine glands
thymus hypoplasia ( J:34834 )
• mice have a profoundly hypocellular thymus with 50- 170-fold fewer cells than controls




Genotype
MGI:3655990
hm2
Allelic
Composition		 Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xrcc5tm1Dbr mutation (0 available); any Xrcc5 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:80467 )
N
• a small number of Lig4+/+, Xrcc5tm1Dbr null animals (4/131) have reached maturity and are viable; this is equivalent to observed viability of Xrcc5-null animals
prenatal lethality, incomplete penetrance ( J:80467 )
• some Lig4 +/+/Xrcc5-null animals have been live born compared to total lethality of Lig4 single null animals

cellular
chromosome breakage ( J:80467 )
• numbers of cultured cells show a higher percentage of chromosome aberrations than wild-type cells (~60% vs ~10%)




Genotype
MGI:5013937
hm3
Allelic
Composition		 Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xrcc5tm1Dbr mutation (0 available); any Xrcc5 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased neuron apoptosis ( J:110848 )
• in the spinal cord at E12.5

cellular
increased neuron apoptosis ( J:110848 )
• in the spinal cord at E12.5




Genotype
MGI:3655989
ht4
Allelic
Composition		 Xrcc5tm1Dbr/Xrcc5+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xrcc5tm1Dbr mutation (0 available); any Xrcc5 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
chromosome breakage ( J:80467 )
• ~20% of heterozygous cells in culture exhibit chromosomal instability




Genotype
MGI:3655987
cx5
Allelic
Composition		 Xrcc5tm1Dbr/Xrcc5+
Lig4tm1Fwa/Lig4+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4tm1Fwa mutation (2 available); any Lig4 mutation (46 available)
Xrcc5tm1Dbr mutation (0 available); any Xrcc5 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
chromosome breakage ( J:80467 )
• cultured fibroblasts display chromosomal instability at a level of ~32%, similar to heterozygous Lig4 fibroblasts




Genotype
MGI:3655986
cx6
Allelic
Composition		 Xrcc5tm1Dbr/Xrcc5tm1Dbr
Lig4tm1Fwa/Lig4tm1Fwa
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4tm1Fwa mutation (2 available); any Lig4 mutation (46 available)
Xrcc5tm1Dbr mutation (0 available); any Xrcc5 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:80467 )
N
• a small number of tm1Fwa, Xrcc5tm1Dbr null animals (4/131) have reached maturity and are viable; this is equivalent to observed viability of Xrcc5-null animals
prenatal lethality, incomplete penetrance ( J:80467 )
• 4/131 Lig4/Xrcc5 double null animals have been live born compared to total lethality of Lig4 single null animals

immune system
abnormal lymphocyte morphology ( J:80467 )
• double mutants show lymphoid depletion similar to that observed in Xrcc5-deficient mice

hematopoietic system
abnormal lymphocyte morphology ( J:80467 )
• double mutants show lymphoid depletion similar to that observed in Xrcc5-deficient mice

digestive/alimentary system
abnormal small intestine morphology ( J:80467 )
• small intestines show smaller villi relative to wild-type and Xrcc5-deficient mice

cellular
chromosome breakage ( J:80467 )
• numbers of cultured cells show similar total percentage of chromosome aberrations to Xrcc4-deficient cells (~60% vs ~10% of wild-type cells)




Genotype
MGI:3818750
cx7
Allelic
Composition		 Rag1tm1Mom/Rag1tm1Mom
Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (49 available); any Rag1 mutation (123 available)
Xrcc5tm1Dbr mutation (0 available); any Xrcc5 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased cerebellar granule cell number ( J:141515 )
• mice exhibit a focal increase in external granule cells compared to in wild-type mice

neoplasm
neoplasm ( J:141515 )
N
• despite the increase in granule cells, mice do not develop medulloblastoma




Genotype
MGI:3818751
cx8
Allelic
Composition		 Trp53tm1Brd/Trp53tm1Brd
Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Brd mutation (5 available); any Trp53 mutation (240 available)
Xrcc5tm1Dbr mutation (0 available); any Xrcc5 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:141515 )
• median lifespan is 7 weeks
• maximum lifespan is 16 weeks

neoplasm
increased lymphoma incidence ( J:141515 )
• in 8 of 13 mice

nervous system




Genotype
MGI:3818748
cx9
Allelic
Composition		 Rag1tm1Mom/Rag1tm1Mom
Trp53tm1Brd/Trp53tm1Brd
Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (49 available); any Rag1 mutation (123 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (240 available)
Xrcc5tm1Dbr mutation (0 available); any Xrcc5 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:141515 )
• median lifespan is 14 weeks compared to 7 weeks in Trp53tm1Brd Xrcc5tm1Dbr
• maximum lifespan is 20 weeks compared to 16 weeks in Trp53tm1Brd Xrcc5tm1Dbr

neoplasm
increased stomach tumor incidence ( J:141515 )
• one mouse developed a stomach neoplasm
increased T cell derived lymphoma incidence ( J:141515 )
• 55% mice develop T cell lymphomas in the liver, spleen, lymph nodes, bone marrow, kidney, heart, lungs and ovaries
increased medulloblastoma incidence ( J:141515 )
• mice that exhibit vertigo develop medulloblastoma
• 66.7% of mice exhibit medulloblastoma at the time of morbidity

respiratory system
respiratory distress ( J:141515 )
• one-fifth of mice exhibit labored breathing prior to death compared to two-thirds of Rag1tm1Mom Trp53tm1Brd

behavior/neurological
impaired balance ( J:141515 )
• two-thirds of mice exhibit an acute onset of vertigo that leads to disabled mobility and severe dehydration as a result of inability to reach the water source

homeostasis/metabolism
dehydration ( J:141515 )
• two-thirds of mice exhibit an acute onset of vertigo that leads to disabled mobility and severe dehydration as a result of inability to reach the water source

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:141515 )
• 55% mice develop T cell lymphomas in the liver, spleen, lymph nodes, bone marrow, kidney, heart, lungs and ovaries

nervous system
increased medulloblastoma incidence ( J:141515 )
• mice that exhibit vertigo develop medulloblastoma
• 66.7% of mice exhibit medulloblastoma at the time of morbidity

digestive/alimentary system
increased stomach tumor incidence ( J:141515 )
• one mouse developed a stomach neoplasm

immune system
increased T cell derived lymphoma incidence ( J:141515 )
• 55% mice develop T cell lymphomas in the liver, spleen, lymph nodes, bone marrow, kidney, heart, lungs and ovaries

hematopoietic system
increased T cell derived lymphoma incidence ( J:141515 )
• 55% mice develop T cell lymphomas in the liver, spleen, lymph nodes, bone marrow, kidney, heart, lungs and ovaries

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
medulloblastoma DOID:0050902 OMIM:155255
 J:141515




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory