All Phenotypes Tg(Cga-cre)3Sac MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nr5a1^tm2Klp/Nr5a1^tm2.1Klp Tg(Cga-cre)3Sac/0	involves: 129P2/OlaHsd * C57BL/6J * SJL	MGI:2180104
cn2	Nr5a1^tm2Klp/Nr5a1^tm2Klp Tg(Cga-cre)3Sac/0	involves: 129P2/OlaHsd * C57BL/6J * SJL	MGI:2180121
cn3	Gata2^tm1Sac/Gata2^tm1Sac Tg(Cga-cre)3Sac/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL	MGI:3639705
cn4	Esr1^tm1.2Mma/Esr1^tm1.2Mma Tg(Cga-cre)3Sac/0	involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL	MGI:3798388
cn5	Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr Tg(Cga-cre)3Sac/0	involves: 129S7/SvEvBrd * C57BL/6 * SJL	MGI:3819176
cn6	Dio2^tm1Acb/Dio2^tm1Acb Tg(Cga-cre)3Sac/0	involves: C57BL/6J * SJL	MGI:5513867
cn7	Foxl2^tm2.1Tre/Foxl2^tm2.1Tre Tg(Cga-cre)3Sac/0	involves: C57BL/6 * SJL	MGI:4430333

Allelic Composition	Nr5a1^tm2Klp/Nr5a1^tm2.1Klp Tg(Cga-cre)3Sac/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr5a1^tm2.1Klp mutation (0 available); any Nr5a1 mutation (30 available)
Nr5a1^tm2Klp mutation (2 available); any Nr5a1 mutation (30 available)
Tg(Cga-cre)3Sac mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

prostate gland hypoplasia ( J:66593 )

• treatment with exogenous gonadotropins stimulated enlargement of the hypoplastic prostate glands

seminal vesicle hypoplasia ( J:66593 )

• treatment with exogenous gonadotropins stimulated enlargement of the hypoplastic seminal vesicles

absent corpus luteum ( J:66593 )

absent mature ovarian follicles ( J:66593 )

• although ovarian follicles develop through the primary, secondary and antral stages, no large preovulatory follicles or corpora lutea are observed

• treatment with exogenous gonadotropins (PMSG) stimulated maturation of ovarian follicles to the preovulatory stage and induced ovulation, as indicated by the presence of corpora lutea

ovary hypoplasia ( J:66593 )

• severe

abnormal Leydig cell morphology ( J:66593 )

• mutant Leydig cells display none of the histological features typical of steroidogenic cells

decreased Leydig cell number ( J:66593 )

• interstitial Leydig cells are severely reduced in number

• treatment with exogenous gonadotropins stimulated Leydig cell hypertrophy and induced luminal opening of the seminiferous tubules

testis hypoplasia ( J:66593 )

• severe

cryptorchism ( J:66593 )

• mutant males have cryptorchid testes

reproductive system

decreased male germ cell number ( J:66593 )

• male germ cells are significantly reduced in number

abnormal female reproductive system morphology ( J:66593 )

absent corpus luteum ( J:66593 )

absent mature ovarian follicles ( J:66593 )

• although ovarian follicles develop through the primary, secondary and antral stages, no large preovulatory follicles or corpora lutea are observed

• treatment with exogenous gonadotropins (PMSG) stimulated maturation of ovarian follicles to the preovulatory stage and induced ovulation, as indicated by the presence of corpora lutea

uterus hypoplasia ( J:66593 )

• treatment with exogenous gonadotropins (PMSG) stimulated a significant increase in uterine size and development of the endometrial glands

abnormal spermatogenesis ( J:66593 )

• mutant males fail to progress through the normal stages of spermatogenesis: occasional pachytene spermatocytes are observed, but mature spermatids are absent

• treatment with exogenous gonadotropins (PMSG) stimulated gonadal steroidogenesis, inducing maturation of spermatogonial precursors to the round spermatid stage

abnormal spermatid morphology ( J:66593 )

• no mature spermatids are observed

abnormal male reproductive system morphology ( J:66593 )

• mutant males show hypoplastic external and internal genitalia

prostate gland hypoplasia ( J:66593 )

• treatment with exogenous gonadotropins stimulated enlargement of the hypoplastic prostate glands

seminal vesicle hypoplasia ( J:66593 )

• treatment with exogenous gonadotropins stimulated enlargement of the hypoplastic seminal vesicles

abnormal Leydig cell morphology ( J:66593 )

• mutant Leydig cells display none of the histological features typical of steroidogenic cells

decreased Leydig cell number ( J:66593 )

• interstitial Leydig cells are severely reduced in number

• treatment with exogenous gonadotropins stimulated Leydig cell hypertrophy and induced luminal opening of the seminiferous tubules

cryptorchism ( J:66593 )

• mutant males have cryptorchid testes

external male genitalia hypoplasia ( J:66593 )

internal male genitalia hypoplasia ( J:66593 )

small gonad ( J:66593 )

• mutant gonads are severely hypoplastic

ovary hypoplasia ( J:66593 )

• severe

testis hypoplasia ( J:66593 )

• severe

delayed vaginal opening ( J:66593 )

• mutant vaginas fail to open at the normal age of puberty

absent sexual maturation ( J:66593 )

• both male and female mutants are viable but fail to show signs of secondary sexual maturation, even at 6 months of age

• both male and female mutants exhibit sexual infantilism of the accessory sex organs

anovulation ( J:66593 )

female infertility ( J:66593 )

male infertility ( J:66593 )

homeostasis/metabolism

decreased follicle stimulating hormone level ( J:66593 )

• although mutant pituitaries appear histologically intact, immunoreactive FSH leves are virtually undetectable

• in contrast, pituitary ACTH, TSH and prolactin levels are comparable to those in wild-type pituitaries

decreased circulating follicle stimulating hormone level ( J:66593 )

• serum FSH levels are significantly reduced in both male and female mutants relative to wild-type controls

decreased luteinizing hormone level ( J:66593 )

• although mutant pituitaries appear histologically intact, immunoreactive LH leves are virtually undetectable

decreased circulating luteinizing hormone level ( J:66593 )

• serum LH levels are significantly reduced in male mutants relative to wild-type controls

cellular

abnormal spermatid morphology ( J:66593 )

• no mature spermatids are observed

decreased male germ cell number ( J:66593 )

• male germ cells are significantly reduced in number

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hypogonadotropic hypogonadism		DOID:0090070	OMIM:PS147950	J:66593

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal sex gland morphology ( J:70412 )

prostate gland hypoplasia ( J:70412 )

• similar to that observed in mice that are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac

seminal vesicle hypoplasia ( J:70412 )

• similar to that observed in mice that are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac

absent corpus luteum ( J:70412 )

absent mature ovarian follicles ( J:70412 )

• neither large preovulatory follicles nor corpora lutea are observed, similar to mice that are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac

impaired ovarian folliculogenesis ( J:70412 )

• mutant mice display absence of follicular maturation beyond the antral stage

small ovary ( J:70412 )

• although mutant ovaries are smaller than wild-type, they are significantly larger than those of mice that are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac

decreased ovary weight ( J:70412 )

• at 8 weeks of age, the weight of mutant ovaries (0.06 g/kg) is significantly lower than wild-type (0.47 g/kg), but higher than that of mice which are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac (0.01 g/kg)

decreased Leydig cell number ( J:70412 )

• at 8 weeks of age, mutant interstitial Leydig cells are severely hypoplastic

• in contrast, Sertoli cells and developing germ cells (including mature sperm) are relatively intact

small testis ( J:70412 )

• although mutant testes are smaller than wild-type, they are significantly larger than those of mice that are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac

decreased testis weight ( J:70412 )

• at 8 weeks of age, the weight of mutant testes (3.7 g/kg) is significantly lower than wild-type (7.9 g/kg), but significantly higher than that of mice which are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac (0.4 g/kg)

uterus hypoplasia ( J:70412 )

• similar to that observed in mice that are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac

small gonad ( J:70412 )

• both male and female mutants show a milder degree of (hypomorphic) hypogonadism than mice that are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac

absent sexual maturation ( J:70412 )

• both male and female mutants show little evidence for secondary sexual maturation

female infertility ( J:70412 )

male infertility ( J:70412 )

endocrine/exocrine glands

abnormal sex gland morphology ( J:70412 )

prostate gland hypoplasia ( J:70412 )

• similar to that observed in mice that are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac

seminal vesicle hypoplasia ( J:70412 )

• similar to that observed in mice that are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac

absent corpus luteum ( J:70412 )

absent mature ovarian follicles ( J:70412 )

• neither large preovulatory follicles nor corpora lutea are observed, similar to mice that are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac

impaired ovarian folliculogenesis ( J:70412 )

• mutant mice display absence of follicular maturation beyond the antral stage

small ovary ( J:70412 )

• although mutant ovaries are smaller than wild-type, they are significantly larger than those of mice that are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac

decreased ovary weight ( J:70412 )

decreased Leydig cell number ( J:70412 )

• at 8 weeks of age, mutant interstitial Leydig cells are severely hypoplastic

• in contrast, Sertoli cells and developing germ cells (including mature sperm) are relatively intact

small testis ( J:70412 )

• although mutant testes are smaller than wild-type, they are significantly larger than those of mice that are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac

decreased testis weight ( J:70412 )

homeostasis/metabolism

decreased circulating follicle stimulating hormone level ( J:70412 )

• mutant mice of both sexes show circulating FSH levels (4.5 ng/ml males, 5.2 ng/ml females) that are intermediate between those of wild-type mice (31.35 ng/ml males, 12.4 ng/ml females) and mice that are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac (1.2 ng/ml males, 2.7 ng/ml females)

decreased circulating luteinizing hormone level ( J:70412 )

• mutant males display a severe reduction in circulating LH levels similar to that observed in mice that are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac

behavior/neurological

abnormal sexual interaction ( J:70412 )

• mutants do not engage in sexual activity

Allelic Composition	Gata2^tm1Sac/Gata2^tm1Sac Tg(Cga-cre)3Sac/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata2^tm1Sac mutation (1 available); any Gata2 mutation (30 available)
Tg(Cga-cre)3Sac mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pituitary gland development ( J:108963 )

• fewer thyrotrope and gonadotrope in neonates

• thyrotrope population recover in adult

decreased seminal vesicle weight ( J:108963 )

• weights approximately 55% that of wild-type

abnormal pituitary secretion ( J:108963 )

• inability to increases TSH production and secretion in response to severe hypothyroidism induced by radiothyroidectomy

nervous system

abnormal pituitary gland development ( J:108963 )

• fewer thyrotrope and gonadotrope in neonates

• thyrotrope population recover in adult

abnormal pituitary secretion ( J:108963 )

• inability to increases TSH production and secretion in response to severe hypothyroidism induced by radiothyroidectomy

homeostasis/metabolism

decreased circulating follicle stimulating hormone level ( J:108963 )

• 28% of that found in wild-type

decreased circulating thyroid-stimulating hormone level ( J:108963 )

• in the male at 56% the level of wild-type

reproductive system

decreased seminal vesicle weight ( J:108963 )

• weights approximately 55% that of wild-type

growth/size/body

postnatal growth retardation ( J:108963 )

• beginning at 3 weeks of age, the male mutant begin to show growth insufficiency

Allelic Composition	Esr1^tm1.2Mma/Esr1^tm1.2Mma Tg(Cga-cre)3Sac/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esr1^tm1.2Mma mutation (0 available); any Esr1 mutation (68 available)
Tg(Cga-cre)3Sac mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

ovarian follicular cyst ( J:131949 )

• occasionally follicular cysts are observed in mice

abnormal estrous cycle ( J:131949 )

• irregular cycling

female infertility ( J:131949 )

endocrine/exocrine glands

ovarian follicular cyst ( J:131949 )

• occasionally follicular cysts are observed in mice

growth/size/body

ovarian follicular cyst ( J:131949 )

• occasionally follicular cysts are observed in mice

Allelic Composition	Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr Tg(Cga-cre)3Sac/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr1a^tm1Bhr mutation (1 available); any Bmpr1a mutation (90 available)
Bmpr1a^tm2.1Bhr mutation (1 available); any Bmpr1a mutation (90 available)
Tg(Cga-cre)3Sac mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:121318 )

• occurs at E12.5 likely due to heart defects

embryo

decreased embryo size ( J:121318 )

• embryos are smaller than wild-type littermates at prior to lethality

growth/size/body

decreased embryo size ( J:121318 )

• embryos are smaller than wild-type littermates at prior to lethality

endocrine/exocrine glands

abnormal pituitary gland development ( J:121318 )

abnormal Rathke's pouch development ( J:121318 )

• at E10.5 pouch is thin and underdeveloped compared to wild-type littermates

nervous system

abnormal pituitary gland development ( J:121318 )

abnormal Rathke's pouch development ( J:121318 )

• at E10.5 pouch is thin and underdeveloped compared to wild-type littermates

cardiovascular system

abnormal heart morphology ( J:121318 )

• embryos display heart defects

Allelic Composition	Dio2^tm1Acb/Dio2^tm1Acb Tg(Cga-cre)3Sac/0
Genetic Background	involves: C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dio2^tm1Acb mutation (0 available); any Dio2 mutation (19 available)
Tg(Cga-cre)3Sac mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating thyroid-stimulating hormone level ( J:197623 )

• 2.8-fold

abnormal thyroid hormone level ( J:197623 )

• mice treated with T4 exhibit a lower reduction in serum TSH likely due to impaired T4 to T3 conversion compared with control mice

increased circulating thyroxine level ( J:197623 )

• with elevated free T4 levels

adipose tissue

decreased total body fat amount ( J:197623 )

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:197623 )

N	• mice are systematically euthyroid

Allelic Composition	Foxl2^tm2.1Tre/Foxl2^tm2.1Tre Tg(Cga-cre)3Sac/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxl2^tm2.1Tre mutation (0 available); any Foxl2 mutation (15 available)
Tg(Cga-cre)3Sac mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal ovary morphology ( J:157008 )

• almost entire structure is affected

• instead of normal granulosa cells, cells with morphological characteristics of Sertoli cells (prominent basal lamina, tripartite nuclei, numerous veil-like cytoplasmic extensions pointing toward lumen) are observed

abnormal ovarian follicle morphology ( J:157008 )

• typical follicular structure of ovary resembles seminiferous tubules of testis

abnormal ovary size ( J:157008 )

• size is increased compared to control females

primary sex reversal ( J:157008 )

• female mice exhibit gonadal sex reversal

endocrine/exocrine glands

abnormal ovary morphology ( J:157008 )

• almost entire structure is affected

abnormal ovarian follicle morphology ( J:157008 )

• typical follicular structure of ovary resembles seminiferous tubules of testis

abnormal ovary size ( J:157008 )

• size is increased compared to control females

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