All Phenotypes Lcp2<tm1Gak> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lcp2^tm1Gak/Lcp2^tm1Gak	involves: 129S1/Sv * 129X1/SvJ	MGI:3626256
cn2	Lcp2^tm1Gak/Lcp2^tm2Gak Tg(VAV1-cre)1Graf/0 Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:4843965
cn3	Lcp2^tm1Gak/Lcp2^tm2Gak Tg(Pf4-icre)Q3Rsko/0 Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4843964
cx4	Cbl^tm1.1Hua/Cbl^tm1.1Hua Lcp2^tm1Gak/Lcp2^tm1Gak Rag2^tm1Fwa/Rag2^tm1Fwa	involves: 129P2/OlaHsd * 129S/SvEv * 129S1/Sv * 129X1/SvJ	MGI:3626254
cx5	Cbl^tm1.1Hua/Cbl^tm1.1Hua Lcp2^tm1Gak/Lcp2^tm1Gak	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:3626255

Allelic Composition	Lcp2^tm1Gak/Lcp2^tm1Gak
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lcp2^tm1Gak mutation (1 available); any Lcp2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:91369 )

• there is a selective loss of homozygous progeny observed

hematopoietic system

abnormal platelet activation ( J:162815 )

• platelets fail to activate in response to plating on lymphatic microvascular endothelial cells (LEC) unlike wild-type cells

• platelets from neonates without vascular phenotypes exhibit low levels of convulxin-stimulated fibrinogen binding compared with similarly treated wild-type cells

decreased platelet aggregation ( J:162815 )

• platelets fail to form aggregates on microvascular endothelial cells (LEC) under flow unlike similarly treated wild-type cells

homeostasis/metabolism

abnormal platelet activation ( J:162815 )

• platelets fail to activate in response to plating on lymphatic microvascular endothelial cells (LEC) unlike wild-type cells

• platelets from neonates without vascular phenotypes exhibit low levels of convulxin-stimulated fibrinogen binding compared with similarly treated wild-type cells

decreased platelet aggregation ( J:162815 )

• platelets fail to form aggregates on microvascular endothelial cells (LEC) under flow unlike similarly treated wild-type cells

Allelic Composition	Lcp2^tm1Gak/Lcp2^tm2Gak Tg(VAV1-cre)1Graf/0 Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1(EYFP)Cos mutation (11 available); any Gt(ROSA)26Sor mutation (993 available)
Lcp2^tm1Gak mutation (1 available); any Lcp2 mutation (41 available)
Lcp2^tm2Gak mutation (0 available); any Lcp2 mutation (41 available)
Tg(VAV1-cre)1Graf mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal lymphatic vessel morphology ( J:162815 )

• at E14.5, mice exhibit blood-filled cutaneous lymphatics unlike in wild-type mice

• neonates exhibit blood-filled mesenteric lymphatics unlike in wild-type mice

digestive/alimentary system

intestinal edema ( J:162815 )

homeostasis/metabolism

intestinal edema ( J:162815 )

Allelic Composition	Lcp2^tm1Gak/Lcp2^tm2Gak Tg(Pf4-icre)Q3Rsko/0 Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal Peyer's patch morphology ( J:162815 )

• some mice exhibit blood-filled Peyer patches unlike in wild-type mice

abnormal lymphatic vessel morphology ( J:162815 )

• mice exhibit blood-filled mesenteric and intestinal lymphatic vessels unlike wild-type mice

homeostasis/metabolism

abnormal platelet activation ( J:162815 )

• platelets from neonates without vascular phenotypes exhibit intermediate levels of convulxin-stimulated fibrinogen binding compared with similarly treated wild-type cells

hematopoietic system

abnormal platelet activation ( J:162815 )

• platelets from neonates without vascular phenotypes exhibit intermediate levels of convulxin-stimulated fibrinogen binding compared with similarly treated wild-type cells

Allelic Composition	Cbl^tm1.1Hua/Cbl^tm1.1Hua Lcp2^tm1Gak/Lcp2^tm1Gak Rag2^tm1Fwa/Rag2^tm1Fwa
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbl^tm1.1Hua mutation (0 available); any Cbl mutation (59 available)
Lcp2^tm1Gak mutation (1 available); any Lcp2 mutation (41 available)
Rag2^tm1Fwa mutation (45 available); any Rag2 mutation (119 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal T cell differentiation ( J:91369 )

• no double positive or single positive T cells are detected in triple mutants

immune system

abnormal T cell differentiation ( J:91369 )

• no double positive or single positive T cells are detected in triple mutants

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

enlarged spleen ( J:91369 )

• mice develop progressive splenomegaly with age and die at ~6 months of age: mutants have 8-12 times the number of splenic CD4+ cells compared to wild-type

abnormal T cell differentiation ( J:91369 )

• double knockouts generate significant proportions of double positive and Cd4+CD8- T cells compared to Lcp knockouts; these populations are significantly lower than those expected in wild-type or Cbl-null mice

• expression of CD3 or Tcrb is decreased on thymic CD4+CD8- cells compared to wild-type cells; expression of CD4 and CD69 is increased on double positive and single positive CD4 thymocytes relative to wild-type

increased CD4-positive, alpha-beta T cell number ( J:91369 )

• mutants have elevated levels of CD4+ T cells in the spleen and lymph nodes of 6 week old mice compared to wild-type or Cbl-null mice; numbers are ~10x the number observed in wild-type or Cbl-null mice at 24 weeks of age

abnormal cytokine secretion ( J:91369 )

• many more CD4+ cells produce Il-2, Il-4 and Ifng compared to wild-type

liver inflammation ( J:91369 )

• extensive lymphocyte infiltration is observed in the liver of mutants; lymphocytes are observed as clusters around hepatic parenchyma

lung inflammation ( J:91369 )

• extensive lymphocyte infiltration is observed in the lungs of mutants; lymphocytes are observed as clusters around pulmonary vessels and bronchioles

hematopoietic system

enlarged spleen ( J:91369 )

• mice develop progressive splenomegaly with age and die at ~6 months of age: mutants have 8-12 times the number of splenic CD4+ cells compared to wild-type

abnormal T cell differentiation ( J:91369 )

increased CD4-positive, alpha-beta T cell number ( J:91369 )

liver/biliary system

liver inflammation ( J:91369 )

• extensive lymphocyte infiltration is observed in the liver of mutants; lymphocytes are observed as clusters around hepatic parenchyma

respiratory system

lung inflammation ( J:91369 )

• extensive lymphocyte infiltration is observed in the lungs of mutants; lymphocytes are observed as clusters around pulmonary vessels and bronchioles

growth/size/body

enlarged spleen ( J:91369 )

• mice develop progressive splenomegaly with age and die at ~6 months of age: mutants have 8-12 times the number of splenic CD4+ cells compared to wild-type

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