Phenotypes associated with this allele

• Allele Symbol: Stk11^tm1Mmt
• Allele Name: targeted mutation 1, Makoto M Taketo
• Allele ID: MGI:2180012
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stk11^tm1Mmt/Stk11^tm1Mmt	involves: 129X1/SvJ	MGI:3851986
ht2	Stk11^tm1Mmt/Stk11^+	involves: 129X1/SvJ	MGI:3851987
cx3	Stk11^tm1Mmt/Stk11^+ Trp53^tm1Brd/Trp53^tm1Brd	involves: 129S7/SvEvBrd * 129X1/SvJ	MGI:3851991
cx4	Stk11^tm1Mmt/Stk11^+ Trp53^tm1Brd/Trp53^+	involves: 129S7/SvEvBrd * 129X1/SvJ	MGI:3851992

Genotype
MGI:3851986

hm1

• Allelic Composition: Stk11^tm1Mmt/Stk11^tm1Mmt
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:76202 )

• no pups are recovered indicating embryonic lethality

Genotype
MGI:3851987

ht2

• Allelic Composition: Stk11^tm1Mmt/Stk11⁺
• Genetic Background: involves: 129X1/SvJ

mortality/aging

premature death ( J:76202 )

• some mice die after 50 weeks while others survive beyond 70 weeks

neoplasm

increased tumor incidence ( J:76202 )

• tumor cells proliferate continuously in the polyps

increased hepatocellular carcinoma incidence ( J:76202 )

• after 30 weeks in most mice

increased hamartoma incidence ( J:76202 , J:107275 )

• polyps exhibit characteristics of hamartomas (J:76202)

• after 20 weeks, mice develop gastric hamartomas unlike wild-type mice (J:107275)

• hamartomas are composed of glandular and cystic epithelial layers without dysplastic signs (J:107275)

digestive/alimentary system

gastric polyps ( J:76202 )

• after 20 weeks, 93% of mice develop gastric polyps unlike wild-type mice

• after 40 weeks, all mice develop gastric polyps unlike in wild-type mice

• polyps develop in the glandular stomach and small intestine of older mice

• after 50 weeks, 31% of mice develop small intestinal polyps unlike wild-type mice

• small polyps are sessile while larger ones are pedunculated and consist of glandular and cystic epithelial layers

liver/biliary system

increased hepatocellular carcinoma incidence ( J:76202 )

• after 30 weeks in most mice

Genotype
MGI:3851991

cx3

• Allelic Composition: Stk11^tm1Mmt/Stk11⁺; Trp53^tm1Brd/Trp53^tm1Brd
• Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

mortality/aging

premature death ( J:107275 )

• mice by at 7 months

neoplasm

increased tumor incidence ( J:107275 )

• at 25 weeks, one mouse develops bladder tumor unlike wild-type mice

increased ovary tumor incidence ( J:107275 )

♀ • in two mice at 30 weeks

increased liver tumor incidence ( J:107275 )

• 12 mice develop hepatic nodular foci unlike in wild-type mice

increased hepatocellular carcinoma incidence ( J:107275 )

• between 25 and 30 weeks in one mouse

increased hamartoma incidence ( J:107275 )

• after 12 weeks, all mice develop gastric hamartomas unlike wild-type mice

liver/biliary system

abnormal hepatocyte morphology ( J:107275 )

• enlarged and dysplastic in nodules

increased liver tumor incidence ( J:107275 )

• 12 mice develop hepatic nodular foci unlike in wild-type mice

increased hepatocellular carcinoma incidence ( J:107275 )

• between 25 and 30 weeks in one mouse

reproductive system

increased ovary tumor incidence ( J:107275 )

♀ • in two mice at 30 weeks

endocrine/exocrine glands

increased ovary tumor incidence ( J:107275 )

♀ • in two mice at 30 weeks

Genotype
MGI:3851992

cx4

• Allelic Composition: Stk11^tm1Mmt/Stk11⁺; Trp53^tm1Brd/Trp53⁺
• Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

neoplasm

increased hamartoma incidence ( J:107275 )

• after 20 weeks, mice develop gastric hamartomas unlike wild-type mice

• at 24 weeks, all mice develop gastric hamartomas unlike wild-type mice

• hamartomas are composed of glandular and cystic epithelial layers without dysplastic signs