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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sh2b3tm1Rmp
targeted mutation 1, Roger M Perlmutter
MGI:2180088
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sh2b3tm1Rmp/Sh2b3tm1Rmp involves: 129S4/SvJae MGI:3774673


Genotype
MGI:3774673
hm1
Allelic
Composition		 Sh2b3tm1Rmp/Sh2b3tm1Rmp
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2b3tm1Rmp mutation (1 available); any Sh2b3 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal hematopoietic stem cell morphology ( J:131265 )
• unlike wild-type hematopoietic stem cells, migration of Lin- c-kit+ Sca-1+ cells in the presence of non-Lin- cells is impaired
• migration of precursor cells through a VCAM-1-coated membrane is impaired compared to wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory