All Phenotypes Nr5a1<tm2.1Klp> MGI Mouse

prostate gland hypoplasia ( J:66593 )

• treatment with exogenous gonadotropins stimulated enlargement of the hypoplastic prostate glands

seminal vesicle hypoplasia ( J:66593 )

• treatment with exogenous gonadotropins stimulated enlargement of the hypoplastic seminal vesicles

absent corpus luteum ( J:66593 )

absent mature ovarian follicles ( J:66593 )

• although ovarian follicles develop through the primary, secondary and antral stages, no large preovulatory follicles or corpora lutea are observed

• treatment with exogenous gonadotropins (PMSG) stimulated maturation of ovarian follicles to the preovulatory stage and induced ovulation, as indicated by the presence of corpora lutea

ovary hypoplasia ( J:66593 )

• severe

abnormal Leydig cell morphology ( J:66593 )

• mutant Leydig cells display none of the histological features typical of steroidogenic cells

decreased Leydig cell number ( J:66593 )

• interstitial Leydig cells are severely reduced in number

• treatment with exogenous gonadotropins stimulated Leydig cell hypertrophy and induced luminal opening of the seminiferous tubules

testis hypoplasia ( J:66593 )

• severe

cryptorchism ( J:66593 )

• mutant males have cryptorchid testes

decreased male germ cell number ( J:66593 )

• male germ cells are significantly reduced in number

abnormal female reproductive system morphology ( J:66593 )

absent corpus luteum ( J:66593 )

absent mature ovarian follicles ( J:66593 )

• although ovarian follicles develop through the primary, secondary and antral stages, no large preovulatory follicles or corpora lutea are observed

• treatment with exogenous gonadotropins (PMSG) stimulated maturation of ovarian follicles to the preovulatory stage and induced ovulation, as indicated by the presence of corpora lutea

uterus hypoplasia ( J:66593 )

• treatment with exogenous gonadotropins (PMSG) stimulated a significant increase in uterine size and development of the endometrial glands

abnormal spermatogenesis ( J:66593 )

• mutant males fail to progress through the normal stages of spermatogenesis: occasional pachytene spermatocytes are observed, but mature spermatids are absent

• treatment with exogenous gonadotropins (PMSG) stimulated gonadal steroidogenesis, inducing maturation of spermatogonial precursors to the round spermatid stage

abnormal spermatid morphology ( J:66593 )

• no mature spermatids are observed

abnormal male reproductive system morphology ( J:66593 )

• mutant males show hypoplastic external and internal genitalia

prostate gland hypoplasia ( J:66593 )

• treatment with exogenous gonadotropins stimulated enlargement of the hypoplastic prostate glands

seminal vesicle hypoplasia ( J:66593 )

• treatment with exogenous gonadotropins stimulated enlargement of the hypoplastic seminal vesicles

abnormal Leydig cell morphology ( J:66593 )

• mutant Leydig cells display none of the histological features typical of steroidogenic cells

decreased Leydig cell number ( J:66593 )

• interstitial Leydig cells are severely reduced in number

• treatment with exogenous gonadotropins stimulated Leydig cell hypertrophy and induced luminal opening of the seminiferous tubules

cryptorchism ( J:66593 )

• mutant males have cryptorchid testes

external male genitalia hypoplasia ( J:66593 )

internal male genitalia hypoplasia ( J:66593 )

small gonad ( J:66593 )

• mutant gonads are severely hypoplastic

ovary hypoplasia ( J:66593 )

• severe

testis hypoplasia ( J:66593 )

• severe

delayed vaginal opening ( J:66593 )

• mutant vaginas fail to open at the normal age of puberty

absent sexual maturation ( J:66593 )

• both male and female mutants are viable but fail to show signs of secondary sexual maturation, even at 6 months of age

• both male and female mutants exhibit sexual infantilism of the accessory sex organs

anovulation ( J:66593 )

female infertility ( J:66593 )

male infertility ( J:66593 )

decreased follicle stimulating hormone level ( J:66593 )

• although mutant pituitaries appear histologically intact, immunoreactive FSH leves are virtually undetectable

• in contrast, pituitary ACTH, TSH and prolactin levels are comparable to those in wild-type pituitaries

decreased circulating follicle stimulating hormone level ( J:66593 )

• serum FSH levels are significantly reduced in both male and female mutants relative to wild-type controls

decreased luteinizing hormone level ( J:66593 )

• although mutant pituitaries appear histologically intact, immunoreactive LH leves are virtually undetectable

decreased circulating luteinizing hormone level ( J:66593 )

• serum LH levels are significantly reduced in male mutants relative to wild-type controls

abnormal spermatid morphology ( J:66593 )

• no mature spermatids are observed

decreased male germ cell number ( J:66593 )

• male germ cells are significantly reduced in number

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hypogonadotropic hypogonadism		DOID:0090070	OMIM:PS147950	J:66593

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24