mortality/aging
• 60% loss of pups after birth until 4 weeks postnatal, no loss thereafter
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behavior/neurological
• under constant darkness
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• longer phase delay in locomotor activity after light pulse in early evening vs. wild-type
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growth/size/body
• adult females had weak, but significant decreased body weight vs. wild-type littermates
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homeostasis/metabolism
• in glucose tolerance tests
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• mild, in fed state
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• decreased glucose clearance in glucose tolerance tests
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immune system
• increased mortality in LPS-induced endotoxemia
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reproductive system
• a longer and irregular diestrus was observed
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• the oestrus cycle lasted more than 4 days
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• pairings produced one-third the number of litters produced by wildtype matings
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