About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adcyap1r1tm1Bbt
targeted mutation 1, Philippe Brabet
MGI:2180097
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Adcyap1r1tm1Bbt/Adcyap1r1tm1Bbt involves: 129 * C57BL/6J MGI:2447790
ht2
 		Adcyap1r1tm1Bbt/Adcyap1r1+ involves: 129 * C57BL/6J MGI:3615332


Genotype
MGI:2447790
hm1
Allelic
Composition		 Adcyap1r1tm1Bbt/Adcyap1r1tm1Bbt
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcyap1r1tm1Bbt mutation (0 available); any Adcyap1r1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:62115 )
• 60% loss of pups after birth until 4 weeks postnatal, no loss thereafter

behavior/neurological
shortened circadian behavior period ( J:70076 )
• under constant darkness
delayed circadian behavior phase ( J:70076 )
• longer phase delay in locomotor activity after light pulse in early evening vs. wild-type

growth/size/body
decreased body weight ( J:62115 )
• adult females had weak, but significant decreased body weight vs. wild-type littermates

homeostasis/metabolism
decreased circulating insulin level ( J:62115 )
• in glucose tolerance tests
increased circulating insulin level ( J:62115 )
• mild, in fed state
impaired glucose tolerance ( J:62115 )
• decreased glucose clearance in glucose tolerance tests

immune system
increased susceptibility to bacterial infection ( J:73990 )
• increased mortality in LPS-induced endotoxemia

reproductive system
prolonged diestrus ( J:105125 )
• a longer and irregular diestrus was observed
prolonged estrous cycle ( J:105125 )
• the oestrus cycle lasted more than 4 days
reduced female fertility ( J:105125 )
• pairings produced one-third the number of litters produced by wildtype matings




Genotype
MGI:3615332
ht2
Allelic
Composition		 Adcyap1r1tm1Bbt/Adcyap1r1+
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcyap1r1tm1Bbt mutation (0 available); any Adcyap1r1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reduced female fertility ( J:105125 )
• paired heterozygous matings produced half the number of litters as did wildtype maitngs




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory