Phenotypes associated with this allele

• Allele Symbol: Adh1^tm1Gdu
• Allele Name: targeted mutation 1, Gregg Duester
• Allele ID: MGI:2180100
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adh1^tm1Gdu/Adh1^tm1Gdu	B6.129-Adh1^tm1Gdu	MGI:7532769
hm2	Adh1^tm1Gdu/Adh1^tm1Gdu	involves: 129S1/Sv * 129X1/SvJ * Black Swiss	MGI:2447865

Genotype
MGI:7532769

hm1

• Allelic Composition: Adh1^tm1Gdu/Adh1^tm1Gdu
• Genetic Background: B6.129-Adh1^tm1Gdu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal ethanol metabolism ( J:339440 )

• after an acute ethanol (EtOH) binge (single dose of 5 g/kg), mice exhibit significantly higher serum EtOH levels than wild-type controls at all time points analyzed post-gavage

Genotype
MGI:2447865

hm2

• Allelic Composition: Adh1^tm1Gdu/Adh1^tm1Gdu
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

homeostasis/metabolism

abnormal ethanol metabolism ( J:55555 )

• severely defective ethanol clearance

• increase in ethanol-induced embryo resorption during pregnancy compared to controls

abnormal retinol metabolism ( J:55555 , J:76746 , J:85538 )

• reduced metabolism of retinol to retinoic acid (J:55555)

• acute retinol toxicity (J:76746)

• defective retinol clearance, indicated by elevated serum retinol levels (J:76746)

• reduced retinol metabolism to retinoic acid (J:85538)

behavior/neurological

enhanced behavioral response to alcohol ( J:55555 )

• significant increase in the length of ethanol-induced sleep