All Phenotypes Adh7<tm1Gdu> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adh7^tm1Gdu/Adh7^tm1Gdu	B6.129(Cg)-Adh7^tm1Gdu	MGI:4936868
hm2	Adh7^tm1Gdu/Adh7^tm1Gdu	involves: 129S1/Sv * 129X1/SvJ * Black Swiss	MGI:2447868
ht3	Adh7^tm1Gdu/Adh7⁺	B6.129(Cg)-Adh7^tm1Gdu	MGI:4936869
cx4	Adh1^tm2Gdu/Adh1^tm2Gdu Adh7^tm1Gdu/Adh7^tm1Gdu	involves: 129S1/Sv * 129X1/SvJ * Black Swiss	MGI:3845829

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:167234 )

N	• mutants exhibit normal spontaneous rearing, motility and locomotion

enhanced behavioral response to xenobiotic ( J:167234 )

• administration of D-amphetamine significantly increases the motility and locomotion of 12-17 month old male mutants compared to wild-type mice

• administration of apomorphine results in a higher response in horizontal movement in 12-17 month old mutants than in wild-type mice

abnormal locomotor behavior ( J:167234 )

• administration of D-amphetamine significantly increases the motility and locomotion of 12-17 month old male mutants compared to wild-type mice

• administration of apomorphine results in a higher response in horizontal movement in 12-17 month old mutants than in wild-type mice

growth/size/body

decreased body weight ( J:167234 )

• males exhibit a lower weight than controls at 12-17 months of age

nervous system

abnormal substantia nigra morphology ( J:167234 )

• levels of dopamine and dopamine dihydroxyphenylacetic acid (DOPAC), a monoamine metabolite, are increased in the substantia nigra

abnormal olfactory bulb morphology ( J:167234 )

• significantly increased levels of the monoamine metabolite, DOPAC are observed in the olfactory bulb, however levels of dopamine are normal

taste/olfaction

impaired olfaction ( J:167234 )

• 18-20 month old mutants exhibit impaired olfaction, with mice showing longer times to find an odor target than wild-type mice

homeostasis/metabolism

increased dopamine level ( J:167234 )

• levels of dopamine and dopamine dihydroxyphenylacetic acid (DOPAC), a monoamine metabolite, are increased in the substantia nigra

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease		DOID:14330	OMIM:PS168600	J:167234

Allelic Composition	Adh7^tm1Gdu/Adh7^tm1Gdu
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adh7^tm1Gdu mutation (1 available); any Adh7 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:76055 )

• retinol toxicity is increased in these mice with a LD50 that is 1.6-fold less than controls

homeostasis/metabolism

abnormal vitamin A level ( J:55555 )

• retinol-treated mutants have significantly lower levels of kidney retinoic acid than wild-type

abnormal ethanol metabolism ( J:55555 , J:56168 )

• increase in ethanol-induced embryo resorption during pregnancy compared to controls (J:55555)

• defective ethanol clearance (J:56168)

abnormal retinol metabolism ( J:56168 , J:76055 )

• reduced metabolism of retinal to retinoic acid (J:56168)

• retinol toxicity is increased in these mice with a LD50 that is 1.6-fold less than controls (J:76055)

Allelic Composition	Adh7^tm1Gdu/Adh7⁺
Genetic Background	B6.129(Cg)-Adh7^tm1Gdu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adh7^tm1Gdu mutation (1 available); any Adh7 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

enhanced behavioral response to xenobiotic ( J:167234 )

• administration of D-amphetamine significantly increases the motility of mutants compared to wild-type

abnormal locomotor behavior ( J:167234 )

• administration of D-amphetamine significantly increases the motility of mutants compared to wild-type

decreased vertical activity ( J:167234 )

• heterozygotes exhibit a decrease in spontaneous rearing, but no differences in motility or locomotion

Allelic Composition	Adh1^tm2Gdu/Adh1^tm2Gdu Adh7^tm1Gdu/Adh7^tm1Gdu
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adh1^tm2Gdu mutation (0 available); any Adh1 mutation (32 available)
Adh7^tm1Gdu mutation (1 available); any Adh7 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:76055 )

• mice exposed to vitamin A deficiency in utero start dying during the postnatal period with all mice dead by 25 days of age

homeostasis/metabolism

abnormal retinol metabolism ( J:76055 )

• following administration of a 50-mg/kg dose of retinol, there is a 10-fold decrease in retinoic acid production in the liver and a 23-fold drop in the sera compared to wild-type mice

• retinol toxicity is increased in these mice with a LD50 that is 2.2-fold less than controls

growth/size/body

weight loss ( J:76055 )

• mice exposed to vitamin A deficiency in utero have bodyweight that deviate downward from WT at 8 days of age

• body weights beyond 6 g were not achieved before death

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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