Phenotypes associated with this allele

• Allele Symbol: Asic2^tm1Wsh
• Allele Name: targeted mutation 1, Michael J Welsh
• Allele ID: MGI:2180111
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Asic2^tm1Wsh/Asic2^tm1Wsh	involves: 129S1/Sv * 129X1/SvJ	MGI:4354578
ht2	Asic2^tm1Wsh/Asic2^+	involves: 129S1/Sv * 129X1/SvJ	MGI:4354592

Genotype
MGI:4354578

hm1

• Allelic Composition: Asic2^tm1Wsh/Asic2^tm1Wsh
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal nervous system electrophysiology ( J:76712 )

• low threshold, rapid adapting mechanoreceptors exhibit reduced sensitivity compared with wild-type mechanoreceptors

• low threshold, rapid adapting mechanoreceptor stimulus response function exhibits reduced discharge frequency and flattens unlike in wild-type mechanoreceptors

• low threshold, rapid adapting mechanoreceptors exhibit reduced sensitivity between 5 and 20 um displacement unlike wild-type mechanoreceptor

• the stimulus-response of slowly adapting mechanoreceptor exhibits decreased sensitivity compared to wild-type mechanoreceptors

• however, sensory neurons exhibit normal response to current injection

hearing/vestibular/ear

abnormal hearing electrophysiology ( J:96521 )

• pH changes fail to generate firing of action potentials in spiral ganglion unlike similarly treated wild-type cells

• proton-induced current flows in spiral ganglion compared with wild-type cells

• following exposure to 110 dB white-band noise, mice exhibit a decrease in their susceptibilities to noise-induced temporary threshold shifts compared with wild-type mice

• however, auditory brainstem response is normal

cardiovascular system

decreased vasoconstriction ( J:135644 )

• mice exhibit decreased pressure-induced constriction of the middle cerebral artery in the presence of calcium unlike similarly treated wild-type mice

• mice develop myogenic tone with increases in intraluminal pressure but generate less tone at every pressure step compared with similarly treated wild-type mice

behavior/neurological

behavior/neurological phenotype ( J:119060 )

N • hyperalgesia induced by repeated acid injections is normal

taste/olfaction

taste/olfaction phenotype ( J:96875 )

N • mice exhibit normal physiological responses to acid taste stimuli

muscle

decreased vasoconstriction ( J:135644 )

• mice exhibit decreased pressure-induced constriction of the middle cerebral artery in the presence of calcium unlike similarly treated wild-type mice

• mice develop myogenic tone with increases in intraluminal pressure but generate less tone at every pressure step compared with similarly treated wild-type mice

Genotype
MGI:4354592

ht2

• Allelic Composition: Asic2^tm1Wsh/Asic2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

cardiovascular system

abnormal blood vessel physiology ( J:135644 )

• wall tension under calcium ion containing conditions in cerebral arteries is increased compared to in wild-type mice

• however, mechanical properties of blood vessels (strain, stress, stress-strain relationship, incremental distensibility, inner diameter, outer diameter, wall thickness, and wall thickness-to-lumen ratio)

decreased vasoconstriction ( J:135644 )

• mice fail to exhibit pressure-induced constriction in the middle cerebral artery in the presence of calcium unlike similarly treated wild-type mice

• mice fail to generate myogenic tone in response to intraluminal pressure unlike similarly treated wild-type mice

muscle

decreased vasoconstriction ( J:135644 )

• mice fail to exhibit pressure-induced constriction in the middle cerebral artery in the presence of calcium unlike similarly treated wild-type mice

• mice fail to generate myogenic tone in response to intraluminal pressure unlike similarly treated wild-type mice