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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Aebp1tm1Mdl
targeted mutation 1, Matthew D Layne
MGI:2180115
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Aebp1tm1Mdl/Aebp1tm1Mdl involves: 129S2/SvPas * C57BL/6 MGI:2654820


Genotype
MGI:2654820
hm1
Allelic
Composition
Aebp1tm1Mdl/Aebp1tm1Mdl
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aebp1tm1Mdl mutation (0 available); any Aebp1 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only 6.6% of homozygous mutants survive to weaning /adulthood
• most mutants die around birth from gastroschisis, but 6.6% of homozygous mutants survive to weaning

growth/size/body
• extrusion of intestines, and often the liver, into amniotic cavity
• detected as early as E13.5

digestive/alimentary system
• intestines are absent in some mutants

limbs/digits/tail
• frequently have a bent or looped tail
• frequently have a bent or looped tail

liver/biliary system
• liver is absent in some mutants

homeostasis/metabolism
• mutants show a reduction in the rate or extent of healing after a 3-mm dermal punch biopsy

cellular
• isolated dermal fibroblasts from E18.5 embryo skin exhibit a lower proliferation rate than controls

integument
• the few mutants that survive to adulthood exhibit skin lesions





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory