mortality/aging
• only 6.6% of homozygous mutants survive to weaning /adulthood
|
• most mutants die around birth from gastroschisis, but 6.6% of homozygous mutants survive to weaning
|
growth/size/body
• extrusion of intestines, and often the liver, into amniotic cavity
• detected as early as E13.5
|
digestive/alimentary system
• intestines are absent in some mutants
|
limbs/digits/tail
curly tail
(
J:70416
)
• frequently have a bent or looped tail
|
kinked tail
(
J:70416
)
• frequently have a bent or looped tail
|
liver/biliary system
• liver is absent in some mutants
|
homeostasis/metabolism
• mutants show a reduction in the rate or extent of healing after a 3-mm dermal punch biopsy
|
cellular
• isolated dermal fibroblasts from E18.5 embryo skin exhibit a lower proliferation rate than controls
|
integument
skin lesions
(
J:70416
)
• the few mutants that survive to adulthood exhibit skin lesions
|