All Phenotypes Pzp<tm1Vln> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pzp^tm1Vln/Pzp^tm1Vln	B.129P2-Pzp^tm1Vln	MGI:3701962
hm2	Pzp^tm1Vln/Pzp^tm1Vln	B6.129P2-Pzp^tm1Vln	MGI:3768640
hm3	Pzp^tm1Vln/Pzp^tm1Vln	involves: 129P2/OlaHsd * C57BL	MGI:2661449
ht4	Pzp^tm1Vln/Pzp⁺	involves: 129P2/OlaHsd * C57BL	MGI:2661448
cx5	Mug1^tm2Vln/Mug1^tm2Vln Pzp^tm1Vln/Pzp^tm1Vln	B.129P2-Pzp^tm1Vln Mug1^tm2Vln	MGI:3701960
cx6	Mug1^tm2Vln/Mug1^tm2Vln Pzp^tm1Vln/Pzp^tm1Vln	involves: 129P2/OlaHsd * C57BL	MGI:3701989

Allelic Composition	Pzp^tm1Vln/Pzp^tm1Vln
Genetic Background	B.129P2-Pzp^tm1Vln

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pzp^tm1Vln mutation (1 available); any Pzp mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:57485 )

• on a choline and methionine-deficient powder diet supplemented with ethionine (CDE), designed to induce acute hemorrhagic pancreatitis, mortality is about 70% after 5 days on the diet compared to 27% in B6 controls

immune system

abnormal cytokine level ( J:57485 )

• after 3 days of CDE diet, some cytokines are upregulated in pancreas of some affected mice

liver inflammation ( J:57485 )

• inflammatory cell infiltrate is observed after 2-3 days of CDE diet

• liver abnormalities are reversed by 4 days of normal diet

endocrine/exocrine glands

abnormal pancreatic acinus morphology ( J:57485 )

• after 5 days, massive necrosis of pancreatic acini is seen, similar to treated wild-type

• in severely affected pancreata after 5 days of CDE diet, acini with enlarged lumen are observed at greater frequency than in wild-type

abnormal pancreatic acinar cell morphology ( J:57485 )

• after 3 days on the CDE diet, pronounced vacuolarization of acinar cells is observed, but not in controls or other mutant lines

liver/biliary system

liver inflammation ( J:57485 )

• inflammatory cell infiltrate is observed after 2-3 days of CDE diet

• liver abnormalities are reversed by 4 days of normal diet

hepatic necrosis ( J:57485 )

• observed after 2-3 days of CDE diet, along with large vacuole formation and remains unchanged afterwards

• liver abnormalities are reversed by 4 days of normal diet

homeostasis/metabolism

increased circulating amylase level ( J:57485 )

• after 66 hours of CDE diet, amylase aplasma concentrations are 4 fold higher compared to wild type; amylase concentrations are significantly higher than in double mutants

• highest amylase levels are observed after 4 days of CDE diet

increased circulating lipase level ( J:57485 )

• after 66 hours of CDE diet, lipase plasma concentrations are 10 fold higher compared to wild type

abnormal cytokine level ( J:57485 )

• after 3 days of CDE diet, some cytokines are upregulated in pancreas of some affected mice

abnormal enzyme/coenzyme activity ( J:57485 )

digestive/alimentary system

abnormal pancreatic acinus morphology ( J:57485 )

• after 5 days, massive necrosis of pancreatic acini is seen, similar to treated wild-type

• in severely affected pancreata after 5 days of CDE diet, acini with enlarged lumen are observed at greater frequency than in wild-type

abnormal pancreatic acinar cell morphology ( J:57485 )

• after 3 days on the CDE diet, pronounced vacuolarization of acinar cells is observed, but not in controls or other mutant lines

Allelic Composition	Pzp^tm1Vln/Pzp^tm1Vln
Genetic Background	B6.129P2-Pzp^tm1Vln

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pzp^tm1Vln mutation (1 available); any Pzp mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal cytokine secretion ( J:113532 )

• 90 minutes after LPS injection, increased tumor necrosis factor alpha (Tnfa) levels in plasma are significantly lower in mutants than in wild-type controls; after 4 hours, Tnfa concentrations in the plasma decrease to pre-injection control levels in mutants and wild-type

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:113532 )

N	• LPS induces significant decrease in body weight and food intake in mutant and wild-type mice during the 24-hour post-injection period, and completely suppressed locomotor activity • injection of turpentine had similar fever-inducing effects and tissue injury in wild-type and mutant mice

impaired febrile response ( J:113532 )

• injection of LPS causes a short-lasting (3 hours) and attenuated febrile (~0.6 degree Celsius) response in mutants compared to wild-type controls (~0.9 degree Celsius increase, lasting up to 7 hours); body temperature increases in controls are significantly higher in response to LPS or saline compared to mutants

Allelic Composition	Pzp^tm1Vln/Pzp^tm1Vln
Genetic Background	involves: 129P2/OlaHsd * C57BL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pzp^tm1Vln mutation (1 available); any Pzp mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:28328 )

• intraperitoneal injection of a dose equal to the LD50 of endotoxin resulted in death of 8/10 wild-type controls within 1 day, but only killed 1/10 mutants; at doses 5 times the LD₅₀ of endotoxin, all control mice died compared to 8/10 mutants

growth/size/body

decreased susceptibility to weight gain ( J:28328 )

• some (7/28 female and 3/18 male) mutants lose weight and become ill when fed a high fat diet for 9 weeks, while all controls gain weight

enlarged liver ( J:28328 )

• livers of some mice that became ill on a high fat diet were significantly enlarged; mice that appear healthy have similar liver phenotype

liver/biliary system

liver/biliary system phenotype ( J:28328 )

N	• intraperitoneal injection of carbon tetrachloride causes centrolobar liver cell necrosis in mutant and wild-type mice

enlarged liver ( J:28328 )

• livers of some mice that became ill on a high fat diet were significantly enlarged; mice that appear healthy have similar liver phenotype

gallstones ( J:28328 )

• gallbladders of some mice that became ill on a high fat diet contain many stones

hepatic steatosis ( J:28328 )

• livers of some mice that became ill on a high fat diet were significantly enlarged; mice that appear healthy have similar liver phenotype

abnormal bile color ( J:28328 )

• bile fluid of mice that became ill on high fat diet is green and turbid instead of clear and yellow in controls

endocrine/exocrine glands

pancreas inflammation ( J:28328 )

• surviving mutant shows pancreatitis characterized by increased connective tissue, serous acini with an enlarged lumen and less cuboidal cells, on the CDE diet; controls surviving the deficient diet do not show morphological changes in the pancreas

increased susceptibility to induced pancreatitis ( J:28328 )

• when give a choline and methionine-deficient, supplemented with ethionine (CDE) diet, most (5/6) mutants die in 5 days while no control mice die until day 6 of the diet; only 1 mutant survived to day 8 compared to 4/6 controls

behavior/neurological

decreased locomotor activity ( J:28328 )

• some (10/46) mutants show decreased movement and exploration when given a high fat diet for 9 weeks

immune system

pancreas inflammation ( J:28328 )

increased susceptibility to induced pancreatitis ( J:28328 )

neoplasm

neoplasm ( J:28328 )

• when E14 embryonic stem (ES) cells are injected subcutaneously into mutants, mice develop teratomas or teratocarcinomas at site of injections by 3 weeks; no data or control information is provided

• large tumors contain different types of well differentiated cell types, while small tumors have mostly undifferentiated cells and do not appear malignant

respiratory system

respiratory system phenotype ( J:28328 )

N	• after intraperitoneal injection of bleomycin twice a week for 5 weeks, morphology of mutant lungs is not significantly different from placebo injected mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:28328 )

N	• plasma levels of murinoglobulin (MUG) are comparable to wild-type mice, as are levels of MUG in pregnant mutants at parturition

integument

disheveled coat ( J:28328 )

• some mutants (10/46) display disordered and upright fur when given a high fat diet for 9 weeks

greasy coat ( J:28328 )

• some mutants (10/46) develop a greasy coat when given a high fat diet for 9 weeks

Allelic Composition	Pzp^tm1Vln/Pzp⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pzp^tm1Vln mutation (1 available); any Pzp mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:28328 )

• heterozygotes are viable and fertile and display no overt morphological, physiological, or behavioral abnormalities

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:57485 )

• on a choline and methionine-deficient powder diet supplemented with ethionine (CDE) designed to induce acute hemorrhagic pancreatitis, mortality is 60% after 5 days on the diet compared to only 23% in mutants on a mixed background or 70% in Pzp-single null mice

prenatal lethality, incomplete penetrance ( J:117841 )

• resorption sites are observed around midgestation indicating reduced viability

embryo

abnormal placenta vasculature ( J:117841 )

• intravascular uterine NK cells are observed in placental arteries

abnormal maternal decidual layer morphology ( J:117841 )

• intracellular spaces between decidual cells is increased at gd 10

abnormal uterine NK cell morphology ( J:117841 )

• at gd 10, frequency of uterine natural killer (uNK) cells per unit area of decidua basalis is significantly less than in wild-type

• some cells show early degenerative changes, including nuclear chromatin margination and mitochondrial swelling at gd10 and 11, whereas in wild-type, such changes aren't seen until after gd 12

abnormal uterine spiral artery morphology ( J:117841 )

• at gd 10-12, decidual spiral arteries are widely dilated but abnormally cuffed by large trophoblast cells which are embedded in spiral artery walls and surround the entire vessel circumference; this is not observed in wild-type

• these perivascular and intramural trophoblast cells extend to the myometrial circular smooth muscle but do not cross it on gd 10-12; this depth of invasion does not occur until ~gd 18 in wild-type

abnormal placenta labyrinth morphology ( J:117841 )

• cytoplasm of trophoblast cells contain more phagolysosomes and lamellar bodies than wild-type

abnormal trophoblast layer morphology ( J:117841 )

• deciduas/trophoblast interface is abnormal with typical dome of trophoblast giant cells extensively disrupted by compact tissue made of large eosinophilic cells extending into decidua basalis almost reaching circular smooth muscle

abnormal decidualization ( J:117841 )

• decidual cells contain smaller nuclei and cells are hypotrophic than wild-type cells at gestational day (gd) 10

growth/size/body

decreased body weight ( J:117841 )

• pups are smaller than wild-type pups

• at 4, 6, and 8 weeks, female mean weights are 11.2, 14.9, and 17.5 g compared to 14.3, 18.4, and 19 g for wild-type females; male mean weights 12.7, 18.5, and 22.5 g vs 17.1, 22.8, and 25.2 g for wild-type analyzed at same time points as females

reproductive system

abnormal maternal decidual layer morphology ( J:117841 )

• intracellular spaces between decidual cells is increased at gd 10

abnormal uterine NK cell morphology ( J:117841 )

• at gd 10, frequency of uterine natural killer (uNK) cells per unit area of decidua basalis is significantly less than in wild-type

• some cells show early degenerative changes, including nuclear chromatin margination and mitochondrial swelling at gd10 and 11, whereas in wild-type, such changes aren't seen until after gd 12

abnormal uterine spiral artery morphology ( J:117841 )

abnormal uterine environment ( J:117841 )

• at gd 10, frequency of uterine natural killer cells per unit area of decidua basalis is significantly less than in wild-type

abnormal decidualization ( J:117841 )

• decidual cells contain smaller nuclei and cells are hypotrophic than wild-type cells at gestational day (gd) 10

decreased litter size ( J:117841 )

• homozygous matings yield slightly smaller litters (4.9 pups/litter) vs control data for wild-type (6.1-7.6 pups/litter)

hematopoietic system

abnormal uterine NK cell morphology ( J:117841 )

• at gd 10, frequency of uterine natural killer (uNK) cells per unit area of decidua basalis is significantly less than in wild-type

• some cells show early degenerative changes, including nuclear chromatin margination and mitochondrial swelling at gd10 and 11, whereas in wild-type, such changes aren't seen until after gd 12

immune system

abnormal uterine NK cell morphology ( J:117841 )

• at gd 10, frequency of uterine natural killer (uNK) cells per unit area of decidua basalis is significantly less than in wild-type

• some cells show early degenerative changes, including nuclear chromatin margination and mitochondrial swelling at gd10 and 11, whereas in wild-type, such changes aren't seen until after gd 12

abnormal cytokine level ( J:57485 )

• after 3 days of CDE diet, some cytokines are upregulated in pancreas of some affected mice

liver inflammation ( J:57485 )

• inflammatory cell infiltrate is observed after 2-3 days of CDE diet

• liver abnormalities are reversed by 4 days of normal diet

liver/biliary system

liver inflammation ( J:57485 )

• inflammatory cell infiltrate is observed after 2-3 days of CDE diet

• liver abnormalities are reversed by 4 days of normal diet

hepatic necrosis ( J:57485 )

• observed after 2-3 days of CDE diet, along with large vacuole formation and remains unchanged afterwards

homeostasis/metabolism

increased circulating amylase level ( J:57485 )

• after 66 hours of CDE diet, amylase plasma concentrations are significantly higher than in wild-type

increased circulating lipase level ( J:57485 )

• after 66 hours of CDE diet, lipase plasma concentrations are significantly higher than in wild-type

abnormal cytokine level ( J:57485 )

• after 3 days of CDE diet, some cytokines are upregulated in pancreas of some affected mice

cardiovascular system

abnormal placenta vasculature ( J:117841 )

• intravascular uterine NK cells are observed in placental arteries

endocrine/exocrine glands

abnormal uterine NK cell morphology ( J:117841 )

• at gd 10, frequency of uterine natural killer (uNK) cells per unit area of decidua basalis is significantly less than in wild-type

• some cells show early degenerative changes, including nuclear chromatin margination and mitochondrial swelling at gd10 and 11, whereas in wild-type, such changes aren't seen until after gd 12

Allelic Composition	Mug1^tm2Vln/Mug1^tm2Vln Pzp^tm1Vln/Pzp^tm1Vln
Genetic Background	involves: 129P2/OlaHsd * C57BL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mug1^tm2Vln mutation (1 available); any Mug1 mutation (115 available)
Pzp^tm1Vln mutation (1 available); any Pzp mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

abnormal induced morbidity/mortality ( J:57485 )

• Background Sensitivity: on a choline and methionine-deficient powder diet supplemented with ethionine (CDE), designed to induce acute hemorrhagic pancreatitis, mortality is 23% after 5 days on the diet compared to 60% in mutants on a congenic B6 background

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