Phenotypes associated with this allele

• Allele Symbol: Adcyap1r1^tm1.1Gsc
• Allele Name: targeted mutation 1.1, Gunther Schutz
• Allele ID: MGI:2180119
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adcyap1r1^tm1.1Gsc/Adcyap1r1^tm1.1Gsc	involves: 129P2/OlaHsd	MGI:2447753

Genotype
MGI:2447753

hm1

• Allelic Composition: Adcyap1r1^tm1.1Gsc/Adcyap1r1^tm1.1Gsc
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:76715 )

• incomplete penetrance; reduced numbers of homozygous mutants at weaning (19%, rather than 25%)

behavior/neurological

abnormal contextual conditioning behavior ( J:76715 )

• reduced freezing response in long term test of contextual fear conditioning

decreased anxiety-related response ( J:71399 )

• less anxious, assessed by open field, zero-maze, elevated plus maze and dark-light box tests

increased vertical activity ( J:76715 )

• increased locomotor activity in both horizontal and vertical planes

increased locomotor activity ( J:71399 )

• increased locomotor activity in both horizontal and vertical planes

nervous system

reduced long-term potentiation ( J:76715 )

• no LTP in mossy fibers