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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ahsgtm1Mbl
targeted mutation 1, Manfred Blessing
MGI:2180147
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ahsgtm1Mbl/Ahsgtm1Mbl B6.129-Ahsgtm1Mbl MGI:4415324
hm2
Ahsgtm1Mbl/Ahsgtm1Mbl involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:2654843


Genotype
MGI:4415324
hm1
Allelic
Composition
Ahsgtm1Mbl/Ahsgtm1Mbl
Genetic
Background
B6.129-Ahsgtm1Mbl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ahsgtm1Mbl mutation (0 available); any Ahsg mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• body weight is decreased on a normal chow diet
• on a high fat diet homozygotes gain less weight (body weight increase of 8.44% compared to 15.83 for wild-type mice) despite having similar total caloric intake compared to wild-type mice
• on a high fat diet homozygotes remain lean unlike wild-type mice

homeostasis/metabolism
• on a high fat diet homozygotes remain lean unlike wild-type mice
• on a high fat diet fasting insulin levels are lower in homozygotes compared to wild-type mice on the same diet, no difference is seen on a normal chow diet
• under fasting conditions; however plasma leptin levels are normal
• under fasting conditions
• glucose clearance is increased during oral or i.p. glucose tolerance tests compared to age, sex, and weight matched wild-type mice
• increased insulin sensitivity is seen on both normal and high fat diets
• at lower doses of insulin the drop in blood glucose is increased in homozygotes and during euglycemic clamp assays glucose infusion rates were higher in homozygotes




Genotype
MGI:2654843
hm2
Allelic
Composition
Ahsgtm1Mbl/Ahsgtm1Mbl
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ahsgtm1Mbl mutation (0 available); any Ahsg mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• defective inhibition of apatite formation in serum

muscle
• a small number of female ex-breeders display soft tissue microcalcification





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory