Phenotypes associated with this allele

• Allele Symbol: Syt1^tm3Sud
• Allele Name: targeted mutation 3, Thomas C Sudhof
• Allele ID: MGI:2180148
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Syt1^tm3Sud/Syt1^tm3Sud	involves: 129P2/OlaHsd * C57BL/6	MGI:2181657

Genotype
MGI:2181657

hm1

• Allelic Composition: Syt1^tm3Sud/Syt1^tm3Sud
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased excitatory postsynaptic current amplitude ( J:76452 )

• the ESPC amplitudes of mutant neurons were smaller than controls during repetitive stimulation; facilitation of the response was seen at various frequencies whereas synaptic depression was seen in controls

abnormal neurotransmitter secretion ( J:76452 )

• the fast, synchronous, Ca2+ dependent phase of neurotransmitter release is affected, while the spontaneous release of neurotransmitters is unaffected

• the Ca2+ dependent synaptic release probability was decreased two-fold, but was not due to a decrease in the readily releasable pool of neurotransmitters