All Phenotypes Akt1<tm1Mbb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Akt1^tm1Mbb
targeted mutation 1, Morris J Birnbaum
MGI:2180150

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Akt1^tm1Mbb/Akt1^tm1Mbb	B6.129P2-Akt1^tm1Mbb	MGI:5317894
hm2	Akt1^tm1Mbb/Akt1^tm1Mbb	involves: 129P2/OlaHsd	MGI:3574758
hm3	Akt1^tm1Mbb/Akt1^tm1Mbb	involves: 129P2/OlaHsd * C57BL/6	MGI:2674288
cx4	Akt1^tm1Mbb/Akt1⁺ Flt1^tm1Jrt/Flt1⁺	involves: 129P2/OlaHsd	MGI:4844292

Allelic Composition	Akt1^tm1Mbb/Akt1^tm1Mbb
Genetic Background	B6.129P2-Akt1^tm1Mbb

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt1^tm1Mbb mutation (1 available); any Akt1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:182721 )

• when fed a high fat diet

increased carbon dioxide production ( J:182721 )

• when fed normal chow or a high fat diet

increased oxygen consumption ( J:182721 )

• when fed normal chow or a high fat diet

increased basal metabolism ( J:182721 )

• when fed normal chow or a high fat diet

growth/size/body

decreased lean body mass ( J:182721 )

• when fed normal chow or a high fat diet

decreased body weight ( J:182721 )

• when fed normal chow or a high fat diet

decreased susceptibility to diet-induced obesity ( J:182721 )

• when fed a high fat diet

adipose tissue

decreased percent body fat/body weight ( J:182721 )

• when fed normal chow or a high fat diet

Allelic Composition	Akt1^tm1Mbb/Akt1^tm1Mbb
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt1^tm1Mbb mutation (1 available); any Akt1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased myocardial fiber size ( J:96823 )

• cardiomyocytes were 19% smaller than in wildtype

growth/size/body

decreased body size ( J:96823 )

• reduced body size with smaller liver and heart and a 14% reduction in brain size that was proportional to the reduction in body size

liver/biliary system

decreased hepatocyte number ( J:96823 )

• decreased number of cells in the liver

muscle

decreased myocardial fiber size ( J:96823 )

• cardiomyocytes were 19% smaller than in wildtype

nervous system

abnormal brain morphology ( J:96823 )

• decreased cell number in the brain

Allelic Composition	Akt1^tm1Mbb/Akt1^tm1Mbb
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt1^tm1Mbb mutation (1 available); any Akt1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:72176 )

• normal numbers of homozygous embryos at E13.5

• by 2-3 weeks after birth, fewer than expected numbers of homozygotes seen

• significant numbers of deaths among homozygotes observed with first three days of life

• survivors were fertile

nervous system

decreased prepulse inhibition ( J:185487 )

• in mice treated with amphetamine

• however, mice exhibit normal prepulse inhibition at baseline or following treatment with MK801

growth/size/body

decreased body weight ( J:72176 )

• 20% reduction in body weight at birth

• at 14 months, homozygous males were only about 75% normal weight

behavior/neurological

behavior/neurological phenotype ( J:185487 )

N	• mice exhibit normal startle response

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:185487

Allelic Composition	Akt1^tm1Mbb/Akt1⁺ Flt1^tm1Jrt/Flt1⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt1^tm1Mbb mutation (1 available); any Akt1 mutation (34 available)
Flt1^tm1Jrt mutation (1 available); any Flt1 mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:151369 )

N	• following hind limb ischemia, mice exhibit normal blood flow and capillary density

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