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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stx4atm1Jpes
targeted mutation 1, Jeffrey E Pessin
MGI:2180164
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Stx4atm1Jpes/Stx4atm1Jpes involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:2181807
ht2
 		Stx4atm1Jpes/Stx4a+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:2181810


Genotype
MGI:2181807
hm1
Allelic
Composition		 Stx4atm1Jpes/Stx4atm1Jpes
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stx4atm1Jpes mutation (1 available); any Stx4a mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:2181810
ht2
Allelic
Composition		 Stx4atm1Jpes/Stx4a+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stx4atm1Jpes mutation (1 available); any Stx4a mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating insulin level ( J:69598 )
• measured in fasting serum of heterozygous mice
impaired glucose tolerance ( J:69598 )
• heterozygous mice exhibit a reduced ability to clear glucose from the peripheral circulation
insulin resistance ( J:69598 )
• skeletal muscle of heterozygous mice exhibits an impaired ability to transport glucose; adipose tissue and liver were unaffected




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory