Phenotypes associated with this allele

• Allele Symbol: Stambp^tm1Sug
• Allele Name: targeted mutation 1, Kazuo Sugamura
• Allele ID: MGI:2180168
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stambp^tm1Sug/Stambp^tm1Sug	involves: 129S4/SvJae * C57BL/6	MGI:3029675

Genotype
MGI:3029675

hm1

• Allelic Composition: Stambp^tm1Sug/Stambp^tm1Sug
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality at weaning, complete penetrance ( J:72940 )

• homozygous animals die between P19 and P23; death appears to be due to starvation

behavior/neurological

limb grasping ( J:72940 )

• homozygous animals exhibit a limb-clasping reflex when lifted by the legs; control animals extend the legs

growth/size/body

postnatal growth retardation ( J:72940 )

• apparent by P7 in homozygous mice

immune system

immune system phenotype ( J:72940 )

N • no defects were seen in T and B lymphocyte development or in T cell proliferative responses

vision/eye

blepharoptosis ( J:72940 )

• seen in one third of homozygous mice at P16

nervous system

hippocampal neuron degeneration ( J:72940 )

• neurons of the CA1 region appear degenerated and are apoptotic by P6; the CA1 field was abolished by P16

abnormal cerebral cortex morphology ( J:72940 )

• the cellularity of the cerebral cortex was reduced by P11; the layers appeared undefined by P16