Phenotypes associated with this allele

• Allele Symbol: Ap1g1^tm1Schu
• Allele Name: targeted mutation 1, Peter Schu
• Allele ID: MGI:2180169
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ap1g1^tm1Schu/Ap1g1^tm1Schu	either: (involves: 129P2/OlaHsd * 129X1/SvJ) or (involves: 129P2/OlaHsd * C57BL/6J)	MGI:2655370
ht2	Ap1g1^tm1Schu/Ap1g1^+	either: (involves: 129P2/OlaHsd * 129X1/SvJ) or (involves: 129P2/OlaHsd * C57BL/6J)	MGI:2655373

Genotype
MGI:2655370

hm1

• Allelic Composition: Ap1g1^tm1Schu/Ap1g1^tm1Schu
• Genetic Background: either: (involves: 129P2/OlaHsd * 129X1/SvJ) or (involves: 129P2/OlaHsd * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:53252 )

• homozygous mutant embryos develop until E3.5 but die during the prenidation period (i.e. before E4.5)

Genotype
MGI:2655373

ht2

• Allelic Composition: Ap1g1^tm1Schu/Ap1g1⁺
• Genetic Background: either: (involves: 129P2/OlaHsd * 129X1/SvJ) or (involves: 129P2/OlaHsd * C57BL/6J)

growth/size/body

decreased body size ( J:53252 )

• following a growth arrest of 2-4 days during weaning, heterozygotes resume normal growth but remain 2.5 g lighter than wild-type littermates for at least up to 10 months of age

postnatal growth retardation ( J:53252 )

• Background Sensitivity: heterozygotes of the inbred colony grow slower than outbred (129P2/OlaHsd x C57BL/6J) heterozygotes

slow postnatal weight gain ( J:53252 )

• between P6 and P21, the body weight of male heterozygotes increases by 0.23 g/d compared with 0.40 g/d in wild-type males

• weaning causes a growth arrest for 2 to 4 days; thereafter, heterozygotes grow as fast as wild-type mice although heterozygous females grow slower than males

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:53252 )

• at 5-7 weeks of age, heterozygotes show a 20% reduction in the number of CD4⁺ single-positive T cells in the thymus relative to wild-type mice

• however, the total number of lymphocytes in spleen and thymus is unaffected

• no abnormalities are detected in splenocytes or in the tissue architecture of thymus and spleen

immune system

decreased CD4-positive, alpha-beta T cell number ( J:53252 )

• at 5-7 weeks of age, heterozygotes show a 20% reduction in the number of CD4⁺ single-positive T cells in the thymus relative to wild-type mice

• however, the total number of lymphocytes in spleen and thymus is unaffected

• no abnormalities are detected in splenocytes or in the tissue architecture of thymus and spleen