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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Araftm1Mmc
targeted mutation 1, Martin McMahon
MGI:2180180
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Araftm1Mmc/Araftm1Mmc involves: 129P2/OlaHsd * C57BL/6 MGI:2655448
ot2
 		Araftm1Mmc/Y involves: 129P2/OlaHsd * C57BL/6 MGI:2655472


Genotype
MGI:2655448
hm1
Allelic
Composition		 Araftm1Mmc/Araftm1Mmc
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Araftm1Mmc mutation (0 available); any Araf mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:33951 )
• Background Sensitivity: females on a predominantly C57BL/6 background die between P7 and P21 while females maintained on a more 129P2/OlaHsd background show 50% survival to adulthood

behavior/neurological
abnormal suckling behavior ( J:33951 )
• suck poorly and have less milk in their stomachs than controls
abnormal anxiety-related response ( J:33951 )
• excessive agitation during handling, loss of bladder control
limb grasping ( J:33951 )
• when lifted by tails, mutants draw their limbs in toward their bodies instead of extending their limbs
tremors ( J:33951 )
• a continuous tremor is seen in females on a predominantly C57BL/6 background
abnormal motor coordination/balance ( J:33951 )
• females predominantly on a C57BL/6 background (F2-F4) have difficulty maintaining an upright position
athetotic walking movements ( J:33951 )
• seen in females on the predominantly C57BL/6 background
weakness ( J:33951 )
• animals had wasted appearance
abnormal limb posture ( J:33951 )
• limbs held in an abnormal posture

digestive/alimentary system
megacolon ( J:33951 )
• Background Sensitivity: 100% penetration of distended colon, primarily affecting the cecum and the proximal end of the colon, in females on a predominantly C57BL/6 background but is not observed in females on a more 129P2/OlaHsd background
abnormal rectum morphology ( J:33951 )
• narrow rectum

growth/size/body
decreased body size ( J:33951 )
• smaller by 2-3 days of age
decreased body weight ( J:33951 )
• weigh less at P5

immune system
small thymus ( J:33951 )
• thymus is reduced in size, 10% of the size of wild-type

muscle
abnormal muscle morphology ( J:33951 )
• muscle rigidity

hematopoietic system
small thymus ( J:33951 )
• thymus is reduced in size, 10% of the size of wild-type

endocrine/exocrine glands
small thymus ( J:33951 )
• thymus is reduced in size, 10% of the size of wild-type




Genotype
MGI:2655472
ot2
Allelic
Composition		 Araftm1Mmc/Y
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Araftm1Mmc mutation (0 available); any Araf mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:33951 )
• Background Sensitivity: F2, F3, and F4 generation males obtained by crossing F1, F2 or F3 heterozygous females to C57BL/6 males die between P7 and P21. However 50% of males obtained from F1 or F2 heterozygous females crossed to chimeric males or to 129P2/OlaHsd males survive to adulthood

behavior/neurological
abnormal suckling behavior ( J:33951 )
• suck poorly and have less milk in their stomachs than controls
abnormal anxiety-related response ( J:33951 )
• excessive agitation when handled, loss of bladder control
limb grasping ( J:33951 )
• when lifted by tails, mutants draw their limbs in toward their bodies instead of extending their limbs
tremors ( J:33951 )
• a continuous tremor is seen in F2, F3, and F4 generation males that were obtained by crossing F1, F2 or F3 heterozygous females to C57BL/6 males
abnormal motor coordination/balance ( J:33951 )
• F2, F3, and F4 generation males, obtained by crossing F1, F2 or F3 heterozygous females to C57BL/6 males, have difficulty maintaining an upright position
athetotic walking movements ( J:33951 )
• seen in F2, F3, and F4 generation males obtained by crossing F1, F2 or F3 heterozygous females to C57BL/6 males
abnormal limb posture ( J:33951 )
• limbs are held in an abnormal positions

digestive/alimentary system
megacolon ( J:33951 )
• Background Sensitivity: 100% penetration of distended colon, primarily affecting the cecum and the proximal end of the colon, in F2, F3, and F4 generation males obtained from crosses of F1, F2, or F3 heterozygous females with C57BL/6 males but not observed in mice from F1 or F2 heterozygous matings to chimeric males or 129P2/OlaHsd males
abnormal rectum morphology ( J:33951 )
• narrow rectum

growth/size/body
decreased body size ( J:33951 )
• by 2-3 days of age, males are smaller and appear wasted
decreased body weight ( J:33951 )
• body weight at P5 is 50% that of wild-type

immune system
small thymus ( J:33951 )
• 10% smaller thymus compared to wild-type

muscle
abnormal muscle morphology ( J:33951 )
• muscle rigidity

hematopoietic system
small thymus ( J:33951 )
• 10% smaller thymus compared to wild-type

endocrine/exocrine glands
small thymus ( J:33951 )
• 10% smaller thymus compared to wild-type




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory