Phenotypes associated with this allele

• Allele Symbol: Scn10a^tm1Jwo
• Allele Name: targeted mutation 1, John N Wood
• Allele ID: MGI:2180183
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scn10a^tm1Jwo/Scn10a^tm1Jwo	B6.129P2-Scn10a^tm1Jwo	MGI:2181753

Genotype
MGI:2181753

hm1

• Allelic Composition: Scn10a^tm1Jwo/Scn10a^tm1Jwo
• Genetic Background: B6.129P2-Scn10a^tm1Jwo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal mechanical nociception ( J:76456 )

• pronounced deficiencies in response to tail pressure were noted

hypoalgesia ( J:76456 )

• delayed development of inflammatory hyperalgesia

abnormal thermal nociception ( J:76456 )

• latency in paw-withdrawal and tail flick tests after exposure to radiant heat was increased in mutant mice, although no differences were observed in a hot plate test