Phenotypes associated with this allele

• Allele Symbol: Tnfsf14^tm1Lpc
• Allele Name: targeted mutation 1, Lieping Chen
• Allele ID: MGI:2180198
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnfsf14^tm1Lpc/Tnfsf14^tm1Lpc	B6.129X1-Tnfsf14^tm1Lpc	MGI:4453326
hm2	Tnfsf14^tm1Lpc/Tnfsf14^tm1Lpc	involves: 129X1/SvJ * C57BL/6	MGI:3849749
cx3	Lta^tm1Dch/Lta^tm1Dch Tnfsf14^tm1Lpc/Tnfsf14^tm1Lpc	involves: 129S2/SvPas * 129X1/SvJ	MGI:5013461

Genotype
MGI:4453326

hm1

• Allelic Composition: Tnfsf14^tm1Lpc/Tnfsf14^tm1Lpc
• Genetic Background: B6.129X1-Tnfsf14^tm1Lpc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:158663 )

N • susceptibility to Citrobacter rodentium infection is similar to wild-type controls

Genotype
MGI:3849749

hm2

• Allelic Composition: Tnfsf14^tm1Lpc/Tnfsf14^tm1Lpc
• Genetic Background: involves: 129X1/SvJ * C57BL/6

immune system

abnormal cytotoxic T cell physiology ( J:76414 )

• there is a decrease of about a third in the number of CD8⁺ T cells that activate and proliferate in response to S. aureus superantigen

• production of IFN-gamma and TNF is impaired

decreased cytotoxic T cell cytolysis ( J:76414 )

• cytolytic activity is reduced by half to a third in vitro

decreased interferon-gamma secretion ( J:76414 )

• IFN-gamma secretion by activated CD8⁺ T cells is impaired in vitro

decreased tumor necrosis factor secretion ( J:76414 )

• TNF secretion by activated CD8⁺ T cells is impaired in vitro

decreased inflammatory response ( J:107803 )

• mice are resistant to a hepatitis model induced by injections of concanavalin A (ConA)

• less than 10% of mice die after a lethal dose of ConA compared to 80% of control mice

• mice are also resistant to a second hepatitis model induced by Listeria monocytogenes infection with half the mice alive 200 hours after infection compared to less than 10% of controls

hematopoietic system

abnormal cytotoxic T cell physiology ( J:76414 )

• there is a decrease of about a third in the number of CD8⁺ T cells that activate and proliferate in response to S. aureus superantigen

• production of IFN-gamma and TNF is impaired

decreased cytotoxic T cell cytolysis ( J:76414 )

• cytolytic activity is reduced by half to a third in vitro

Genotype
MGI:5013461

cx3

• Allelic Composition: Lta^tm1Dch/Lta^tm1Dch; Tnfsf14^tm1Lpc/Tnfsf14^tm1Lpc
• Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

hematopoietic system

abnormal thymus epithelium morphology ( J:173115 )

• more disorganized medullary thymic epithelial cells than in Lta^tm1Dch homozygotes

small thymus medulla ( J:173115 )

• smaller than in Lta^tm1Dch homozygotes

abnormal lymphocyte morphology ( J:173115 )

• mice exhibit accumulation of lymphoid cell aggregates (B220+, CD4+, and CD8+ lymphocytes) in the liver and lung unlike in wild-type mice

immune system

abnormal thymus epithelium morphology ( J:173115 )

• more disorganized medullary thymic epithelial cells than in Lta^tm1Dch homozygotes

small thymus medulla ( J:173115 )

• smaller than in Lta^tm1Dch homozygotes

abnormal lymphocyte morphology ( J:173115 )

• mice exhibit accumulation of lymphoid cell aggregates (B220+, CD4+, and CD8+ lymphocytes) in the liver and lung unlike in wild-type mice

endocrine/exocrine glands

abnormal thymus epithelium morphology ( J:173115 )

• more disorganized medullary thymic epithelial cells than in Lta^tm1Dch homozygotes

small thymus medulla ( J:173115 )

• smaller than in Lta^tm1Dch homozygotes