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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Defb1tm1Hgu
targeted mutation 1, MRC Human Genetics Unit
MGI:2180302
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Defb1tm1Hgu/Defb1tm1Hgu involves: 129P2/OlaHsd * C57BL/6N MGI:3845055


Genotype
MGI:3845055
hm1
Allelic
Composition		 Defb1tm1Hgu/Defb1tm1Hgu
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Defb1tm1Hgu mutation (0 available); any Defb1 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal urinary bladder physiology ( J:76528 )
• bladder urine bacteria content is increased compared to in wild-type mice
• bladder urine contains more Staphylococcus bacteria than in wild-type urine

immune system
immune system phenotype ( J:76528 )
N
• mice exhibit normal bronchoalveolar lavage fluid and normal clearance of S. aureus from airways




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory