Phenotypes associated with this allele

• Allele Symbol: Arg2^tm1Weo
• Allele Name: targeted mutation 1, William E O'Brien
• Allele ID: MGI:2180319
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arg2^tm1Weo/Arg2^tm1Weo	involves: C57BL/6J	MGI:2655502
ht2	Arg2^tm1Weo/Arg2^+	involves: C57BL/6J	MGI:3043772

Genotype
MGI:2655502

hm1

• Allelic Composition: Arg2^tm1Weo/Arg2^tm1Weo
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:67353 )

N • analysis of polyamines in brain, liver, kidney, and testes, as well as cultured skin fibroblasts, revealed no significant differences between mutant and wild-type mice

N • homozygous mutants displayed normal plasma citrulline and proline levels, and normal urinary amino acid levels

N • homozygotes displayed a trend toward elevated ornithine levels, but the differences were not statistically significant

increased circulating arginine level ( J:67353 )

• at 8-10 weeks, adult homozygous mutant mice displayed a significant elevation of plasma arginine levels (hyperargininemia) relative to wild-type

Genotype
MGI:3043772

ht2

• Allelic Composition: Arg2^tm1Weo/Arg2⁺
• Genetic Background: involves: C57BL/6J

homeostasis/metabolism

increased circulating arginine level ( J:67353 )

• at 8-10 weeks, adult heterozygous mutant mice displayed a significant elevation of plasma arginine levels (hyperargininemia) relative to wild-type