Phenotypes associated with this allele

• Allele Symbol: Phox2a^tm1Jbr
• Allele Name: targeted mutation 1, Jean-Francois Brunet
• Allele ID: MGI:2180328
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Phox2a^tm1Jbr/Phox2a^tm1Jbr	involves: 129P2/OlaHsd	MGI:4438208
hm2	Phox2a^tm1Jbr/Phox2a^tm1Jbr	involves: 129P2/OlaHsd * C57BL/6	MGI:3845086
ht3	Phox2a^tm1Jbr/Phox2a^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3845087

Genotype
MGI:4438208

hm1

• Allelic Composition: Phox2a^tm1Jbr/Phox2a^tm1Jbr
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal pterygopalatine ganglion morphology ( J:157532 )

• sphenopalatine ganglion is absent

abnormal sublingual ganglion morphology ( J:157532 )

• lingual ganglia is absent in some mice

abnormal submandibular ganglion morphology ( J:157532 )

• absent in some mice

abnormal facial nerve morphology ( J:157532 )

• corda tympani is absent in some mice

• greater superficial petrosal nerve is absent

Genotype
MGI:3845086

hm2

• Allelic Composition: Phox2a^tm1Jbr/Phox2a^tm1Jbr
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

nervous system

abnormal autonomic nervous system morphology ( J:39084 )

abnormal parasympathetic ganglion morphology ( J:39084 )

abnormal otic ganglion morphology ( J:39084 )

• absent

abnormal pterygopalatine ganglion morphology ( J:39084 )

• absent

small submandibular ganglion ( J:39084 )

• sometimes reduced

small superior cervical ganglion ( J:39084 )

• reduced in size at E13.5 and a second cervical ganglion is present

• size difference is not significant at birth

abnormal locus ceruleus morphology ( J:39084 )

• absent

abnormal cranial ganglia morphology ( J:39084 )

small geniculate ganglion ( J:39084 )

• at E13.5

• normal at E10.5

small petrosal ganglion ( J:39084 )

• massive apoptosis at E11.5

• severely reduced by 77% at E13.5

• normal at E10.5

small nodose ganglion ( J:39084 )

• massive apoptosis at E11.5

• severely reduced by 77% at E13.5

• normal at E10.5

Genotype
MGI:3845087

ht3

• Allelic Composition: Phox2a^tm1Jbr/Phox2a⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

respiratory system

increased tidal volume ( J:121653 )

• tidal volume shows a greater initial increase under hypoxic conditions than controls

increased pulmonary respiratory rate ( J:121653 )

• breathing frequency shows a greater initial increase under hypoxic conditions than controls

increased pulmonary ventilation ( J:121653 )

• volume of air per minute is higher than controls at birth, 5, and 10 days of age

• due to breathing amplitude (vol/g) rather than frequency differences

• duration of inspiration remains long over the first five days of life before declining