Phenotypes associated with this allele

• Allele Symbol: Phox2a^tm1.1Sgu
• Allele Name: targeted mutation 1.1, Sarah Guthrie
• Allele ID: MGI:2180355
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Phox2a^tm1.1Sgu/Phox2a^tm1.1Sgu	involves: 129P2/OlaHsd * C57BL/6	MGI:3845071
hm2	Phox2a^tm1.1Sgu/Phox2a^tm1.1Sgu	involves: 129P2/OlaHsd * C57BL/6J	MGI:5287991
cx3	Ascl1^tm1And/Ascl1^tm1And Phox2a^tm1.1Sgu/Phox2a^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3845072

Genotype
MGI:3845071

hm1

• Allelic Composition: Phox2a^tm1.1Sgu/Phox2a^tm1.1Sgu
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal autonomic nervous system morphology ( J:63720 )

• sympathetic axons that normally join the greater superficial petrosal nerve (GSPN) stop at the point at which they normally join

abnormal parasympathetic ganglion morphology ( J:63720 )

abnormal otic ganglion morphology ( J:63720 )

• sometimes atrophic or missing

• a conspicuous connection exists between the otic ganglion, if present and the geniculate ganglion at E16.5

abnormal pterygopalatine ganglion morphology ( J:63720 )

• absent

small submandibular ganglion ( J:63720 )

• sometimes atrophic

small superior cervical ganglion ( J:63720 )

abnormal locus ceruleus morphology ( J:63720 )

• absent

abnormal cranial ganglia morphology ( J:63720 )

small geniculate ganglion ( J:63720 )

• atrophic

• a conspicuous connection exists between the otic ganglion, if present and the geniculate ganglion at E16.5

small petrosal ganglion ( J:63720 )

• atrophic

small trigeminal ganglion ( J:63720 )

• atrophic

small nodose ganglion ( J:63720 )

abnormal facial nerve morphology ( J:63720 )

• greater superficial petrosal nerve (GSPN) is truncated close to the geniculate ganglion at E13.5

• GSPN is always less than 1/8 normal length

respiratory system

abnormal respiration ( J:89905 )

• duration of the respiratory cycle is more irregular for E18 preterm neonates

decreased pulmonary respiratory rate ( J:89905 )

• mean respiratory frequency is reduced for E18 preterm neonates

Genotype
MGI:5287991

hm2

• Allelic Composition: Phox2a^tm1.1Sgu/Phox2a^tm1.1Sgu
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

nervous system

abnormal neuron differentiation ( J:175535 )

• cells fated to become ocular motor neurons develop into red nucleus neurons

decreased motor neuron number ( J:175535 )

• decrease in the number of ocular motor neurons at E11.25

increased neuron number ( J:175535 )

• increase in the number of red nucleus neurons at E11.25

cellular

abnormal neuron differentiation ( J:175535 )

• cells fated to become ocular motor neurons develop into red nucleus neurons

Genotype
MGI:3845072

cx3

• Allelic Composition: Ascl1^tm1And/Ascl1^tm1And; Phox2a^tm1.1Sgu/Phox2a⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

nervous system

nervous system phenotype ( J:63720 )

N • normal greater superficial petrosal nerve (GSPN) at E14.5

growth/size/body

fetal growth retardation ( J:63720 )

• at E14.5