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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnp2tm1Mzh
targeted mutation 1, Ming Zhao
MGI:2180358
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tnp2tm1Mzh/Tnp2tm1Mzh involves: 129S/SvEv * 129S7/SvEvBrd MGI:3037930
hm2
 		Tnp2tm1Mzh/Tnp2tm1Mzh involves: 129S7/SvEvBrd * C57BL/6J MGI:3037931


Genotype
MGI:3037930
hm1
Allelic
Composition		 Tnp2tm1Mzh/Tnp2tm1Mzh
Genetic
Background		 involves: 129S/SvEv * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnp2tm1Mzh mutation (1 available); any Tnp2 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
teratozoospermia ( J:72107 )
• significant increase in sperm flagellum, but not head, abnormalities relative to wild-type or heterozygous mice
abnormal outer dense fiber morphology ( J:72107 )
• sperm with unraveled outer dense fibers are observed
abnormal sperm axoneme morphology ( J:72107 )
• significant increase in the number of sperm with unraveled axoneme and/or outer dense fibers (14%) relative to wild-type controls (2%)
abnormal sperm midpiece morphology ( J:72107 )
• significant increase in number of sperm with bent midpieces (26%) relative to wild-type controls (5%)
abnormal sperm nucleus morphology ( J:72107 )
• aberrant focal condensations of chromatin in step 11 to 13 spermatids
• progressive chromatin condensation in later spermatids, but incomplete condensation in epididymal sperm
• sperm chromatin is more accessible to intercalating dyes and more susceptible to acid denaturation, suggesting DNA strand breaks
asthenozoospermia ( J:72107 )
• sperm retention was noted on seminiferous tubules
decreased litter size ( J:72107 )
• the litter size produced from matings involving homozygous males was almost half the size of controls

cellular
teratozoospermia ( J:72107 )
• significant increase in sperm flagellum, but not head, abnormalities relative to wild-type or heterozygous mice
abnormal outer dense fiber morphology ( J:72107 )
• sperm with unraveled outer dense fibers are observed
abnormal sperm axoneme morphology ( J:72107 )
• significant increase in the number of sperm with unraveled axoneme and/or outer dense fibers (14%) relative to wild-type controls (2%)
abnormal sperm midpiece morphology ( J:72107 )
• significant increase in number of sperm with bent midpieces (26%) relative to wild-type controls (5%)
abnormal sperm nucleus morphology ( J:72107 )
• aberrant focal condensations of chromatin in step 11 to 13 spermatids
• progressive chromatin condensation in later spermatids, but incomplete condensation in epididymal sperm
• sperm chromatin is more accessible to intercalating dyes and more susceptible to acid denaturation, suggesting DNA strand breaks
asthenozoospermia ( J:72107 )
• sperm retention was noted on seminiferous tubules




Genotype
MGI:3037931
hm2
Allelic
Composition		 Tnp2tm1Mzh/Tnp2tm1Mzh
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnp2tm1Mzh mutation (1 available); any Tnp2 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:72107 )
• although a trend toward reduced litter size and abnormal sperm morphology was noted, the differences from controls were not statistically significant




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory