All Phenotypes Tnp2<tm1Mzh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tnp2^tm1Mzh
targeted mutation 1, Ming Zhao
MGI:2180358

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnp2^tm1Mzh/Tnp2^tm1Mzh	involves: 129S/SvEv * 129S7/SvEvBrd	MGI:3037930
hm2	Tnp2^tm1Mzh/Tnp2^tm1Mzh	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3037931

Allelic Composition	Tnp2^tm1Mzh/Tnp2^tm1Mzh
Genetic Background	involves: 129S/SvEv * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnp2^tm1Mzh mutation (1 available); any Tnp2 mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

teratozoospermia ( J:72107 )

• significant increase in sperm flagellum, but not head, abnormalities relative to wild-type or heterozygous mice

abnormal outer dense fiber morphology ( J:72107 )

• sperm with unraveled outer dense fibers are observed

abnormal sperm axoneme morphology ( J:72107 )

• significant increase in the number of sperm with unraveled axoneme and/or outer dense fibers (14%) relative to wild-type controls (2%)

abnormal sperm midpiece morphology ( J:72107 )

• significant increase in number of sperm with bent midpieces (26%) relative to wild-type controls (5%)

abnormal sperm nucleus morphology ( J:72107 )

• aberrant focal condensations of chromatin in step 11 to 13 spermatids

• progressive chromatin condensation in later spermatids, but incomplete condensation in epididymal sperm

• sperm chromatin is more accessible to intercalating dyes and more susceptible to acid denaturation, suggesting DNA strand breaks

asthenozoospermia ( J:72107 )

• sperm retention was noted on seminiferous tubules

decreased litter size ( J:72107 )

• the litter size produced from matings involving homozygous males was almost half the size of controls

cellular

teratozoospermia ( J:72107 )

• significant increase in sperm flagellum, but not head, abnormalities relative to wild-type or heterozygous mice

abnormal outer dense fiber morphology ( J:72107 )

• sperm with unraveled outer dense fibers are observed

abnormal sperm axoneme morphology ( J:72107 )

• significant increase in the number of sperm with unraveled axoneme and/or outer dense fibers (14%) relative to wild-type controls (2%)

abnormal sperm midpiece morphology ( J:72107 )

• significant increase in number of sperm with bent midpieces (26%) relative to wild-type controls (5%)

abnormal sperm nucleus morphology ( J:72107 )

• aberrant focal condensations of chromatin in step 11 to 13 spermatids

• progressive chromatin condensation in later spermatids, but incomplete condensation in epididymal sperm

• sperm chromatin is more accessible to intercalating dyes and more susceptible to acid denaturation, suggesting DNA strand breaks

asthenozoospermia ( J:72107 )

• sperm retention was noted on seminiferous tubules

Allelic Composition	Tnp2^tm1Mzh/Tnp2^tm1Mzh
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnp2^tm1Mzh mutation (1 available); any Tnp2 mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:72107 )

• although a trend toward reduced litter size and abnormal sperm morphology was noted, the differences from controls were not statistically significant

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