Phenotypes associated with this allele

• Allele Symbol: Atf4^tm1Jml
• Allele Name: targeted mutation 1, Jeffrey M Leiden
• Allele ID: MGI:2180371
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atf4^tm1Jml/Atf4^tm1Jml	involves: 129X1/SvJ	MGI:3757684
cx2	Atf4^tm1Jml/Atf4^tm1Jml Trp53^tm1Brd/Trp53^tm1Brd	involves: 129S7/SvEvBrd * 129X1/SvJ	MGI:3757692

Genotype
MGI:3757684

hm1

• Allelic Composition: Atf4^tm1Jml/Atf4^tm1Jml
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:62578 )

• partial penetrance: the number of E18.5 to P1 mutants is reduced and only 30% of homozygotes survive until adulthood

growth/size/body

decreased body size ( J:62578 )

• surviving homozygotes are runted

decreased fetal size ( J:62578 )

• E17.5 mutants are runted

vision/eye

abnormal ciliary body morphology ( J:62578 )

• small and malformed

abnormal iris morphology ( J:62578 )

• small and malformed

aphakia ( J:62578 )

• lens development is normal between E12.5 and 14.5, however by E15.5-16.5, the anterior lens cells undergo massive and synchronous apoptosis resulting in the absence of the lens in adults

microphthalmia ( J:62578 )

eyelids fail to open ( J:62578 )

Genotype
MGI:3757692

cx2

• Allelic Composition: Atf4^tm1Jml/Atf4^tm1Jml; Trp53^tm1Brd/Trp53^tm1Brd
• Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

vision/eye

vision/eye phenotype ( J:62578 )

N • eye and eyelid morphology are normal and there is a marked suppression in the microphthalmia that is seen in single Atf4 homozygotes

abnormal lens morphology ( J:62578 )

• lenses are present, however they show an increased number of cells in the bow region

abnormal lens fiber morphology ( J:62578 )

• decrease in numbers of lens fiber cells