Phenotypes associated with this allele

• Allele Symbol: Atp2a3^tm1Ges
• Allele Name: targeted mutation 1, Gary E Shull
• Allele ID: MGI:2180376
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atp2a3^tm1Ges/Atp2a3^tm1Ges	involves: Black Swiss	MGI:2655643

Genotype
MGI:2655643

hm1

• Allelic Composition: Atp2a3^tm1Ges/Atp2a3^tm1Ges
• Genetic Background: involves: Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal muscle relaxation ( J:44333 )

• aortic rings first stimulated to 80-90% of maximum contraction with phenylephrine show reduced relaxation in response to increasing concentrations of acetylcholine (Ach), however both wild-type and mutant aortas fail to respond to Ach when denuded of endothelium, indicating that endothelium-dependent relaxation is reduced in aortas

cardiovascular system

abnormal vascular endothelial cell physiology ( J:44333 )

• mutant aortic endothelial cells show only a minimal increase in acetylcholine-induced intracellular calcium levels compared to a pronounced increase in wild-type cells and impaired replenishment of the acetylcholine-responsive calcium stores