All Phenotypes Sim1<tm1Fan> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sim1^tm1Fan
targeted mutation 1, Chen-Ming Fan
MGI:2180390

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sim1^tm1Fan/Sim1^tm1Fan	involves: 129/Sv * C57BL/6	MGI:3036851
hm2	Sim1^tm1Fan/Sim1^tm1Fan	involves: 129S1/Sv * 129X1/SvJ	MGI:3613778
ht3	Sim1^tm1Fan/Sim1⁺	involves: 129/Sv * C57BL/6	MGI:3036852
cx4	Sim1^tm1Fan/Sim1⁺ Sim2^tm1Fan/Sim2⁺	involves: 129/Sv * C57BL/6	MGI:3036853
cx5	Sim1^tm1Fan/Sim1^tm1Fan Sim2^tm1Fan/Sim2^tm1Fan	involves: 129S1/Sv * 129X1/SvJ	MGI:3613779
cx6	Sim1^tm1Fan/Sim1^tm1Fan Sim2^tm1Fan/Sim2⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:3613780
cx7	Sim1^tm1Fan/Sim1⁺ Sim2^tm1Fan/Sim2^tm1Fan	involves: 129S1/Sv * 129X1/SvJ	MGI:3613782
cx8	Sim1^tm1Fan/Sim1^tm1Jlmd Sim2^tm1Fan/Sim2^tm1Fan	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3613785

Allelic Composition	Sim1^tm1Fan/Sim1^tm1Fan
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sim1^tm1Fan mutation (0 available); any Sim1 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:50772 )

• homozygotes survived to birth but died within the first 24 hours after birth

endocrine/exocrine glands

absent magnocellular neurosecretory cells ( J:50772 )

abnormal pituicyte morphology ( J:50772 )

• absence of axonal projections from the paraventricular and supraoptic nuclei results in more densly packed pituicytes in the posterior lobe of the pituitary

pituitary gland hypoplasia ( J:50772 )

• average number of cells in midsagittal sections of the pituitary are reduced by about 50%

nervous system

abnormal diencephalon morphology ( J:50772 )

• paraventricular nucleus and supraoptic nuclei are hypocellular

• magnocellular neurons are absent

• terminal differentiation of neurons in both nuclei fails

absent magnocellular neurosecretory cells ( J:50772 )

abnormal pituicyte morphology ( J:50772 )

• absence of axonal projections from the paraventricular and supraoptic nuclei results in more densly packed pituicytes in the posterior lobe of the pituitary

pituitary gland hypoplasia ( J:50772 )

• average number of cells in midsagittal sections of the pituitary are reduced by about 50%

abnormal paraventricular hypothalamic nucleus morphology ( J:50772 )

• hypocellular

• absence of axonal projections from the paraventricular nuclei

abnormal supraoptic nucleus morphology ( J:50772 )

• hypocellular

• absence of axonal projections from the supraoptic nuclei

Allelic Composition	Sim1^tm1Fan/Sim1^tm1Fan
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sim1^tm1Fan mutation (0 available); any Sim1 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal nervous system tract morphology ( J:104419 )

• at E18.5, the principal mammillary axonal tract appears less prominent

Allelic Composition	Sim1^tm1Fan/Sim1⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sim1^tm1Fan mutation (0 available); any Sim1 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

abnormal brown adipose tissue morphology ( J:70586 )

• cells are larger

increased brown adipose tissue amount ( J:70586 )

• mass of brown fat was increased

abnormal white adipose tissue morphology ( J:70586 )

• white adipose tissue cells are histologically normal

increased white adipose tissue amount ( J:70586 )

• increased mass of white fat due to increased number of cells

behavior/neurological

polyphagia ( J:70586 )

• food intake increased around 4-5 weeks of age

• hyperphagia persists over time

growth/size/body

increased body length ( J:70586 )

• heterozygotes have a greater naso-anal length after 4 weeks than do controls

increased susceptibility to weight gain ( J:70586 )

• while growth is normal until 4 weeks of age, weight gain after that time is elevated in both males and females

homeostasis/metabolism

abnormal glucose homeostasis ( J:70586 )

• blood glucose levels were normal at 8 and 24 weeks of age

increased circulating insulin level ( J:70586 )

• although normal at 8 weeks, insulin levels were significantly elevated by 24 weeks of age

• while growth is normal until 4 weeks of age, weight gain after that time is elevated in both males and females

nervous system

abnormal diencephalon morphology ( J:50772 )

• paraventricular nucleus and supraoptic nuclei are hypocellular

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:70586

Allelic Composition	Sim1^tm1Fan/Sim1⁺ Sim2^tm1Fan/Sim2⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sim1^tm1Fan mutation (0 available); any Sim1 mutation (52 available)
Sim2^tm1Fan mutation (0 available); any Sim2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased susceptibility to weight gain ( J:76787 )

• after 7 months the average weight was identical to that of mice heterozygous only for Sim1^tm1Fan

nervous system

abnormal diencephalon morphology ( J:76787 )

• paraventricular nucleus and supraoptic nuclei are hypocellular

• the phenotype is identical to that of mice heterozygous only for Sim1^tm1Fan

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:76787

Allelic Composition	Sim1^tm1Fan/Sim1^tm1Fan Sim2^tm1Fan/Sim2^tm1Fan
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal nervous system tract morphology ( J:104419 )

• at E18.5, the principal mammillary axonal tract appears thin and the mammilothalmic tract is undetectable

• most mammillary body axons are directed towards the midline with some becoming splayed and others forming a bundle that crosses the midline ventrally

Allelic Composition	Sim1^tm1Fan/Sim1^tm1Fan Sim2^tm1Fan/Sim2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal nervous system tract morphology ( J:104419 )

• at E18.5, the principal mammillary axonal tract appears less prominent similar to mice homozygous for Sim1^tm1Fan alone

Allelic Composition	Sim1^tm1Fan/Sim1⁺ Sim2^tm1Fan/Sim2^tm1Fan
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal nervous system tract morphology ( J:104419 )

• at E18.5, the principal mammillary axonal tract appears less prominent similar to mice homozygous for Sim1^tm1Fan alone

Allelic Composition	Sim1^tm1Fan/Sim1^tm1Jlmd Sim2^tm1Fan/Sim2^tm1Fan
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sim1^tm1Fan mutation (0 available); any Sim1 mutation (52 available)
Sim1^tm1Jlmd mutation (0 available); any Sim1 mutation (52 available)
Sim2^tm1Fan mutation (0 available); any Sim2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon morphology ( J:104419 )

• at E11.5 mammillary body axon bundles are not detectable

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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