All Phenotypes Bglap/Bglap2<tm1Kry> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bglap/Bglap2^tm1Kry/Bglap/Bglap2^tm1Kry	involves: 129S7/SvEvBrd	MGI:3763090
hm2	Bglap/Bglap2^tm1Kry/Bglap/Bglap2^tm1Kry	involves: 129S7/SvEvBrd * C57BL/6	MGI:3837364
cn3	Bglap/Bglap2^tm1Kry/Bglap2⁺ Ptprv^tm1Kry/Ptprv^tm1Kry Tg(Col1a1-cre)1Kry/0	involves: 129S7/SvEvBrd * FVB	MGI:3763095
cn4	Bglap/Bglap2^tm1Kry/Bglap2⁺ Ggcx^tm1.1Kry/Ggcx^tm1.1Kry Tg(BGLAP-cre)1Clem/0	involves: 129S7/SvEvBrd * FVB/NJ	MGI:6198741
cx5	Adipoq^tm1Ish/Adipoq⁺ Bglap/Bglap2^tm1Kry/Bglap2⁺	involves: 129S7/SvEvBrd	MGI:3763091
cx6	Bglap/Bglap2^tm1Kry/Bglap/Bglap2^tm1Kry Lep^ob/Lep^ob	involves: 129S7/SvEvBrd * C57BL/10J	MGI:3837375
cx7	Bglap/Bglap2^tm1Kry/Bglap/Bglap2^tm1Kry Tg(AZIP/F)1Vsn/0	involves: 129S7/SvEvBrd * FVB/N	MGI:3837378

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased adipocyte glucose uptake ( J:126780 )

• white adipose glucose uptake, 7.5+/-0.9 nmol/g/min compared to 16.7+/-2.7 nmol/g/min in wild-type mice

oligozoospermia ( J:170888 )

• worsening with time

abnormal spermatid morphology ( J:170888 )

• decreased numbers

abnormal spermatocyte morphology ( J:170888 )

• decreased numbers

decreased pancreatic beta cell proliferation ( J:126780 )

• beta-cell proliferation is decreased by two-fold compared to in wild-type mice

reproductive system

reproductive system phenotype ( J:170888 )

N	• female mice exhibit normal female fertility, ovary weight, morphology of the uterus, follicles number, and circulating levels of sex steroid hormones • male germ cell proliferation is normal

oligozoospermia ( J:170888 )

• worsening with time

abnormal spermatid morphology ( J:170888 )

• decreased numbers

abnormal spermatocyte morphology ( J:170888 )

• decreased numbers

decreased seminal vesicle weight ( J:170888 )

• worsening with time

abnormal seminiferous tubule epithelium morphology ( J:170888 )

• the size of the epithelium in testis tubules is decreased compared to in wild-type mice

decreased Leydig cell number ( J:170888 )

small testis ( J:170888 )

• at 3 months of age

decreased testis weight ( J:170888 )

• at 3 months of age

decreased epididymis weight ( J:170888 )

• worsening with time

homeostasis/metabolism

decreased circulating testosterone level ( J:170888 )

increased circulating estradiol level ( J:170888 )

increased circulating luteinizing hormone level ( J:170888 )

• 2.5-fold

increased circulating triglyceride level ( J:126780 )

decreased energy expenditure ( J:126780 )

abnormal glucose homeostasis ( J:126780 )

decreased insulin secretion ( J:126780 )

• mice exhibit decreased insulin secretion

• however, treatment of mice with recombinant osteocalcin increases insulin secretion

increased circulating glucose level ( J:126780 )

decreased circulating insulin level ( J:126780 )

impaired glucose tolerance ( J:126780 )

insulin resistance ( J:126780 )

adipose tissue

increased total body fat amount ( J:126780 )

abnormal fat cell morphology ( J:126780 )

• adipocyte number is increased (125.6+/-10.6x10³ adipocytes per fat pad compared to 93.2+/-10.7x10³ adipocytes per fat pad in wild-type mice)

decreased adipocyte glucose uptake ( J:126780 )

• white adipose glucose uptake, 7.5+/-0.9 nmol/g/min compared to 16.7+/-2.7 nmol/g/min in wild-type mice

endocrine/exocrine glands

decreased pancreatic beta cell proliferation ( J:126780 )

• beta-cell proliferation is decreased by two-fold compared to in wild-type mice

abnormal pancreatic islet morphology ( J:126780 )

• mice exhibit decreased islet size and number, beta-cell mass, and pancreas insulin content

decreased pancreatic beta cell mass ( J:126780 )

• mice exhibit decreased beta-cell mass

decreased pancreatic islet number ( J:126780 )

small pancreatic islets ( J:126780 )

decreased seminal vesicle weight ( J:170888 )

• worsening with time

abnormal seminiferous tubule epithelium morphology ( J:170888 )

• the size of the epithelium in testis tubules is decreased compared to in wild-type mice

decreased Leydig cell number ( J:170888 )

small testis ( J:170888 )

• at 3 months of age

decreased testis weight ( J:170888 )

• at 3 months of age

decreased insulin secretion ( J:126780 )

• mice exhibit decreased insulin secretion

• however, treatment of mice with recombinant osteocalcin increases insulin secretion

Allelic Composition	Bglap/Bglap2^tm1Kry/Bglap/Bglap2^tm1Kry
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bglap/Bglap2^tm1Kry mutation (1 available); any Bglap2 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal long bone diaphysis morphology ( J:34440 )

• increase in the width of the diaphysis is observed at 9 months of age

abnormal bone structure ( J:34440 )

• long bones of ovariectomized mutants show a greater decrease in bone density, yield energy, failure load and stiffness than wild-type bones, indicating bone fragility similar to osteoporosis after ovariectomy

increased osteoclast cell number ( J:34440 )

• increase in osteoclast number and surface

increased compact bone thickness ( J:34440 )

• width of cortical bone is increased at 6 months of age, reaching 150% of the wild-type width by 9 months of age

increased trabecular bone thickness ( J:34440 )

• mutants contain more cancellous bone than wild-type mice at 6 and 9 months of age

increased bone mass ( J:34440 )

abnormal skeleton development ( J:34440 )

• cancellous and cortical bone formation rates are increased in long bones and vertebrae

abnormal bone remodeling ( J:34440 )

• develop bone remodeling abnormalities by 6 months of age

increased bone strength ( J:34440 )

• 6 month old mice show a significant increase in failure load, indicating increased bone strength

hematopoietic system

increased osteoclast cell number ( J:34440 )

• increase in osteoclast number and surface

immune system

increased osteoclast cell number ( J:34440 )

• increase in osteoclast number and surface

Allelic Composition	Bglap/Bglap2^tm1Kry/Bglap2⁺ Ptprv^tm1Kry/Ptprv^tm1Kry Tg(Col1a1-cre)1Kry/0
Genetic Background	involves: 129S7/SvEvBrd * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bglap/Bglap2^tm1Kry mutation (1 available); any Bglap2 mutation (9 available)
Ptprv^tm1Kry mutation (0 available); any Ptprv mutation (30 available)
Tg(Col1a1-cre)1Kry mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:126780 )

N	• unlike in Ptprv^tm1Kry/ Ptprv^tm1Kry Tg(Col1a1-cre)1Kry mice, beta-cell proliferation is normal

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:126780 )

N	• unlike in Ptprv^tm1Kry/ Ptprv^tm1Kry Tg(Col1a1-cre)1Kry mice, glucose homeostasis is normal

Allelic Composition	Bglap/Bglap2^tm1Kry/Bglap2⁺ Ggcx^tm1.1Kry/Ggcx^tm1.1Kry Tg(BGLAP-cre)1Clem/0
Genetic Background	involves: 129S7/SvEvBrd * FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bglap/Bglap2^tm1Kry mutation (1 available); any Bglap2 mutation (9 available)
Ggcx^tm1.1Kry mutation (0 available); any Ggcx mutation (37 available)
Tg(BGLAP-cre)1Clem mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:264734 )

N	• glucose tolerance is normal

Allelic Composition	Adipoq^tm1Ish/Adipoq⁺ Bglap/Bglap2^tm1Kry/Bglap2⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adipoq^tm1Ish mutation (0 available); any Adipoq mutation (41 available)
Bglap/Bglap2^tm1Kry mutation (1 available); any Bglap2 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

insulin resistance ( J:126780 )

• mice exhibit decreased insulin sensitivity

• however, blood glucose levels, insulin serum levels, and insulin secretion are normal

decreased circulating adiponectin level ( J:126780 )

Allelic Composition	Bglap/Bglap2^tm1Kry/Bglap/Bglap2^tm1Kry Lep^ob/Lep^ob
Genetic Background	involves: 129S7/SvEvBrd * C57BL/10J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bglap/Bglap2^tm1Kry mutation (1 available); any Bglap2 mutation (9 available)
Lep^ob mutation (5 available); any Lep mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:145998 )

N	• beta-cell proliferation is normal

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:145998 )

N	• serum insulin and blood glucose levels are normal

Allelic Composition	Bglap/Bglap2^tm1Kry/Bglap/Bglap2^tm1Kry Tg(AZIP/F)1Vsn/0
Genetic Background	involves: 129S7/SvEvBrd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bglap/Bglap2^tm1Kry mutation (1 available); any Bglap2 mutation (9 available)
Tg(AZIP/F)1Vsn mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating insulin level ( J:145998 )

• mice exhibit elevated serum insulin levels compared to in wild-type mice that are half as much as in Tg(AZIP/F)1Vsn mice

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