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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Capn1tm1Ahc
targeted mutation 1, Athar H Chishti
MGI:2180538
Summary 5 genotypes


Genotype
MGI:2659040
hm1
Allelic
Composition		 Capn1tm1Ahc/Capn1tm1Ahc
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capn1tm1Ahc mutation (1 available); any Capn1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:67798 )
N
• homozygotes displayed normal bleeding times
• at 8-12 weeks of age, homozygotes had normal platelet numbers in peripheral blood
• early events of platelet activation (e.g. shape change and granule release) and the initial rate of platelet aggregation appeared normal
• no differences were detected in the cleavage pattern and kinetics of calpain substrates
abnormal platelet physiology ( J:67798 )
• platelets showed impaired tyrosine phosphorylation of several proteins upon activation with either calcium ionophore or thrombin, including the beta3 subunit of alphaIIb-beta3 integrin (~70% reduction)
decreased platelet aggregation ( J:67798 )
• platelet aggregation was decreased by 50-60% in response to thrombin (10 nM), ADP (20 uM), collagen (20 ug/ml), and calcium ionophore A23187 (1.0 uM)
abnormal platelet dense granule physiology ( J:67798 )
• subtle differences were detected in the ATP secretion from dense granules upon thrombin and collagen activation; no differences were detected in the ADP- and calcium ionophore A23187-treated platelets

homeostasis/metabolism
abnormal blood coagulation ( J:67798 )
• platelets were defective in retracting clots, especially when clot formation was induced with 1.0 nM thrombin
abnormal platelet physiology ( J:67798 )
• platelets showed impaired tyrosine phosphorylation of several proteins upon activation with either calcium ionophore or thrombin, including the beta3 subunit of alphaIIb-beta3 integrin (~70% reduction)
decreased platelet aggregation ( J:67798 )
• platelet aggregation was decreased by 50-60% in response to thrombin (10 nM), ADP (20 uM), collagen (20 ug/ml), and calcium ionophore A23187 (1.0 uM)
abnormal platelet dense granule physiology ( J:67798 )
• subtle differences were detected in the ATP secretion from dense granules upon thrombin and collagen activation; no differences were detected in the ADP- and calcium ionophore A23187-treated platelets




Genotype
MGI:5292738
cn2
Allelic
Composition		 Capn1tm1Ahc/Capn1tm1Ahc
Capn2tm1Tcs/Capn2tm2.1Tcs
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 B6.129-Capn2tm1Tcs/Capn2tm2.1Tcs Meox2tm1(cre)Sor Capn1tm1Ahc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capn1tm1Ahc mutation (1 available); any Capn1 mutation (33 available)
Capn2tm1Tcs mutation (1 available); any Capn2 mutation (35 available)
Capn2tm2.1Tcs mutation (1 available); any Capn2 mutation (35 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
abnormal survival ( J:175868 )
• about half survive to adulthood




Genotype
MGI:5292743
cn3
Allelic
Composition		 Capn1tm1Ahc/Capn1tm1Ahc
Capn2tm2.1Tcs/Capn2tm2.1Tcs
Tg(Tek-cre)12Flv/0
Genetic
Background		 B6.Cg-Capn2tm2.1Tcs Capn1tm1Ahc Tg(Tek-cre)12Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capn1tm1Ahc mutation (1 available); any Capn1 mutation (33 available)
Capn2tm2.1Tcs mutation (1 available); any Capn2 mutation (35 available)
Tg(Tek-cre)12Flv mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:175868 )
• viable with no significant abnormalities detected for at least 1 year




Genotype
MGI:5292739
cx4
Allelic
Composition		 Capn1tm1Ahc/Capn1tm1Ahc
Capn2tm1Tcs/Capn2tm1Tcs
Genetic
Background		 B6.129-Capn2tm1Tcs Capn1tm1Ahc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capn1tm1Ahc mutation (1 available); any Capn1 mutation (33 available)
Capn2tm1Tcs mutation (1 available); any Capn2 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
abnormal placenta labyrinth morphology ( J:175868 )
• reduced development
• apoptotic trophoblasts are detected in the labyrinthine region
pale placenta ( J:175868 )
• at E11.5

cardiovascular system
abnormal blood circulation ( J:175868 )
• blood flow in the placental labyrinth is reduced




Genotype
MGI:5292742
cx5
Allelic
Composition		 Capn1tm1Ahc/Capn1tm1Ahc
Capn2tm1Tcs/Capn2tm1Tcs
Casttm1Tcs/Casttm1Tcs
Genetic
Background		 B6.129-Capn2tm1Tcs Casttm1Tcs Capn1tm1Ahc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capn1tm1Ahc mutation (1 available); any Capn1 mutation (33 available)
Capn2tm1Tcs mutation (1 available); any Capn2 mutation (35 available)
Casttm1Tcs mutation (1 available); any Cast mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
hemorrhage ( J:175868 )
• detected in the trunk region




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory