nervous system
• dopanergic neurons in group A11 are mis-specified or lose their specificity as shown by the loss of tyrosine hydroxylase, Nkx2.1, Otx and AADC staining at E11.5 and E15.5
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Allele Symbol Allele Name Allele ID |
Otptm1Asim targeted mutation 1, Antonio Simeone MGI:2180541 |
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Summary |
3 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• dopanergic neurons in group A11 are mis-specified or lose their specificity as shown by the loss of tyrosine hydroxylase, Nkx2.1, Otx and AADC staining at E11.5 and E15.5
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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• from age 8 weeks on regular chow
(J:251771)
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• between age 6 and 12 and at 18 weeks on regular chow
(J:251771)
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• from age 8 weeks on regular chow
(J:251771)
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• between age 6 and 12 and at 18 weeks on regular chow
(J:251771)
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• from age 10 weeks on regular chow
(J:251771)
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• from age 6 weeks on regular chow
(J:251771)
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• at age 8 and 12 weeks on regular chow after 5-6h fast
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• at age 12 weeks on regular chow after 5-6h fast
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• no insulin resistance at age 12 weeks on regular chow after 5-6h fast
(J:251771)
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• at age 12 weeks on regular chow after 5-6h fast
(J:251771)
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|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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