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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Otptm1Asim
targeted mutation 1, Antonio Simeone
MGI:2180541
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Otptm1Asim/Otptm1Asim involves: 129P2/OlaHsd MGI:3713801
ht2
 		Otptm1Asim/Otp+ C3H.129P2(B6)-Otptm1Asim MGI:6402819
ht3
 		OtpM1H/Otptm1Asim involves: 129P2/OlaHsd * C3H/HeH * C57BL/6J MGI:6402821


Genotype
MGI:3713801
hm1
Allelic
Composition		 Otptm1Asim/Otptm1Asim
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otptm1Asim mutation (1 available); any Otp mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal dopaminergic neuron morphology ( J:122105 )
• dopanergic neurons in group A11 are mis-specified or lose their specificity as shown by the loss of tyrosine hydroxylase, Nkx2.1, Otx and AADC staining at E11.5 and E15.5




Genotype
MGI:6402819
ht2
Allelic
Composition		 Otptm1Asim/Otp+
Genetic
Background		 C3H.129P2(B6)-Otptm1Asim
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otptm1Asim mutation (1 available); any Otp mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue
increased body fat mass ( J:251771 , J:251771 )
• from age 8 weeks on regular chow (J:251771)
• between age 6 and 12 and at 18 weeks on regular chow (J:251771)

growth/size/body
increased body fat mass ( J:251771 , J:251771 )
• from age 8 weeks on regular chow (J:251771)
• between age 6 and 12 and at 18 weeks on regular chow (J:251771)
increased lean body mass ( J:251771 , J:251771 )
• from age 10 weeks on regular chow (J:251771)
• from age 6 weeks on regular chow (J:251771)
obese ( J:251771 )

homeostasis/metabolism
increased circulating leptin level ( J:251771 )
• at age 8 and 12 weeks on regular chow after 5-6h fast
impaired glucose tolerance ( J:251771 )
• at age 12 weeks on regular chow after 5-6h fast
insulin resistance ( J:251771 , J:251771 )
• no insulin resistance at age 12 weeks on regular chow after 5-6h fast (J:251771)
• at age 12 weeks on regular chow after 5-6h fast (J:251771)




Genotype
MGI:6402821
ht3
Allelic
Composition		 OtpM1H/Otptm1Asim
Genetic
Background		 involves: 129P2/OlaHsd * C3H/HeH * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
OtpM1H mutation (0 available); any Otp mutation (17 available)
Otptm1Asim mutation (1 available); any Otp mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/21/2024
MGI 6.24 		The Jackson Laboratory