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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cblbtm1Pngr
targeted mutation 1, Josef M Penninger
MGI:2180570
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cblbtm1Pngr/Cblbtm1Pngr B6.129P2-Cblbtm1Pngr MGI:3841992
hm2
 		Cblbtm1Pngr/Cblbtm1Pngr involves: 129 * C57BL/6 MGI:3762928
cx3
 		Cblbtm1Pngr/Cblbtm1Pngr
Itktm1Litt/Itktm1Litt 		B6.129-Itktm1Litt Cblbtm1Pngr MGI:3841993
cx4
 		Cblbtm1Pngr/Cblbtm1Pngr
Vav1tm1Tyb/Vav1tm1Tyb
Wastm1Sbs/Wastm1Sbs 		involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac MGI:3528380
cx5
 		Cblbtm1Pngr/Cblbtm1Pngr
Wastm1Sbs/Wastm1Sbs 		Not Specified MGI:3528379


Genotype
MGI:3841992
hm1
Allelic
Composition		 Cblbtm1Pngr/Cblbtm1Pngr
Genetic
Background		 B6.129P2-Cblbtm1Pngr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cblbtm1Pngr mutation (6 available); any Cblb mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell proliferation ( J:141390 )
• in response to loading with CFSE followed by stimulation with anti-CD3

hematopoietic system
increased T cell proliferation ( J:141390 )
• in response to loading with CFSE followed by stimulation with anti-CD3

cellular
increased T cell proliferation ( J:141390 )
• in response to loading with CFSE followed by stimulation with anti-CD3




Genotype
MGI:3762928
hm2
Allelic
Composition		 Cblbtm1Pngr/Cblbtm1Pngr
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cblbtm1Pngr mutation (6 available); any Cblb mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:126361 )
• greatly decreased rate of immunoglobulin receptor internalization
increased interleukin-6 secretion ( J:126361 )
• greatly enhanced levels produced by mast cells upon stimulation
increased tumor necrosis factor secretion ( J:126361 )
• greatly enhanced levels produced by mast cells upon stimulation

hematopoietic system
abnormal mast cell physiology ( J:126361 )
• greatly decreased rate of immunoglobulin receptor internalization




Genotype
MGI:3841993
cx3
Allelic
Composition		 Cblbtm1Pngr/Cblbtm1Pngr
Itktm1Litt/Itktm1Litt
Genetic
Background		 B6.129-Itktm1Litt Cblbtm1Pngr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cblbtm1Pngr mutation (6 available); any Cblb mutation (58 available)
Itktm1Litt mutation (2 available); any Itk mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:141390 )
N
• T cell proliferation in response to loading with CFSE followed by stimulation with anti-CD3 is similar to controls, unlike in either single null mouse
abnormal T cell morphology ( J:141390 )
• similar to mice homozygous null for Itk alone, most T cells have an activated/memory like phenotype
abnormal T-helper 2 cell differentiation ( J:141390 )
• partial rescue of defect in Th2 polarization compared to mice homozygous null for Itk alone
decreased T cell number ( J:141390 )
• decrease in T cell numbers similar to that in mice homozygous null for Itk alone
decreased interleukin-2 secretion ( J:141390 )
• partial rescue of decreased IL2 secretion in response to anti-CD3 anti-CD28 costimulation compared to mice homozygous null for Itk alone

hematopoietic system
abnormal T cell morphology ( J:141390 )
• similar to mice homozygous null for Itk alone, most T cells have an activated/memory like phenotype
abnormal T-helper 2 cell differentiation ( J:141390 )
• partial rescue of defect in Th2 polarization compared to mice homozygous null for Itk alone
decreased T cell number ( J:141390 )
• decrease in T cell numbers similar to that in mice homozygous null for Itk alone




Genotype
MGI:3528380
cx4
Allelic
Composition		 Cblbtm1Pngr/Cblbtm1Pngr
Vav1tm1Tyb/Vav1tm1Tyb
Wastm1Sbs/Wastm1Sbs
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cblbtm1Pngr mutation (6 available); any Cblb mutation (58 available)
Vav1tm1Tyb mutation (2 available); any Vav1 mutation (60 available)
Wastm1Sbs mutation (2 available); any Was mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell physiology ( J:79550 )
• introduction of the Cblbtm1Pngr mutation into a Wastm1Sbs/Vav1tm1Tyb double null background fails to restore T cell responses and receptor clustering, indicating that WAS protein is critical for deregulated proliferation and membrane receptor reorganization of Cblbtm1Pngr mutant T cells

hematopoietic system
abnormal T cell physiology ( J:79550 )
• introduction of the Cblbtm1Pngr mutation into a Wastm1Sbs/Vav1tm1Tyb double null background fails to restore T cell responses and receptor clustering, indicating that WAS protein is critical for deregulated proliferation and membrane receptor reorganization of Cblbtm1Pngr mutant T cells




Genotype
MGI:3528379
cx5
Allelic
Composition		 Cblbtm1Pngr/Cblbtm1Pngr
Wastm1Sbs/Wastm1Sbs
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cblbtm1Pngr mutation (6 available); any Cblb mutation (58 available)
Wastm1Sbs mutation (2 available); any Was mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell physiology ( J:79550 )
• introduction of the Cblbtm1Pngr mutation into a Wastm1Sbs null background fails to restore T cell responses and receptor clustering, indicating that WAS protein is critical for deregulated proliferation and membrane receptor reorganization of Cblbtm1Pngr mutant T cells

hematopoietic system
abnormal T cell physiology ( J:79550 )
• introduction of the Cblbtm1Pngr mutation into a Wastm1Sbs null background fails to restore T cell responses and receptor clustering, indicating that WAS protein is critical for deregulated proliferation and membrane receptor reorganization of Cblbtm1Pngr mutant T cells




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11/12/2024
MGI 6.24 		The Jackson Laboratory