About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cblbtm1Hua
targeted mutation 1, Hua Gu
MGI:2180572
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cblbtm1Hua/Cblbtm1Hua B6.129P2-Cblbtm1Hua MGI:3525206
hm2
 		Cblbtm1Hua/Cblbtm1Hua Not Specified MGI:3052006
cn3
 		Cbltm2Hua/Cbltm2Hua
Cblbtm1Hua/Cblbtm1Hua
Tg(Lck-cre)I57Jxm/0 		involves: 129P2/OlaHsd * C57BL/6 * ICR MGI:2652089
cx4
 		Cblbtm1Hua/Cblbtm1Hua
Ubash3btm1Jni/Ubash3btm1Jni
Ubash3atm1Jni/Ubash3atm1Jni 		Not Specified MGI:3052005


Genotype
MGI:3525206
hm1
Allelic
Composition		 Cblbtm1Hua/Cblbtm1Hua
Genetic
Background		 B6.129P2-Cblbtm1Hua
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cblbtm1Hua mutation (0 available); any Cblb mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell proliferation ( J:94685 )
• mutant T cells are hypersensitive to anti-CD3 stimulated proliferation
• this increase is more pronounced than in B6.129X1-Stk17btm1Hed homozygotes
increased interleukin-2 secretion ( J:94685 )
• more IL-2 is produced by nave T cells in response to anti-CD3 stimulation
• this increase is more pronounced than in B6.129X1-Stk17btm1Hed homozygotes
increased susceptibility to experimental autoimmune encephalomyelitis ( J:94685 )
• both the incidence and severity of experimental autoimmune encephalomyelitis are increased in mutants

hematopoietic system
increased T cell proliferation ( J:94685 )
• mutant T cells are hypersensitive to anti-CD3 stimulated proliferation
• this increase is more pronounced than in B6.129X1-Stk17btm1Hed homozygotes

cellular
increased T cell proliferation ( J:94685 )
• mutant T cells are hypersensitive to anti-CD3 stimulated proliferation
• this increase is more pronounced than in B6.129X1-Stk17btm1Hed homozygotes




Genotype
MGI:3052006
hm2
Allelic
Composition		 Cblbtm1Hua/Cblbtm1Hua
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cblbtm1Hua mutation (0 available); any Cblb mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell proliferation ( J:89761 )
• single positive T cell proliferation is increased in response to antigen
• this increase is less pronounced than in Elf1tm1Jni and Ubash3atm1Jni double homozygotes

hematopoietic system
increased T cell proliferation ( J:89761 )
• single positive T cell proliferation is increased in response to antigen
• this increase is less pronounced than in Elf1tm1Jni and Ubash3atm1Jni double homozygotes

cellular
increased T cell proliferation ( J:89761 )
• single positive T cell proliferation is increased in response to antigen
• this increase is less pronounced than in Elf1tm1Jni and Ubash3atm1Jni double homozygotes




Genotype
MGI:2652089
cn3
Allelic
Composition		 Cbltm2Hua/Cbltm2Hua
Cblbtm1Hua/Cblbtm1Hua
Tg(Lck-cre)I57Jxm/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cblbtm1Hua mutation (0 available); any Cblb mutation (56 available)
Cbltm2Hua mutation (0 available); any Cbl mutation (57 available)
Tg(Lck-cre)I57Jxm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:80427 )
• female animals were moribund at 12 weeks of age; male animals were moribund at 16 weeks of age

cardiovascular system
abnormal blood vessel morphology ( J:80427 )
• thickened intima, thickened tunica aventitia and severe T cell infilatration

growth/size/body
decreased body weight ( J:80427 )
• weight gain lagged behind wild-type controls after 3 weeks of age
enlarged spleen ( J:80427 )

hematopoietic system
increased T cell proliferation ( J:80427 )
• in response to anti-CD3 stimulation
abnormal T cell morphology ( J:80427 )
• enlarged T cells

immune system
abnormal T cell morphology ( J:80427 )
• enlarged T cells
increased T cell proliferation ( J:80427 )
• in response to anti-CD3 stimulation
dermatitis ( J:80427 )
• subacute dermatitis

liver/biliary system

integument
dermatitis ( J:80427 )
• subacute dermatitis

cellular
increased T cell proliferation ( J:80427 )
• in response to anti-CD3 stimulation




Genotype
MGI:3052005
cx4
Allelic
Composition		 Cblbtm1Hua/Cblbtm1Hua
Ubash3btm1Jni/Ubash3btm1Jni
Ubash3atm1Jni/Ubash3atm1Jni
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cblbtm1Hua mutation (0 available); any Cblb mutation (56 available)
Ubash3atm1Jni mutation (0 available); any Ubash3a mutation (32 available)
Ubash3btm1Jni mutation (0 available); any Ubash3b mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell proliferation ( J:89761 )
• single positive T cell proliferation is synergistically increased in response to antigen compared to either Elf1tm1Jni Ubash3atm1Jni double homozygotes or Cblbtm1Hua homozygotes
increased susceptibility to experimental autoimmune encephalomyelitis ( J:89761 )
• the incidence and severity of experimental autoimmune encephalomyelitis is increased similar to the increase seen in Elf1tm1Jni Ubash3atm1Jni double homozygotes

hematopoietic system
increased T cell proliferation ( J:89761 )
• single positive T cell proliferation is synergistically increased in response to antigen compared to either Elf1tm1Jni Ubash3atm1Jni double homozygotes or Cblbtm1Hua homozygotes

cellular
increased T cell proliferation ( J:89761 )
• single positive T cell proliferation is synergistically increased in response to antigen compared to either Elf1tm1Jni Ubash3atm1Jni double homozygotes or Cblbtm1Hua homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory