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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cblbtm1Hua
targeted mutation 1, Hua Gu
MGI:2180572
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cblbtm1Hua/Cblbtm1Hua B6.129P2-Cblbtm1Hua MGI:3525206
hm2
 		Cblbtm1Hua/Cblbtm1Hua Not Specified MGI:3052006
cn3
 		Cbltm2Hua/Cbltm2Hua
Cblbtm1Hua/Cblbtm1Hua
Tg(Lck-cre)I57Jxm/0 		involves: 129P2/OlaHsd * C57BL/6 * ICR MGI:2652089
cx4
 		Cblbtm1Hua/Cblbtm1Hua
Ubash3btm1Jni/Ubash3btm1Jni
Ubash3atm1Jni/Ubash3atm1Jni 		Not Specified MGI:3052005


Genotype
MGI:3525206
hm1
Allelic
Composition		 Cblbtm1Hua/Cblbtm1Hua
Genetic
Background		 B6.129P2-Cblbtm1Hua
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cblbtm1Hua mutation (0 available); any Cblb mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell proliferation ( J:94685 )
• mutant T cells are hypersensitive to anti-CD3 stimulated proliferation
• this increase is more pronounced than in B6.129X1-Stk17btm1Hed homozygotes
increased interleukin-2 secretion ( J:94685 )
• more IL-2 is produced by nave T cells in response to anti-CD3 stimulation
• this increase is more pronounced than in B6.129X1-Stk17btm1Hed homozygotes
increased susceptibility to experimental autoimmune encephalomyelitis ( J:94685 )
• both the incidence and severity of experimental autoimmune encephalomyelitis are increased in mutants

hematopoietic system
increased T cell proliferation ( J:94685 )
• mutant T cells are hypersensitive to anti-CD3 stimulated proliferation
• this increase is more pronounced than in B6.129X1-Stk17btm1Hed homozygotes

cellular
increased T cell proliferation ( J:94685 )
• mutant T cells are hypersensitive to anti-CD3 stimulated proliferation
• this increase is more pronounced than in B6.129X1-Stk17btm1Hed homozygotes




Genotype
MGI:3052006
hm2
Allelic
Composition		 Cblbtm1Hua/Cblbtm1Hua
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cblbtm1Hua mutation (0 available); any Cblb mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell proliferation ( J:89761 )
• single positive T cell proliferation is increased in response to antigen
• this increase is less pronounced than in Elf1tm1Jni and Ubash3atm1Jni double homozygotes

hematopoietic system
increased T cell proliferation ( J:89761 )
• single positive T cell proliferation is increased in response to antigen
• this increase is less pronounced than in Elf1tm1Jni and Ubash3atm1Jni double homozygotes

cellular
increased T cell proliferation ( J:89761 )
• single positive T cell proliferation is increased in response to antigen
• this increase is less pronounced than in Elf1tm1Jni and Ubash3atm1Jni double homozygotes




Genotype
MGI:2652089
cn3
Allelic
Composition		 Cbltm2Hua/Cbltm2Hua
Cblbtm1Hua/Cblbtm1Hua
Tg(Lck-cre)I57Jxm/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cblbtm1Hua mutation (0 available); any Cblb mutation (58 available)
Cbltm2Hua mutation (0 available); any Cbl mutation (59 available)
Tg(Lck-cre)I57Jxm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:80427 )
• female animals were moribund at 12 weeks of age; male animals were moribund at 16 weeks of age

cardiovascular system
abnormal blood vessel morphology ( J:80427 )
• thickened intima, thickened tunica aventitia and severe T cell infilatration

growth/size/body
decreased body weight ( J:80427 )
• weight gain lagged behind wild-type controls after 3 weeks of age
enlarged spleen ( J:80427 )

hematopoietic system
increased T cell proliferation ( J:80427 )
• in response to anti-CD3 stimulation
abnormal T cell morphology ( J:80427 )
• enlarged T cells

immune system
abnormal T cell morphology ( J:80427 )
• enlarged T cells
increased T cell proliferation ( J:80427 )
• in response to anti-CD3 stimulation
dermatitis ( J:80427 )
• subacute dermatitis

liver/biliary system

integument
dermatitis ( J:80427 )
• subacute dermatitis

cellular
increased T cell proliferation ( J:80427 )
• in response to anti-CD3 stimulation




Genotype
MGI:3052005
cx4
Allelic
Composition		 Cblbtm1Hua/Cblbtm1Hua
Ubash3btm1Jni/Ubash3btm1Jni
Ubash3atm1Jni/Ubash3atm1Jni
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cblbtm1Hua mutation (0 available); any Cblb mutation (58 available)
Ubash3atm1Jni mutation (0 available); any Ubash3a mutation (33 available)
Ubash3btm1Jni mutation (0 available); any Ubash3b mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell proliferation ( J:89761 )
• single positive T cell proliferation is synergistically increased in response to antigen compared to either Elf1tm1Jni Ubash3atm1Jni double homozygotes or Cblbtm1Hua homozygotes
increased susceptibility to experimental autoimmune encephalomyelitis ( J:89761 )
• the incidence and severity of experimental autoimmune encephalomyelitis is increased similar to the increase seen in Elf1tm1Jni Ubash3atm1Jni double homozygotes

hematopoietic system
increased T cell proliferation ( J:89761 )
• single positive T cell proliferation is synergistically increased in response to antigen compared to either Elf1tm1Jni Ubash3atm1Jni double homozygotes or Cblbtm1Hua homozygotes

cellular
increased T cell proliferation ( J:89761 )
• single positive T cell proliferation is synergistically increased in response to antigen compared to either Elf1tm1Jni Ubash3atm1Jni double homozygotes or Cblbtm1Hua homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory