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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cbltm1.1Hua
targeted mutation 1.1, Hua Gu
MGI:2180576
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Cbltm1.1Hua/Cbltm1.1Hua
Lattm1Les/Lattm1Les 		involves: 129P2/OlaHsd MGI:3626257
cx2
 		Cbltm1.1Hua/Cbltm1.1Hua
Lcp2tm1Gak/Lcp2tm1Gak
Rag2tm1Fwa/Rag2tm1Fwa 		involves: 129P2/OlaHsd * 129S/SvEv * 129S1/Sv * 129X1/SvJ MGI:3626254
cx3
 		Cbltm1.1Hua/Cbltm1.1Hua
Lcp2tm1Gak/Lcp2tm1Gak 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:3626255


Genotype
MGI:3626257
cx1
Allelic
Composition		 Cbltm1.1Hua/Cbltm1.1Hua
Lattm1Les/Lattm1Les
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbltm1.1Hua mutation (0 available); any Cbl mutation (59 available)
Lattm1Les mutation (0 available); any Lat mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal thymus development ( J:91369 )
• Cbl inactivation in Lat deficient mice partially rescues thymic development; ~24% double positive and and 7% CD4 single positive cells are detected in the thymi of double mutants but not in Lat-null animals
thymus hypoplasia ( J:91369 )
• thymus cellularity of double knockout mice is 5% that of wild-type
increased CD4-positive, alpha-beta T cell number ( J:91369 )
• mutants have elevated levels of CD4+ T cells in the spleen and lymph nodes of 6 week old mice compared to wild-type or Cbl-null mice

immune system
abnormal thymus development ( J:91369 )
• Cbl inactivation in Lat deficient mice partially rescues thymic development; ~24% double positive and and 7% CD4 single positive cells are detected in the thymi of double mutants but not in Lat-null animals
thymus hypoplasia ( J:91369 )
• thymus cellularity of double knockout mice is 5% that of wild-type
increased CD4-positive, alpha-beta T cell number ( J:91369 )
• mutants have elevated levels of CD4+ T cells in the spleen and lymph nodes of 6 week old mice compared to wild-type or Cbl-null mice
liver inflammation ( J:91369 )
• similar to what is seen in Lcp Cbl double null mice
lung inflammation ( J:91369 )
• similar to what is seen in Lcp Cbl double null mice

liver/biliary system
liver inflammation ( J:91369 )
• similar to what is seen in Lcp Cbl double null mice

respiratory system
lung inflammation ( J:91369 )
• similar to what is seen in Lcp Cbl double null mice

endocrine/exocrine glands
abnormal thymus development ( J:91369 )
• Cbl inactivation in Lat deficient mice partially rescues thymic development; ~24% double positive and and 7% CD4 single positive cells are detected in the thymi of double mutants but not in Lat-null animals
thymus hypoplasia ( J:91369 )
• thymus cellularity of double knockout mice is 5% that of wild-type




Genotype
MGI:3626254
cx2
Allelic
Composition		 Cbltm1.1Hua/Cbltm1.1Hua
Lcp2tm1Gak/Lcp2tm1Gak
Rag2tm1Fwa/Rag2tm1Fwa
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbltm1.1Hua mutation (0 available); any Cbl mutation (59 available)
Lcp2tm1Gak mutation (1 available); any Lcp2 mutation (41 available)
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (121 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell differentiation ( J:91369 )
• no double positive or single positive T cells are detected in triple mutants

immune system
abnormal T cell differentiation ( J:91369 )
• no double positive or single positive T cells are detected in triple mutants




Genotype
MGI:3626255
cx3
Allelic
Composition		 Cbltm1.1Hua/Cbltm1.1Hua
Lcp2tm1Gak/Lcp2tm1Gak
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbltm1.1Hua mutation (0 available); any Cbl mutation (59 available)
Lcp2tm1Gak mutation (1 available); any Lcp2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
enlarged spleen ( J:91369 )
• mice develop progressive splenomegaly with age and die at ~6 months of age: mutants have 8-12 times the number of splenic CD4+ cells compared to wild-type
abnormal T cell differentiation ( J:91369 )
• double knockouts generate significant proportions of double positive and Cd4+CD8- T cells compared to Lcp knockouts; these populations are significantly lower than those expected in wild-type or Cbl-null mice
• expression of CD3 or Tcrb is decreased on thymic CD4+CD8- cells compared to wild-type cells; expression of CD4 and CD69 is increased on double positive and single positive CD4 thymocytes relative to wild-type
increased CD4-positive, alpha-beta T cell number ( J:91369 )
• mutants have elevated levels of CD4+ T cells in the spleen and lymph nodes of 6 week old mice compared to wild-type or Cbl-null mice; numbers are ~10x the number observed in wild-type or Cbl-null mice at 24 weeks of age
abnormal cytokine secretion ( J:91369 )
• many more CD4+ cells produce Il-2, Il-4 and Ifng compared to wild-type
liver inflammation ( J:91369 )
• extensive lymphocyte infiltration is observed in the liver of mutants; lymphocytes are observed as clusters around hepatic parenchyma
lung inflammation ( J:91369 )
• extensive lymphocyte infiltration is observed in the lungs of mutants; lymphocytes are observed as clusters around pulmonary vessels and bronchioles

hematopoietic system
enlarged spleen ( J:91369 )
• mice develop progressive splenomegaly with age and die at ~6 months of age: mutants have 8-12 times the number of splenic CD4+ cells compared to wild-type
abnormal T cell differentiation ( J:91369 )
• double knockouts generate significant proportions of double positive and Cd4+CD8- T cells compared to Lcp knockouts; these populations are significantly lower than those expected in wild-type or Cbl-null mice
• expression of CD3 or Tcrb is decreased on thymic CD4+CD8- cells compared to wild-type cells; expression of CD4 and CD69 is increased on double positive and single positive CD4 thymocytes relative to wild-type
increased CD4-positive, alpha-beta T cell number ( J:91369 )
• mutants have elevated levels of CD4+ T cells in the spleen and lymph nodes of 6 week old mice compared to wild-type or Cbl-null mice; numbers are ~10x the number observed in wild-type or Cbl-null mice at 24 weeks of age

liver/biliary system
liver inflammation ( J:91369 )
• extensive lymphocyte infiltration is observed in the liver of mutants; lymphocytes are observed as clusters around hepatic parenchyma

respiratory system
lung inflammation ( J:91369 )
• extensive lymphocyte infiltration is observed in the lungs of mutants; lymphocytes are observed as clusters around pulmonary vessels and bronchioles

growth/size/body
enlarged spleen ( J:91369 )
• mice develop progressive splenomegaly with age and die at ~6 months of age: mutants have 8-12 times the number of splenic CD4+ cells compared to wild-type




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory