Phenotypes associated with this allele

• Allele Symbol: Cckbr^tm1Kpn
• Allele Name: targeted mutation 1, Alan S Kopin
• Allele ID: MGI:2180591
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cckbr^tm1Kpn/Cckbr^tm1Kpn	involves: 129S2/SvPas	MGI:3789842

Genotype
MGI:3789842

hm1

• Allelic Composition: Cckbr^tm1Kpn/Cckbr^tm1Kpn
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal gastric gland morphology ( J:49320 )

• there is a 51% decrease in ECL cells found in the stomach

• there is an increased number of H+, K+, ATPase ? cells that may represent a population of developmentally arrested epithelial cells

abnormal stomach enteroendocrine cell morphology ( J:49320 )

• there is a 43% decrease in the number of somatostatin-producing "D" cells in the stomach and a 53% increase in the number of gastrin-producing "G" cells

• the G/D cell ratio is increased by 198%

abnormal gastric parietal cell morphology ( J:49320 )

• there are 32% less parietal cells per gland than is found in wild-type mice

• the distribution of these parietal cells is irregular

increased stomach pH ( J:49320 )

• the mean fasting stomach pH of mice is 5.2, which is a 63% higher than in age- and sex- matched controls

homeostasis/metabolism

increased circulating gastrin level ( J:49320 )

• the mean circulating gastrin level is 612 pmol/L, which is 937% higher than in wild-type mice

endocrine/exocrine glands

abnormal gastric gland morphology ( J:49320 )

• there is a 51% decrease in ECL cells found in the stomach

• there is an increased number of H+, K+, ATPase ? cells that may represent a population of developmentally arrested epithelial cells

abnormal stomach enteroendocrine cell morphology ( J:49320 )

• there is a 43% decrease in the number of somatostatin-producing "D" cells in the stomach and a 53% increase in the number of gastrin-producing "G" cells

• the G/D cell ratio is increased by 198%

abnormal gastric parietal cell morphology ( J:49320 )

• there are 32% less parietal cells per gland than is found in wild-type mice

• the distribution of these parietal cells is irregular

abnormal pancreatic delta cell morphology ( J:49320 )