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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccna1tm1Djw
targeted mutation 1, Debra J Wolgemuth
MGI:2180633
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccna1tm1Djw/Ccna1tm1Djw involves: 129S7/SvEvBrd MGI:2657243
cn2
 		Ccna1tm1Djw/Ccna1tm1Djw
Ccna2tm1.1Pisc/Ccna2tm1.2Pisc 		involves: 129S4/SvJaeSor * 129S7/SvEvBrd MGI:4461990
cn3
 		Ccna1tm1Djw/Ccna1tm1Djw
Ccna2tm1.1Pisc/Ccna2tm1.1Pisc 		involves: 129S7/SvEvBrd MGI:4461988
cn4
 		Ccna1tm1Djw/Ccna1tm1Djw
Ccna2tm1.1Pisc/Ccna2tm1.1Pisc
Tg(Mx1-cre)1Cgn/0 		involves: 129S7/SvEvBrd * C57BL/6 * CBA MGI:4461991


Genotype
MGI:2657243
hm1
Allelic
Composition		 Ccna1tm1Djw/Ccna1tm1Djw
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccna1tm1Djw mutation (0 available); any Ccna1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
increased male germ cell apoptosis ( J:51290 )
• increased germ cell apoptosis
• absence of post-meiotic cells in the seminiferous tubules
decreased testis weight ( J:51290 )
• testicular weight is 61% that of wild-type littermates at 6 weeks of age
arrest of spermatogenesis ( J:51290 )
• block in spermatogenesis before the first meiotic division
arrest of male meiosis ( J:51290 )
• complete disruption of gametogenesis
• arrest during late prophase of meiosis I
• normal spermatogonia and early spermatocytes
• degeneration of late spermatocytes, nuclear condensation and formation of syncytial multinucleated cells

endocrine/exocrine glands
decreased testis weight ( J:51290 )
• testicular weight is 61% that of wild-type littermates at 6 weeks of age

cellular
arrest of male meiosis ( J:51290 )
• complete disruption of gametogenesis
• arrest during late prophase of meiosis I
• normal spermatogonia and early spermatocytes
• degeneration of late spermatocytes, nuclear condensation and formation of syncytial multinucleated cells
increased male germ cell apoptosis ( J:51290 )
• increased germ cell apoptosis
• absence of post-meiotic cells in the seminiferous tubules




Genotype
MGI:4461990
cn2
Allelic
Composition		 Ccna1tm1Djw/Ccna1tm1Djw
Ccna2tm1.1Pisc/Ccna2tm1.2Pisc
Genetic
Background		 involves: 129S4/SvJaeSor * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccna1tm1Djw mutation (0 available); any Ccna1 mutation (28 available)
Ccna2tm1.1Pisc mutation (0 available); any Ccna2 mutation (15 available)
Ccna2tm1.2Pisc mutation (0 available); any Ccna2 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased cell proliferation ( J:155178 )
• cre-transduced embryonic stem cells fail to proliferate unlike similarly treated double heterozygous cells




Genotype
MGI:4461988
cn3
Allelic
Composition		 Ccna1tm1Djw/Ccna1tm1Djw
Ccna2tm1.1Pisc/Ccna2tm1.1Pisc
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccna1tm1Djw mutation (0 available); any Ccna1 mutation (28 available)
Ccna2tm1.1Pisc mutation (0 available); any Ccna2 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal definitive hematopoiesis ( J:155178 )
• hematopoietic stem cells transduced with cre fail to proliferate and fail to form colonies unlike similarly treated double heterozygous cells
abnormal hematopoietic system physiology ( J:155178 )
• hematopoietic stem cells transduced with cre fail to proliferate and fail to form colonies unlike similarly treated double heterozygous cells

cellular
abnormal cell cycle ( J:155178 )
• fibroblast cells treated with cre-expressing retroviruses exhibit an increase in the fraction o cells in the S and G2/M phase with a decrease in the G1 phase population compared with cells from wild-type mice
decreased cell proliferation ( J:155178 )
• cre-transduced embryonic stem cells fail to proliferate unlike similarly treated double heterozygous cells




Genotype
MGI:4461991
cn4
Allelic
Composition		 Ccna1tm1Djw/Ccna1tm1Djw
Ccna2tm1.1Pisc/Ccna2tm1.1Pisc
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccna1tm1Djw mutation (0 available); any Ccna1 mutation (28 available)
Ccna2tm1.1Pisc mutation (0 available); any Ccna2 mutation (15 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:155178 )
• pIpC-treated mice die within 30 days

hematopoietic system
decreased common myeloid progenitor cell number ( J:155178 )
• in pIpC-treated mice (including CFU-G, CFU-M, CFU-GM, and CFU-GEMM)
anemia ( J:155178 )
• severe in pIpC-treated mice
decreased bone marrow cell number ( J:155178 )
• in pIpC-treated mice
decreased erythrocyte cell number ( J:155178 )
• in pIpC-treated mice
thrombocytopenia ( J:155178 )
• in pIpC-treated mice
decreased leukocyte cell number ( J:155178 )
• in pIpC-treated mice
decreased hematopoietic stem cell number ( J:155178 )
• pIpC-treated mice exhibit a reduction of common myeloid progenitors (CMP), granulocyte-macrophage progenitors (GMP), and megakaryocyte-erythroid progenitors (MEP) compared with similarly treated control mice

immune system
decreased leukocyte cell number ( J:155178 )
• in pIpC-treated mice




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11/12/2024
MGI 6.24 		The Jackson Laboratory