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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ctla4tm1All
targeted mutation 1, James P Allison
MGI:2180670
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ctla4tm1All/Ctla4tm1All involves: 129S1/Sv * 129X1/SvJ MGI:3618343
hm2
 		Ctla4tm1All/Ctla4tm1All involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4940118
hm3
 		Ctla4tm1All/Ctla4tm1All involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * NOD MGI:4940107
cx4
 		Ctla4tm1All/Ctla4tm1All
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraTcrb)8Rest/0 		involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 MGI:4940117
cx5
 		Ctla4tm1All/Ctla4tm1All
Tg(TcraTcrb)8Rest/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4940116
cx6
 		Ctla4tm1All/Ctla4tm1All
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * NOD * SJL MGI:4940108
cx7
 		Ctla4tm1All/Ctla4tm1All
Tg(TcrAND)53Hed/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:4940114
cx8
 		Ctla4tm1All/Ctla4tm1All
Rag1tm1Mom/Rag1tm1Mom
Tg(TcrAND)53Hed/0 		involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:4940115


Genotype
MGI:3618343
hm1
Allelic
Composition		 Ctla4tm1All/Ctla4tm1All
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctla4tm1All mutation (2 available); any Ctla4 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:42481 )
• homozygous mice die at 3 to 4 weeks of age

immune system
abnormal thymus morphology ( J:42481 )
• in mutants older than 12 days of age, thymi appear to have altered morphology
increased double-negative T cell number ( J:42481 )
• there is an increase in the number of double negative thymocytes
decreased T cell number ( J:42481 )
• there is a decrease in the number of single positive thymocytes
decreased double-positive T cell number ( J:42481 )
• there is a decrease in the number of single positive thymocytes
lymph node hypoplasia ( J:42481 )
• in visibly ill mice, decreased thymic cellularity is observed

hematopoietic system
abnormal thymus morphology ( J:42481 )
• in mutants older than 12 days of age, thymi appear to have altered morphology
increased double-negative T cell number ( J:42481 )
• there is an increase in the number of double negative thymocytes
decreased T cell number ( J:42481 )
• there is a decrease in the number of single positive thymocytes
decreased double-positive T cell number ( J:42481 )
• there is a decrease in the number of single positive thymocytes

endocrine/exocrine glands
abnormal thymus morphology ( J:42481 )
• in mutants older than 12 days of age, thymi appear to have altered morphology




Genotype
MGI:4940118
hm2
Allelic
Composition		 Ctla4tm1All/Ctla4tm1All
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctla4tm1All mutation (2 available); any Ctla4 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
variable depigmentation ( J:140448 )
• 1 in 6 mice develop autoimmune vitiligo

pigmentation
variable depigmentation ( J:140448 )
• 1 in 6 mice develop autoimmune vitiligo




Genotype
MGI:4940107
hm3
Allelic
Composition		 Ctla4tm1All/Ctla4tm1All
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctla4tm1All mutation (2 available); any Ctla4 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:109887 )
• mice die at 3 to 4 weeks of age

immune system
increased acute inflammation ( J:109887 )
• at 3 weeks, mice exhibit extensive infiltration of the heart, liver, and pancreas unlike in wild-type mice




Genotype
MGI:4940117
cx4
Allelic
Composition		 Ctla4tm1All/Ctla4tm1All
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraTcrb)8Rest/0
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctla4tm1All mutation (2 available); any Ctla4 mutation (54 available)
Rag1tm1Mom mutation (49 available); any Rag1 mutation (123 available)
Tg(TcraTcrb)8Rest mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:140448 )
N
• mice exhibit a normal lifespan

immune system
immune system phenotype ( J:140448 )
N
• CD8+ T cells exhibit a completely naive phenotype

pigmentation
pigmentation phenotype ( J:140448 )
N
• mice do not develop autoimmune vitiligo




Genotype
MGI:4940116
cx5
Allelic
Composition		 Ctla4tm1All/Ctla4tm1All
Tg(TcraTcrb)8Rest/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctla4tm1All mutation (2 available); any Ctla4 mutation (54 available)
Tg(TcraTcrb)8Rest mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:140448 )
• mice die at 10 to 12 weeks

immune system
increased interferon-gamma secretion ( J:140448 )
• hgp100(25-33)-treated splenocyte exhibit increased IFN-gamma secretion compared with splenocytes from Tg(TcraTcrb)8Rest mice

pigmentation
variable depigmentation ( J:140448 )
• at 4 to 6 weeks, 48 of 49 mice develop autoimmune vitiligo unlike Tg(TcraTcrb)8Rest mice

hematopoietic system

integument
variable depigmentation ( J:140448 )
• at 4 to 6 weeks, 48 of 49 mice develop autoimmune vitiligo unlike Tg(TcraTcrb)8Rest mice




Genotype
MGI:4940108
cx6
Allelic
Composition		 Ctla4tm1All/Ctla4tm1All
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * NOD * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctla4tm1All mutation (2 available); any Ctla4 mutation (54 available)
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:109887 )
N
• mice survive beyond 3 to 4 weeks of age unlike Ctla4tm1All homozygotes

immune system
insulitis ( J:109887 )
• splenocytes transferred into Tcratm1Mjo/Tcratm1Mjo Tg(TcraBDC2.5,TcrbBDC2.5)1Doi induce diabetes at a higher rate than when Ctla4tm1All/Ctla4+ Tg(TcraBDC2.5,TcrbBDC2.5)1Doi splenocytes are used
abnormal splenocyte physiology ( J:109887 )
• splenocytes transferred into Tcratm1Mjo/Tcratm1Mjo Tg(TcraBDC2.5,TcrbBDC2.5)1Doi induce diabetes at a higher rate than when Ctla4tm1All/Ctla4+ Tg(TcraBDC2.5,TcrbBDC2.5)1Doi splenocytes are used
increased acute inflammation ( J:109887 )
• at 6 weeks, mice exhibit infiltration in the pancreas and spleen unlike in wild-type mice
• however, infiltration is not as severe or extensive as in Ctla4tm1All homozygotes

hematopoietic system
abnormal splenocyte physiology ( J:109887 )
• splenocytes transferred into Tcratm1Mjo/Tcratm1Mjo Tg(TcraBDC2.5,TcrbBDC2.5)1Doi induce diabetes at a higher rate than when Ctla4tm1All/Ctla4+ Tg(TcraBDC2.5,TcrbBDC2.5)1Doi splenocytes are used

endocrine/exocrine glands
insulitis ( J:109887 )
• splenocytes transferred into Tcratm1Mjo/Tcratm1Mjo Tg(TcraBDC2.5,TcrbBDC2.5)1Doi induce diabetes at a higher rate than when Ctla4tm1All/Ctla4+ Tg(TcraBDC2.5,TcrbBDC2.5)1Doi splenocytes are used

growth/size/body
enlarged spleen ( J:109887 )




Genotype
MGI:4940114
cx7
Allelic
Composition		 Ctla4tm1All/Ctla4tm1All
Tg(TcrAND)53Hed/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctla4tm1All mutation (2 available); any Ctla4 mutation (54 available)
Tg(TcrAND)53Hed mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:119845 )
• mice die at 8 to 12 weeks of age

immune system
abnormal lymphopoiesis ( J:119845 )
• onset of lymphoproliferation is delayed compared to in Ctla4tm1All homozygotes
abnormal T cell subpopulation ratio ( J:119845 )
• mice exhibit the expected skewing toward CD4+ T cells as in Tg(TcrAND)53Hed compared with wild-type mice
increased CD8-positive, alpha-beta T cell number ( J:119845 )
• in absolute numbers compared with Tg(TcrAND)53Hed mice
abnormal T cell activation ( J:119845 )
• at 4 weeks, nearly all CD4+ T cells exhibit an activated phenotype unlike in Tg(TcrAND)53Hed mice

hematopoietic system
abnormal lymphopoiesis ( J:119845 )
• onset of lymphoproliferation is delayed compared to in Ctla4tm1All homozygotes
abnormal T cell subpopulation ratio ( J:119845 )
• mice exhibit the expected skewing toward CD4+ T cells as in Tg(TcrAND)53Hed compared with wild-type mice
increased CD8-positive, alpha-beta T cell number ( J:119845 )
• in absolute numbers compared with Tg(TcrAND)53Hed mice
abnormal T cell activation ( J:119845 )
• at 4 weeks, nearly all CD4+ T cells exhibit an activated phenotype unlike in Tg(TcrAND)53Hed mice




Genotype
MGI:4940115
cx8
Allelic
Composition		 Ctla4tm1All/Ctla4tm1All
Rag1tm1Mom/Rag1tm1Mom
Tg(TcrAND)53Hed/0
Genetic
Background		 involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctla4tm1All mutation (2 available); any Ctla4 mutation (54 available)
Rag1tm1Mom mutation (49 available); any Rag1 mutation (123 available)
Tg(TcrAND)53Hed mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell activation ( J:119845 )
• nearly all CD4+ T cells in aged mice exhibit an activated phenotype unlike in Tg(TcrAND)53Hed mice
• however, lymph node T cells maintain a naive phenotype in young mice
increased T cell proliferation ( J:119845 )
• CD4+ T cells exhibit increased primary and secondary antigen-specific proliferative responses compared to in Rag1tm1Mom/Rag1tm1Mom Tg(TcrAND)53Hed mice
increased interleukin-4 secretion ( J:119845 )
• in response to primary and secondary pigeon cytochrome c stimulation, the frequency of IL4-secreting T cells is increased compared to in Rag1tm1Mom/Rag1tm1Mom Tg(TcrAND)53Hed mice

hematopoietic system
abnormal T cell activation ( J:119845 )
• nearly all CD4+ T cells in aged mice exhibit an activated phenotype unlike in Tg(TcrAND)53Hed mice
• however, lymph node T cells maintain a naive phenotype in young mice
increased T cell proliferation ( J:119845 )
• CD4+ T cells exhibit increased primary and secondary antigen-specific proliferative responses compared to in Rag1tm1Mom/Rag1tm1Mom Tg(TcrAND)53Hed mice

cellular
increased T cell proliferation ( J:119845 )
• CD4+ T cells exhibit increased primary and secondary antigen-specific proliferative responses compared to in Rag1tm1Mom/Rag1tm1Mom Tg(TcrAND)53Hed mice




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory