All Phenotypes Cd22<tm1Eac> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd22^tm1Eac/Cd22^tm1Eac	involves: 129P2/OlaHsd * C57BL/6	MGI:3852060
cx2	Cd22^tm1Eac/Cd22⁺ Tg(IghelMD4)4Ccg/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3852088
cx3	Cd22^tm1Eac/Cd22⁺ Lyn^tm1Ard/Lyn⁺ Ptpn6^me-v/Ptpn6⁺ Tg(IghelMD4)4Ccg/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3852089
cx4	Cd22^tm1Eac/Cd22⁺ Ptpn6^me-v/Ptpn6⁺ Tg(IghelMD4)4Ccg/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3852090
cx5	Cd22^tm1Eac/Cd22⁺ Lyn^tm1Ard/Lyn⁺ Tg(IghelMD4)4Ccg/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3852091

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased B cell apoptosis ( J:132991 )

• B cells have less viability in co-cultures with dendritic cells compared to controls

abnormal transitional stage B cell morphology ( J:132991 )

• T1 B cell numbers in the spleen are slightly elevated

• T2 follicular and marginal zone precursors are reduced by 65% and 87%, respectively

decreased mature B cell number ( J:37451 , J:132991 )

• mature B cell numbers are reduced more than 3-fold in the bone marrow (J:37451)

• less mature B cells are found in the bone marrow (J:132991)

abnormal mature B cell morphology ( J:37451 )

• splenic B cells have decreased expression of sIgM and MHC-II

decreased marginal zone B cell number ( J:132991 )

• marginal zone B cell numbers are reduced by about half

decreased memory B cell number ( J:37451 )

• there is a virtual absent of long lived B cells found in the bone marrow and is reduced in the spleen

abnormal B cell activation ( J:37451 )

• B cells are about 10-fold more sensitive to BCR engagement based on mobilization of intracellular calcium

abnormal B cell proliferation ( J:37451 , J:132991 )

• B cells have less proliferative response to BCR cross-linking but have enhanced proliferative response to LPS (J:37451)

• less proliferation to BCR cross-linking is associated with increased rates of apoptosis and decreased progress in the cell cycle (J:37451)

• B cells proliferation is not inhibited by the presence of immature wild-type dendritic cells (J:132991)

decreased IgG1 level ( J:37451 )

• reduced levels of antigen-specific IgG1 occur after immunization with a T cell-independent type II antigen

decreased IgG3 level ( J:37451 )

• reduced levels of antigen-specific IgG3 occur after immunization with a T cell-independent type II antigen

decreased IgM level ( J:37451 )

• reduced levels of antigen-specific IgM occur after immunization with a T cell-independent type II antigen

hematopoietic system

increased B cell apoptosis ( J:132991 )

• B cells have less viability in co-cultures with dendritic cells compared to controls

abnormal transitional stage B cell morphology ( J:132991 )

• T1 B cell numbers in the spleen are slightly elevated

• T2 follicular and marginal zone precursors are reduced by 65% and 87%, respectively

decreased mature B cell number ( J:37451 , J:132991 )

• mature B cell numbers are reduced more than 3-fold in the bone marrow (J:37451)

• less mature B cells are found in the bone marrow (J:132991)

decreased marginal zone B cell number ( J:132991 )

• marginal zone B cell numbers are reduced by about half

decreased memory B cell number ( J:37451 )

• there is a virtual absent of long lived B cells found in the bone marrow and is reduced in the spleen

abnormal mature B cell morphology ( J:37451 )

• splenic B cells have decreased expression of sIgM and MHC-II

abnormal B cell activation ( J:37451 )

• B cells are about 10-fold more sensitive to BCR engagement based on mobilization of intracellular calcium

abnormal B cell proliferation ( J:37451 , J:132991 )

• B cells have less proliferative response to BCR cross-linking but have enhanced proliferative response to LPS (J:37451)

• less proliferation to BCR cross-linking is associated with increased rates of apoptosis and decreased progress in the cell cycle (J:37451)

• B cells proliferation is not inhibited by the presence of immature wild-type dendritic cells (J:132991)

decreased IgG1 level ( J:37451 )

• reduced levels of antigen-specific IgG1 occur after immunization with a T cell-independent type II antigen

decreased IgG3 level ( J:37451 )

• reduced levels of antigen-specific IgG3 occur after immunization with a T cell-independent type II antigen

decreased IgM level ( J:37451 )

• reduced levels of antigen-specific IgM occur after immunization with a T cell-independent type II antigen

cellular

increased B cell apoptosis ( J:132991 )

• B cells have less viability in co-cultures with dendritic cells compared to controls

abnormal B cell proliferation ( J:37451 , J:132991 )

• B cells have less proliferative response to BCR cross-linking but have enhanced proliferative response to LPS (J:37451)

• less proliferation to BCR cross-linking is associated with increased rates of apoptosis and decreased progress in the cell cycle (J:37451)

• B cells proliferation is not inhibited by the presence of immature wild-type dendritic cells (J:132991)

Allelic Composition	Cd22^tm1Eac/Cd22⁺ Tg(IghelMD4)4Ccg/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22^tm1Eac mutation (1 available); any Cd22 mutation (64 available)
Tg(IghelMD4)4Ccg mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal mature B cell morphology ( J:110531 )

• expression of CD22 on the surface of cells is half that of controls

• surface expression of IgM is about 70-80% of controls

hematopoietic system

abnormal mature B cell morphology ( J:110531 )

• expression of CD22 on the surface of cells is half that of controls

• surface expression of IgM is about 70-80% of controls

Allelic Composition	Cd22^tm1Eac/Cd22⁺ Lyn^tm1Ard/Lyn⁺ Ptpn6^me-v/Ptpn6⁺ Tg(IghelMD4)4Ccg/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22^tm1Eac mutation (1 available); any Cd22 mutation (64 available)
Lyn^tm1Ard mutation (6 available); any Lyn mutation (65 available)
Ptpn6^me-v mutation (3 available); any Ptpn6 mutation (49 available)
Tg(IghelMD4)4Ccg mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell negative selection ( J:110531 )

• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is almost completely blocked at the immature B cell stage

abnormal mature B cell morphology ( J:110531 )

• surface expression of IgM is only 15% of controls

increased IgM level ( J:110531 )

• half the mice have a 15-fold increase in Hel-specific serum IgM

hematopoietic system

abnormal B cell negative selection ( J:110531 )

• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is almost completely blocked at the immature B cell stage

abnormal mature B cell morphology ( J:110531 )

• surface expression of IgM is only 15% of controls

increased IgM level ( J:110531 )

• half the mice have a 15-fold increase in Hel-specific serum IgM

Allelic Composition	Cd22^tm1Eac/Cd22⁺ Ptpn6^me-v/Ptpn6⁺ Tg(IghelMD4)4Ccg/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22^tm1Eac mutation (1 available); any Cd22 mutation (64 available)
Ptpn6^me-v mutation (3 available); any Ptpn6 mutation (49 available)
Tg(IghelMD4)4Ccg mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell negative selection ( J:110531 )

• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is partially blocked at the immature B cell stage

abnormal mature B cell morphology ( J:110531 )

• surface expression of IgM is less than half of controls

hematopoietic system

abnormal B cell negative selection ( J:110531 )

• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is partially blocked at the immature B cell stage

abnormal mature B cell morphology ( J:110531 )

• surface expression of IgM is less than half of controls

Allelic Composition	Cd22^tm1Eac/Cd22⁺ Lyn^tm1Ard/Lyn⁺ Tg(IghelMD4)4Ccg/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell negative selection ( J:110531 )

• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is patially blocked at the immature B cell stage

abnormal mature B cell morphology ( J:110531 )

• surface expression of IgM is less than half of controls

hematopoietic system

abnormal B cell negative selection ( J:110531 )

• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is patially blocked at the immature B cell stage

abnormal mature B cell morphology ( J:110531 )

• surface expression of IgM is less than half of controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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