All Phenotypes Cxcr3<tm1Wwh> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cxcr3^tm1Wwh/Cxcr3^tm1Wwh	B6.Cg-Cxcr3^tm1Wwh	MGI:3694964
hm2	Cxcr3^tm1Wwh/Cxcr3^tm1Wwh	Not Specified	MGI:4830341
cx3	Cxcr3^tm1Wwh/Y Tg(TRAMP)8247Ng/?	involves: C57BL/6	MGI:3694967
ot4	Cxcr3^tm1Wwh/Y	B6.Cg-Cxcr3^tm1Wwh	MGI:3694965

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:96905 )

• most survive infection with lymphocytic choriomeningitis virus which is cleared in 1 month in survivors, controls do not survive

immune system

impaired macrophage chemotaxis ( J:107646 )

• 45% decrease of monocyte/macrophage in ischemic calf and thigh muscle

abnormal cellular extravasation ( J:96905 , J:107646 )

• reduced numbers of CD8+ cells in the brain 7 days after infection with lymphocytic choriomeningitis (J:96905)

• restricted to meninges and choroids plexus until late in infection unlike controls where white matter of the brain near ventricular surfaces will be penetrated by CD8+ cells (J:96905)

• 38% decrease in numbers of CD3+ T cells in ischemic calf and thigh muscles at 7 days but not at 21 days after ischemia (J:107646)

abnormal interferon level ( J:91359 )

• increased levels of IFN-gamma in lung tissue and in bronchoalveolar lavage 1 day after treatment with bleomycin, effect dissipates after 3 days

lung inflammation ( J:91359 )

• decreased total lymphocyte counts in bronchoalveolar lavage after bleomycin injury

• reduced numbers of CD8+ T cells after bleomycin injury

• reduced numbers of NK cells at day 7 after bleomycin injury, but also in the lungs of unchallenged mice

decreased susceptibility to Riboviria infection ( J:96905 )

• lack symptoms of infection at 7 days after infection with lymphocytic choriomeningitis virus

• less susceptibility to lymphocytic choriomeningitis virus

decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:96905 )

• most survive infection with lymphocytic choriomeningitis virus which is cleared in 1 month in survivors, controls do not survive

increased length of allograft survival ( J:65916 )

• increased cardiac allograft survival

• grafts with fewer Cd4+ and Cd8+ T cells

respiratory system

lung inflammation ( J:91359 )

• decreased total lymphocyte counts in bronchoalveolar lavage after bleomycin injury

• reduced numbers of CD8+ T cells after bleomycin injury

• reduced numbers of NK cells at day 7 after bleomycin injury, but also in the lungs of unchallenged mice

pulmonary interstitial fibrosis ( J:91359 )

• more severe and extensive interstitial fibrosis in response to bleomycin injury

• increased collagen deposition by day 21

• 50% mortality

• treatment with exogenous IFN-gamma partially alleviates tissue fibrosis

cardiovascular system

abnormal physiological neovascularization ( J:107646 )

• ischemic capillary density relative to nonischemic density 1.4 fold lower than in controls

• poor recovery of blood flow after ischemia

homeostasis/metabolism

abnormal interferon level ( J:91359 )

• increased levels of IFN-gamma in lung tissue and in bronchoalveolar lavage 1 day after treatment with bleomycin, effect dissipates after 3 days

cellular

impaired macrophage chemotaxis ( J:107646 )

• 45% decrease of monocyte/macrophage in ischemic calf and thigh muscle

abnormal cellular extravasation ( J:96905 , J:107646 )

• reduced numbers of CD8+ cells in the brain 7 days after infection with lymphocytic choriomeningitis (J:96905)

• restricted to meninges and choroids plexus until late in infection unlike controls where white matter of the brain near ventricular surfaces will be penetrated by CD8+ cells (J:96905)

• 38% decrease in numbers of CD3+ T cells in ischemic calf and thigh muscles at 7 days but not at 21 days after ischemia (J:107646)

hematopoietic system

impaired macrophage chemotaxis ( J:107646 )

• 45% decrease of monocyte/macrophage in ischemic calf and thigh muscle

abnormal cellular extravasation ( J:96905 , J:107646 )

• reduced numbers of CD8+ cells in the brain 7 days after infection with lymphocytic choriomeningitis (J:96905)

• restricted to meninges and choroids plexus until late in infection unlike controls where white matter of the brain near ventricular surfaces will be penetrated by CD8+ cells (J:96905)

• 38% decrease in numbers of CD3+ T cells in ischemic calf and thigh muscles at 7 days but not at 21 days after ischemia (J:107646)

Allelic Composition	Cxcr3^tm1Wwh/Cxcr3^tm1Wwh
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr3^tm1Wwh mutation (1 available); any Cxcr3 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:163822 )

• B16 melenoma tumor growth is significantly faster compared with wild-type mice

Allelic Composition	Cxcr3^tm1Wwh/Y Tg(TRAMP)8247Ng/?
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr3^tm1Wwh mutation (1 available); any Cxcr3 mutation (14 available)
Tg(TRAMP)8247Ng mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor growth/size ( J:115957 )

• prostate tumors detectable earlier than in controls, by 10-15 weeks of age

• greater tumor mass than controls until about 20 weeks of age but not thereafter

Allelic Composition	Cxcr3^tm1Wwh/Y
Genetic Background	B6.Cg-Cxcr3^tm1Wwh

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr3^tm1Wwh mutation (1 available); any Cxcr3 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired macrophage chemotaxis ( J:107646 )

• 45% decrease of monocyte/macrophage in ischemic calf and thigh muscle

abnormal cellular extravasation ( J:107646 )

• 38% decrease in numbers of CD3+ T cells in ischemic calf and thigh muscles at 7 days but not at 21 days after ischemia

abnormal interferon level ( J:91359 )

• increased levels of IFN-gamma in lung tissue and in bronchoalveolar lavage 1 day after treatment with bleomycin, effect dissipates after 3 days

lung inflammation ( J:91359 )

• decreased total lymphocyte counts in bronchoalveolar lavage after bleomycin injury

• reduced numbers of CD8+ T cells after bleomycin injury

• reduced numbers of NK cells at day 7 after bleomycin injury, but also in the lungs of unchallenged mice

increased length of allograft survival ( J:65916 )

• increased cardiac allograft survival

• grafts with fewer Cd4+ and Cd8+ T cells

respiratory system

lung inflammation ( J:91359 )

• decreased total lymphocyte counts in bronchoalveolar lavage after bleomycin injury

• reduced numbers of CD8+ T cells after bleomycin injury

• reduced numbers of NK cells at day 7 after bleomycin injury, but also in the lungs of unchallenged mice

pulmonary interstitial fibrosis ( J:91359 )

• more severe and extensive interstitial fibrosis in response to bleomycin injury

• increased collagen deposition by day 21

• 50% mortality

• treatment with exogenous IFN-gamma partially alleviates tissue fibrosis

cardiovascular system

abnormal physiological neovascularization ( J:107646 )

• ischemic capillary density relative to nonischemic density 1.4 fold lower than in controls

• poor recovery of blood flow after ischemia

homeostasis/metabolism

abnormal interferon level ( J:91359 )

• increased levels of IFN-gamma in lung tissue and in bronchoalveolar lavage 1 day after treatment with bleomycin, effect dissipates after 3 days

cellular

impaired macrophage chemotaxis ( J:107646 )

• 45% decrease of monocyte/macrophage in ischemic calf and thigh muscle

abnormal cellular extravasation ( J:107646 )

• 38% decrease in numbers of CD3+ T cells in ischemic calf and thigh muscles at 7 days but not at 21 days after ischemia

hematopoietic system

impaired macrophage chemotaxis ( J:107646 )

• 45% decrease of monocyte/macrophage in ischemic calf and thigh muscle

abnormal cellular extravasation ( J:107646 )

• 38% decrease in numbers of CD3+ T cells in ischemic calf and thigh muscles at 7 days but not at 21 days after ischemia

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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