About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cd19tm1Tft
targeted mutation 1, Thomas F Tedder
MGI:2180685
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cd19tm1Tft/Cd19tm1Tft B6.Cg-Cd19tm1Tft MGI:5000457
hm2
Cd19tm1Tft/Cd19tm1Tft involves: 129 * C57BL/6 MGI:5000442
hm3
Cd19tm1Tft/Cd19tm1Tft involves: 129/Sv * C57BL/6 MGI:5000441
hm4
Cd19tm1Tft/Cd19tm1Tft Not Specified MGI:3814909
cx5
Cd19tm1Tft/Cd19tm1Tft
Lyntm1Sor/Lyntm1Sor
involves: 129S4/SvJaeSor * C57BL/6 MGI:5000444


Genotype
MGI:5000457
hm1
Allelic
Composition
Cd19tm1Tft/Cd19tm1Tft
Genetic
Background
B6.Cg-Cd19tm1Tft
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1Tft mutation (0 available); any Cd19 mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• B cells stimulated with hyaluronan, heparan sulfate, and HMBG1 exhibit reduced cytokine over-production (IL6, IL10, IFN-gamma, TNF, and MIP-2) compared with similarly treated wild-type cells
• in untreated and bleomycin-treated mice
• in untreated and bleomycin-treated mice
• in bleomycin-treated mice
• in bleomycin-treated mice
• in untreated and bleomycin-treated mice
• in bleomycin-treated mice
• in bleomycin-treated mice
• in bleomycin-treated mice
• in bleomycin-treated mice
• in bleomycin-treated mice
• in B cells stimulated with MOG and anti-CD40 antibodies
• in B cells stimulated with MOG and anti-CD40 antibodies
• MOG-treated mice exhibit increased histological score, more severe inflammation, increased CD8+ T cells, wider spread demyelination, decreased IgM and IgG anti-MOG antibody production, and a Th1 bias with increased IFN-gamma production compared with similarly treated wild-type mice
• adoptive transfer of B cells increased susceptibility to experimental autoimmune encephalomyelitis in recipient wild-type mice
• untreated and bleomycin-treated mice exhibit reduced anti-topoisomerase I, anti-U1-RNP, anti-ssDNA, anti-histone, anti-dsDNA autoantibodies compared with wild-type mice
• in untreated and bleomycin-treated mice

nervous system
• in MOG-treated mice

hematopoietic system
• B cells stimulated with hyaluronan, heparan sulfate, and HMBG1 exhibit reduced cytokine over-production (IL6, IL10, IFN-gamma, TNF, and MIP-2) compared with similarly treated wild-type cells
• in untreated and bleomycin-treated mice
• in untreated and bleomycin-treated mice
• in bleomycin-treated mice
• in bleomycin-treated mice
• in untreated and bleomycin-treated mice
• in bleomycin-treated mice

homeostasis/metabolism
• in bleomycin-treated mice
• in bleomycin-treated mice
• in bleomycin-treated mice
• in bleomycin-treated mice
• bleomycin-treated mice exhibit decreased dermal infiltration (mast cells, macrophages, T and B cells), dermal thickening, skin and lung fibrosis, cytokine overproduction in the skin and serum (IL4, IL6, IL10, IFN-gamma, TNF, and MIP-2), hyaluronan overproduction, and autoantibody production compared with similarly treated wild-type mice

integument
• bleomycin-treated mice exhibit reduced dermal thickening compared with similarly treated wild-type mice
• bleomycin-treated mice exhibit reduced skin fibrosis compared with similarly treated wild-type mice




Genotype
MGI:5000442
hm2
Allelic
Composition
Cd19tm1Tft/Cd19tm1Tft
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1Tft mutation (0 available); any Cd19 mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in response to BCR ligation or LPS stimulation
• circulating, splenic, peritoneal, and lymph node B cells are decreased compared to in wild-type mice but less significantly than in Lyntm1Sor homozygotes
• mice exhibit impaired primary and secondary IgM responses compared with wild-type mice
• after second immunization, mice exhibit modest IgG1 anti-DNP responses compared with wild-type mice

hematopoietic system
• in response to BCR ligation or LPS stimulation
• circulating, splenic, peritoneal, and lymph node B cells are decreased compared to in wild-type mice but less significantly than in Lyntm1Sor homozygotes

cellular
• in response to BCR ligation or LPS stimulation




Genotype
MGI:5000441
hm3
Allelic
Composition
Cd19tm1Tft/Cd19tm1Tft
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1Tft mutation (0 available); any Cd19 mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• following cecal ligation and puncture

immune system
• in the peritoneal lavage following cecal ligation and puncture
• in the peritoneal lavage following cecal ligation and puncture

homeostasis/metabolism
• following cecal ligation and puncture, mice exhibit decreased survival, decreased TNF levels in the peritoneal lavage, decreased neutrophil numbers in the peritoneal lavage, and increased bacteria in the peritoneal lavage compared with wild-type mice

hematopoietic system
• in the peritoneal lavage following cecal ligation and puncture




Genotype
MGI:3814909
hm4
Allelic
Composition
Cd19tm1Tft/Cd19tm1Tft
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1Tft mutation (0 available); any Cd19 mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in the spleen B cell numbers are reduced 55% compared to in wild-type mice and B cell numbers are also reduced in the lymph nodes
• the number of peritoneal IgM+ B220+ B cells is reduced 74% compared to in wild-type mice
• the overall frequency of CD5+ B cells is reduced compared to in wild-type mice
• in the peritoneum
• following inoculation with DNP-KLH, mice exhibit a modest (less than 10%) IgM and IgG response compared to wild type mice
• secondary challenge elicits a less than 30% IgM and IgG response compared to in wild-type mice
• following stimulation with LPS or IgM or IgM and IL4
• levels in unimmunized mice are 48% lower than in wild-type mice
• levels in unimmunized mice are 86% lower than in wild-type mice
• levels in unimmunized mice are 84% lower than in wild-type mice
• levels in unimmunized mice are 72% lower than in wild-type mice
• levels in unimmunized mice are 57% lower than in wild-type mice
• levels in unimmunized mice are 75% lower than in wild-type mice

hematopoietic system
• in the spleen B cell numbers are reduced 55% compared to in wild-type mice and B cell numbers are also reduced in the lymph nodes
• the number of peritoneal IgM+ B220+ B cells is reduced 74% compared to in wild-type mice
• the overall frequency of CD5+ B cells is reduced compared to in wild-type mice
• in the peritoneum
• following inoculation with DNP-KLH, mice exhibit a modest (less than 10%) IgM and IgG response compared to wild type mice
• secondary challenge elicits a less than 30% IgM and IgG response compared to in wild-type mice
• following stimulation with LPS or IgM or IgM and IL4
• levels in unimmunized mice are 48% lower than in wild-type mice
• levels in unimmunized mice are 86% lower than in wild-type mice
• levels in unimmunized mice are 84% lower than in wild-type mice
• levels in unimmunized mice are 72% lower than in wild-type mice
• levels in unimmunized mice are 57% lower than in wild-type mice
• levels in unimmunized mice are 75% lower than in wild-type mice

cellular
• following stimulation with LPS or IgM or IgM and IL4




Genotype
MGI:5000444
cx5
Allelic
Composition
Cd19tm1Tft/Cd19tm1Tft
Lyntm1Sor/Lyntm1Sor
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1Tft mutation (0 available); any Cd19 mutation (60 available)
Lyntm1Sor mutation (2 available); any Lyn mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• IgA, IgM, and IgG levels are the same as in wild-type mice
• in response to BCR ligation or LPS stimulation
• but not as much as in Lyntm1Sor homozygotes
• bone marrow exhibit a modest decrease in IgM-B220low pro/pre B cells or IgM+ B220low immature B cells compared with wild-type mice
• circulating, splenic, peritoneal, and lymph node B cells are decreased compared to in wild-type mice
• bone marrow exhibit a decrease in IgM+ B220high compared with wild-type mice
• after immunization, anti-DNP IgM antibody production is delayed compared with wild-type mice
• IgG1 response is delayed and modest compared to in wild-type mice
• compared with Lyntm1Sor homozygotes
• compared with Lyntm1Sor homozygotes

hematopoietic system
• in response to BCR ligation or LPS stimulation
• but not as much as in Lyntm1Sor homozygotes
• bone marrow exhibit a modest decrease in IgM-B220low pro/pre B cells or IgM+ B220low immature B cells compared with wild-type mice
• circulating, splenic, peritoneal, and lymph node B cells are decreased compared to in wild-type mice
• bone marrow exhibit a decrease in IgM+ B220high compared with wild-type mice

cellular
• in response to BCR ligation or LPS stimulation

growth/size/body
• but not as much as in Lyntm1Sor homozygotes





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/19/2024
MGI 6.24
The Jackson Laboratory