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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd22tm1Lam
targeted mutation 1, Marinus C Lamers
MGI:2180698
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd22tm1Lam/Cd22tm1Lam involves: 129 * C57BL/6 MGI:3760846
cx2
 		Cd22tm1Lam/Cd22tm1Lam
Ightm1.2Rsky/Ightm1.2Rsky 		involves: 129 * BALB/c * C57BL/6 MGI:3760847
cx3
 		Cd22tm1Lam/Cd22tm1Lam
Ightm1.2Rsky/Igh+ 		involves: 129 * BALB/c * C57BL/6 MGI:3760862


Genotype
MGI:3760846
hm1
Allelic
Composition		 Cd22tm1Lam/Cd22tm1Lam
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22tm1Lam mutation (1 available); any Cd22 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased mature B cell number ( J:125719 )
• reduction of recirculating mature B cells in the bone marrow
abnormal B cell activation ( J:125719 )
• enhanced Ca2+ mobilization upon activation of B cells

hematopoietic system
decreased mature B cell number ( J:125719 )
• reduction of recirculating mature B cells in the bone marrow
abnormal B cell activation ( J:125719 )
• enhanced Ca2+ mobilization upon activation of B cells




Genotype
MGI:3760847
cx2
Allelic
Composition		 Cd22tm1Lam/Cd22tm1Lam
Ightm1.2Rsky/Ightm1.2Rsky
Genetic
Background		 involves: 129 * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22tm1Lam mutation (1 available); any Cd22 mutation (64 available)
Ightm1.2Rsky mutation (0 available); any Igh mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B-1a cell number ( J:125719 )
• 5 fold reduction in the peritoneum
abnormal B cell activation ( J:125719 )
• enhanced Ca2+ mobilization to high levels upon activation of B cells

hematopoietic system
decreased B-1a cell number ( J:125719 )
• 5 fold reduction in the peritoneum
abnormal B cell activation ( J:125719 )
• enhanced Ca2+ mobilization to high levels upon activation of B cells




Genotype
MGI:3760862
cx3
Allelic
Composition		 Cd22tm1Lam/Cd22tm1Lam
Ightm1.2Rsky/Igh+
Genetic
Background		 involves: 129 * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22tm1Lam mutation (1 available); any Cd22 mutation (64 available)
Ightm1.2Rsky mutation (0 available); any Igh mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal class switch recombination ( J:125719 )
• the percentage of B cells with surface IgG1 expression is doubled compared to mutant mice on a CD22-proficient background

hematopoietic system
abnormal class switch recombination ( J:125719 )
• the percentage of B cells with surface IgG1 expression is doubled compared to mutant mice on a CD22-proficient background




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory