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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd22tm1Tft
targeted mutation 1, Thomas F Tedder
MGI:2180700
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd22tm1Tft/Cd22tm1Tft involves: 129P2/OlaHsd * C57BL/6 MGI:3055138


Genotype
MGI:3055138
hm1
Allelic
Composition		 Cd22tm1Tft/Cd22tm1Tft
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22tm1Tft mutation (0 available); any Cd22 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased B cell proliferation ( J:92736 )
• B cell turnover is increased in all tissues
decreased B cell number ( J:92736 )
• the percentage of mature recirculating B cells, B cells in the blood, and marginal zone B cells are reduced however the number of B cells in the lymph nodes is increased

immune system
increased B cell proliferation ( J:92736 )
• B cell turnover is increased in all tissues
decreased B cell number ( J:92736 )
• the percentage of mature recirculating B cells, B cells in the blood, and marginal zone B cells are reduced however the number of B cells in the lymph nodes is increased

cellular
increased B cell proliferation ( J:92736 )
• B cell turnover is increased in all tissues




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory