Phenotypes associated with this allele

• Allele Symbol: Pik3cb^tm1Nbm
• Allele Name: targeted mutation 1, Robert L Nussbaum
• Allele ID: MGI:2180703
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pik3cb^tm1Nbm/Pik3cb^tm1Nbm	involves: 129S6/SvEvTac	MGI:2651930
cx2	Pik3ca^tm1Nbm/Pik3ca^+ Pik3cb^tm1Nbm/Pik3cb^+	involves: 129S6/SvEvTac	MGI:2651931

Genotype
MGI:2651930

hm1

• Allelic Composition: Pik3cb^tm1Nbm/Pik3cb^tm1Nbm
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Phase contrast microscopy of blastobysts flushed at day 3.5 d.p.c.

mortality/aging

embryonic lethality before implantation, incomplete penetrance ( J:75617 )

• number of viable embryos less than expected at E3.5

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:75617 )

• no viable embryos present at E8.5

Genotype
MGI:2651931

cx2

• Allelic Composition: Pik3ca^tm1Nbm/Pik3ca⁺; Pik3cb^tm1Nbm/Pik3cb⁺
• Genetic Background: involves: 129S6/SvEvTac

homeostasis/metabolism

increased circulating insulin level ( J:96761 )

• mild hyperinsulinemia in the fasted state at 6 months of age

impaired glucose tolerance ( J:96761 )

• mild glucose intolerance in glucose tolerance test at 6 months of age but not at early ages

• however, no differences seen in glucose clearance during an insulin tolerance test