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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd1d1tm1Luc
targeted mutation 1, Luc Van Kaer
MGI:2180711
Summary 6 genotypes


Genotype
MGI:3765456
hm1
Allelic
Composition		 Cd1d1tm1Luc/Cd1d1tm1Luc
Genetic
Background		 B6.129S6-Cd1d1tm1Luc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm1Luc mutation (2 available); any Cd1d1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased regulatory T cell number ( J:122245 )
• unlike in wild-type mice, treatment with alpha-GalCer fails to elicit an expansion of regulatory T cells following induction of experimental autoimmune myasthenia gravis
autoimmune response ( J:122245 )
• unlike in wild-type mice, treatment with alpha-GalCer fails to protect mice from experimental autoimmune myasthenia gravis

hematopoietic system
decreased regulatory T cell number ( J:122245 )
• unlike in wild-type mice, treatment with alpha-GalCer fails to elicit an expansion of regulatory T cells following induction of experimental autoimmune myasthenia gravis




Genotype
MGI:4821477
hm2
Allelic
Composition		 Cd1d1tm1Luc/Cd1d1tm1Luc
Genetic
Background		 C.129S6-Cd1d1tm1Luc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm1Luc mutation (2 available); any Cd1d1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased blood urea nitrogen level ( J:121187 )
• BUN is elevated in pristane-inoculated mice
increased urine protein level ( J:121187 )
• proteinuria develops early and is more severe in pristane treated mice

renal/urinary system
increased urine protein level ( J:121187 )
• proteinuria develops early and is more severe in pristane treated mice
kidney inflammation ( J:121187 )
• T cells and macrophages are found in the kidney after pristane treatment
glomerulonephritis ( J:121187 )
• diffuse proliferative glomerulonephritis with fibrous crescents, glomerulosclerosis, tubular atrophy, and interstitial fibrosis in 50% of pristane treated mice
glomerulosclerosis ( J:121187 )
• in 50% of pristane treated mice
glomerular crescent ( J:121187 )
• fibrous crescents in 50% of pristane treated mice
renal interstitial fibrosis ( J:121187 )
• in 50% of pristane treated mice
renal tubule atrophy ( J:121187 )
• in 50% of pristane treated mice

immune system
increased IgG3 level ( J:121187 )
• serum levels of IgG3 isotype are significantly higher in pristane-injected mice compared to similarly treated wild-type
decreased interleukin-4 secretion ( J:121187 )
• T cells from pristane treated mice stimulated with anti-CD3 or Con A secrete less IL4
increased anti-nuclear antigen antibody level ( J:121187 )
• anti-ribosomal P Abs and anti-OJ (isoleucyl tRNA synthetase complex) Abs after pristane treatment
increased anti-double stranded DNA antibody level ( J:121187 )
• increased IgG anti-dsDNA Ab levels after pristane treatment
kidney inflammation ( J:121187 )
• T cells and macrophages are found in the kidney after pristane treatment
glomerulonephritis ( J:121187 )
• diffuse proliferative glomerulonephritis with fibrous crescents, glomerulosclerosis, tubular atrophy, and interstitial fibrosis in 50% of pristane treated mice

hematopoietic system
increased IgG3 level ( J:121187 )
• serum levels of IgG3 isotype are significantly higher in pristane-injected mice compared to similarly treated wild-type




Genotype
MGI:3765900
hm3
Allelic
Composition		 Cd1d1tm1Luc/Cd1d1tm1Luc
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm1Luc mutation (2 available); any Cd1d1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
arrested T cell differentiation ( J:125679 )
• alpha-GalCer-CD1d-reactive T cells are a blocked in their development before reaching the DPdull stage
decreased NK T cell number ( J:39748 )
• the percentages of natural T (NT) cells in the thymus, peripheral lymph nodes, and liver are reduced compared to in wild-type mice
• the percentage of CD4+ NK1.1 cells is reduced 10- to 20-fold while the number of CD4-CD8- NK1.1 cells is reduced 4- to 5-fold compared to in wild-type mice
• the percentage of NT cells in the peripheral lymphoid organs is reduced 3- to 5-fold while the percentage of CD4+CD8- NT cells is reduced 10-fold and the percentage CD4-CD8- NT cells is reduced 2-fold compared to in wild-type mice
• the percentage of CD4+CD8- NT cells is reduced 8-fold while the percentage of CD4-CD8- NT cells is reduced 2-fold compared to in wild-type mice
decreased interferon-gamma secretion ( J:39748 , J:93915 )
• mice produce 2- to 9-fold less interferon-gamma than wild-type mice in response to anti-CD3 antibody stimulation (J:39748)
• in the liver after concanavalin A injection (J:93915)
decreased interleukin-4 secretion ( J:39748 )
• splenocytes produce 9- to 25-fold less IL-4 than wild-type cells when stimulated with anti-CD3 antibodies
decreased tumor necrosis factor secretion ( J:93915 )
• in the liver after concanavalin A injection
decreased acute inflammation ( J:93915 )
• significantly reduced infiltration of neutrophiles into the liver after concanavalin A injection

hematopoietic system
arrested T cell differentiation ( J:125679 )
• alpha-GalCer-CD1d-reactive T cells are a blocked in their development before reaching the DPdull stage
decreased NK T cell number ( J:39748 )
• the percentages of natural T (NT) cells in the thymus, peripheral lymph nodes, and liver are reduced compared to in wild-type mice
• the percentage of CD4+ NK1.1 cells is reduced 10- to 20-fold while the number of CD4-CD8- NK1.1 cells is reduced 4- to 5-fold compared to in wild-type mice
• the percentage of NT cells in the peripheral lymphoid organs is reduced 3- to 5-fold while the percentage of CD4+CD8- NT cells is reduced 10-fold and the percentage CD4-CD8- NT cells is reduced 2-fold compared to in wild-type mice
• the percentage of CD4+CD8- NT cells is reduced 8-fold while the percentage of CD4-CD8- NT cells is reduced 2-fold compared to in wild-type mice

liver/biliary system
abnormal liver morphology ( J:93915 )
• considerably less liver damage induced by concanavalin A injection than in controls
• as measured by alanine transaminase levels

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:93915 )
• considerably less liver damage induced by concanavalin A injection than in controls
• as measured by alanine transaminase levels




Genotype
MGI:4834138
cx4
Allelic
Composition		 Cd1d1tm1Luc/Cd1d1tm1Luc
Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic
Background		 B6.129-Cd1d1tm1Luc Cx3cr1tm1Litt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm1Luc mutation (2 available); any Cd1d1 mutation (35 available)
Cx3cr1tm1Litt mutation (6 available); any Cx3cr1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK cell number ( J:129712 )
• following induction of experimental autoimmune encephalomyelitis (EAE), mice exhibit a similar reduction in NK1.1/TCRbeta- cells in the central nervous system observed in similarly treated Cx3cr1tm1Litt compared with similarly treated wild-type mice
increased susceptibility to experimental autoimmune encephalomyelitis ( J:129712 )
• mice exhibit the same severity of experimental autoimmune encephalomyelitis as Cx3cr1tm1Litt homozygotes

behavior/neurological
paralysis ( J:129712 )
• following induction of experimental autoimmune encephalomyelitis, mice exhibit nonremitting spastic paralysis

hematopoietic system
decreased NK cell number ( J:129712 )
• following induction of experimental autoimmune encephalomyelitis (EAE), mice exhibit a similar reduction in NK1.1/TCRbeta- cells in the central nervous system observed in similarly treated Cx3cr1tm1Litt compared with similarly treated wild-type mice




Genotype
MGI:4821420
cx5
Allelic
Composition		 Cd1d1tm1Luc/Cd1d1tm1Luc
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background		 B6.129S-Cd1d1tm1Luc Ldlrtm1Her
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm1Luc mutation (2 available); any Cd1d1 mutation (35 available)
Ldlrtm1Her mutation (19 available); any Ldlr mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased susceptibility to atherosclerosis ( J:110061 )
• male mice after 4 weeks on the Western diet have lesions of small fatty streaks on the aorta were 40.4% smaller than Ldlrtm1Her
• Oil red O stained serial sections of 4-week-old mice fed a western diet, revealed had 31.7% less lipid staining than Ldlrtm1Her

homeostasis/metabolism
decreased circulating VLDL cholesterol level ( J:110061 )
• slightly lower levels of very low density lipoprotein




Genotype
MGI:6094191
cx6
Allelic
Composition		 Cd1d1tm1Luc/Cd1d1tm1Luc
X/Yaa
Genetic
Background		 BXSB.129S6(B6)-Cd1d1tm1Luc/Dcr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm1Luc mutation (2 available); any Cd1d1 mutation (35 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:179430 )
• disruption of Cd1d1 does not alter the Yaa-induced premature death on this BXSB background, which causes a mean survival of 32 weeks of age in males




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory