About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cd1d1tm1Luc
targeted mutation 1, Luc Van Kaer
MGI:2180711
Summary 6 genotypes


Genotype
MGI:3765456
hm1
Allelic
Composition
Cd1d1tm1Luc/Cd1d1tm1Luc
Genetic
Background
B6.129S6-Cd1d1tm1Luc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm1Luc mutation (2 available); any Cd1d1 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• unlike in wild-type mice, treatment with alpha-GalCer fails to elicit an expansion of regulatory T cells following induction of experimental autoimmune myasthenia gravis
• unlike in wild-type mice, treatment with alpha-GalCer fails to protect mice from experimental autoimmune myasthenia gravis

hematopoietic system
• unlike in wild-type mice, treatment with alpha-GalCer fails to elicit an expansion of regulatory T cells following induction of experimental autoimmune myasthenia gravis




Genotype
MGI:4821477
hm2
Allelic
Composition
Cd1d1tm1Luc/Cd1d1tm1Luc
Genetic
Background
C.129S6-Cd1d1tm1Luc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm1Luc mutation (2 available); any Cd1d1 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• BUN is elevated in pristane-inoculated mice
• proteinuria develops early and is more severe in pristane treated mice

renal/urinary system
• proteinuria develops early and is more severe in pristane treated mice
• T cells and macrophages are found in the kidney after pristane treatment
• diffuse proliferative glomerulonephritis with fibrous crescents, glomerulosclerosis, tubular atrophy, and interstitial fibrosis in 50% of pristane treated mice
• in 50% of pristane treated mice
• fibrous crescents in 50% of pristane treated mice
• in 50% of pristane treated mice
• in 50% of pristane treated mice

immune system
• serum levels of IgG3 isotype are significantly higher in pristane-injected mice compared to similarly treated wild-type
• T cells from pristane treated mice stimulated with anti-CD3 or Con A secrete less IL4
• anti-ribosomal P Abs and anti-OJ (isoleucyl tRNA synthetase complex) Abs after pristane treatment
• increased IgG anti-dsDNA Ab levels after pristane treatment
• T cells and macrophages are found in the kidney after pristane treatment
• diffuse proliferative glomerulonephritis with fibrous crescents, glomerulosclerosis, tubular atrophy, and interstitial fibrosis in 50% of pristane treated mice

hematopoietic system
• serum levels of IgG3 isotype are significantly higher in pristane-injected mice compared to similarly treated wild-type




Genotype
MGI:3765900
hm3
Allelic
Composition
Cd1d1tm1Luc/Cd1d1tm1Luc
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm1Luc mutation (2 available); any Cd1d1 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• alpha-GalCer-CD1d-reactive T cells are a blocked in their development before reaching the DPdull stage
• the percentages of natural T (NT) cells in the thymus, peripheral lymph nodes, and liver are reduced compared to in wild-type mice
• the percentage of CD4+ NK1.1 cells is reduced 10- to 20-fold while the number of CD4-CD8- NK1.1 cells is reduced 4- to 5-fold compared to in wild-type mice
• the percentage of NT cells in the peripheral lymphoid organs is reduced 3- to 5-fold while the percentage of CD4+CD8- NT cells is reduced 10-fold and the percentage CD4-CD8- NT cells is reduced 2-fold compared to in wild-type mice
• the percentage of CD4+CD8- NT cells is reduced 8-fold while the percentage of CD4-CD8- NT cells is reduced 2-fold compared to in wild-type mice
• mice produce 2- to 9-fold less interferon-gamma than wild-type mice in response to anti-CD3 antibody stimulation (J:39748)
• in the liver after concanavalin A injection (J:93915)
• splenocytes produce 9- to 25-fold less IL-4 than wild-type cells when stimulated with anti-CD3 antibodies
• in the liver after concanavalin A injection
• significantly reduced infiltration of neutrophiles into the liver after concanavalin A injection

hematopoietic system
• alpha-GalCer-CD1d-reactive T cells are a blocked in their development before reaching the DPdull stage
• the percentages of natural T (NT) cells in the thymus, peripheral lymph nodes, and liver are reduced compared to in wild-type mice
• the percentage of CD4+ NK1.1 cells is reduced 10- to 20-fold while the number of CD4-CD8- NK1.1 cells is reduced 4- to 5-fold compared to in wild-type mice
• the percentage of NT cells in the peripheral lymphoid organs is reduced 3- to 5-fold while the percentage of CD4+CD8- NT cells is reduced 10-fold and the percentage CD4-CD8- NT cells is reduced 2-fold compared to in wild-type mice
• the percentage of CD4+CD8- NT cells is reduced 8-fold while the percentage of CD4-CD8- NT cells is reduced 2-fold compared to in wild-type mice

liver/biliary system
• considerably less liver damage induced by concanavalin A injection than in controls
• as measured by alanine transaminase levels

homeostasis/metabolism
• considerably less liver damage induced by concanavalin A injection than in controls
• as measured by alanine transaminase levels




Genotype
MGI:4834138
cx4
Allelic
Composition
Cd1d1tm1Luc/Cd1d1tm1Luc
Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic
Background
B6.129-Cd1d1tm1Luc Cx3cr1tm1Litt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm1Luc mutation (2 available); any Cd1d1 mutation (35 available)
Cx3cr1tm1Litt mutation (6 available); any Cx3cr1 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following induction of experimental autoimmune encephalomyelitis (EAE), mice exhibit a similar reduction in NK1.1/TCRbeta- cells in the central nervous system observed in similarly treated Cx3cr1tm1Litt compared with similarly treated wild-type mice
• mice exhibit the same severity of experimental autoimmune encephalomyelitis as Cx3cr1tm1Litt homozygotes

behavior/neurological
• following induction of experimental autoimmune encephalomyelitis, mice exhibit nonremitting spastic paralysis

hematopoietic system
• following induction of experimental autoimmune encephalomyelitis (EAE), mice exhibit a similar reduction in NK1.1/TCRbeta- cells in the central nervous system observed in similarly treated Cx3cr1tm1Litt compared with similarly treated wild-type mice




Genotype
MGI:4821420
cx5
Allelic
Composition
Cd1d1tm1Luc/Cd1d1tm1Luc
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background
B6.129S-Cd1d1tm1Luc Ldlrtm1Her
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm1Luc mutation (2 available); any Cd1d1 mutation (35 available)
Ldlrtm1Her mutation (19 available); any Ldlr mutation (81 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• male mice after 4 weeks on the Western diet have lesions of small fatty streaks on the aorta were 40.4% smaller than Ldlrtm1Her
• Oil red O stained serial sections of 4-week-old mice fed a western diet, revealed had 31.7% less lipid staining than Ldlrtm1Her

homeostasis/metabolism
• slightly lower levels of very low density lipoprotein




Genotype
MGI:6094191
cx6
Allelic
Composition
Cd1d1tm1Luc/Cd1d1tm1Luc
X/Yaa
Genetic
Background
BXSB.129S6(B6)-Cd1d1tm1Luc/Dcr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm1Luc mutation (2 available); any Cd1d1 mutation (35 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• disruption of Cd1d1 does not alter the Yaa-induced premature death on this BXSB background, which causes a mean survival of 32 weeks of age in males





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory