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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd1d1tm1Crw
targeted mutation 1, Chyung-Ru Wang
MGI:2180713
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd1d1tm1Crw/Cd1d1tm1Crw B6.129S4-Cd1d1tm1Crw MGI:3722106
hm2
 		Cd1d1tm1Crw/Cd1d1tm1Crw involves: 129S4/SvJae * C57BL/6 MGI:3722100


Genotype
MGI:3722106
hm1
Allelic
Composition		 Cd1d1tm1Crw/Cd1d1tm1Crw
Genetic
Background		 B6.129S4-Cd1d1tm1Crw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm1Crw mutation (0 available); any Cd1d1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgG level ( J:99107 )
• levels of anti CII IgG antibodies are reduced compared to in wild-type mice
decreased susceptibility to induced arthritis ( J:99107 )
• following induction of arthritis with collagen (CIA) the incidence (40%) and arthritis score (2.0+/-2.7) is reduced compared to wild-type mice (90% incidence with a score of 5.4+/-3.2)

skeleton
decreased susceptibility to induced arthritis ( J:99107 )
• following induction of arthritis with collagen (CIA) the incidence (40%) and arthritis score (2.0+/-2.7) is reduced compared to wild-type mice (90% incidence with a score of 5.4+/-3.2)

hematopoietic system
decreased IgG level ( J:99107 )
• levels of anti CII IgG antibodies are reduced compared to in wild-type mice




Genotype
MGI:3722100
hm2
Allelic
Composition		 Cd1d1tm1Crw/Cd1d1tm1Crw
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm1Crw mutation (0 available); any Cd1d1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK T cell number ( J:76976 )
• the percentage of NK T cells in the liver is reduced by 70% to 75% and by 60% to 75% in all other organs tested

hematopoietic system
decreased NK T cell number ( J:76976 )
• the percentage of NK T cells in the liver is reduced by 70% to 75% and by 60% to 75% in all other organs tested




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory