All Phenotypes Aldh1a2<tm1Gdu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Aldh1a2^tm1Gdu
targeted mutation 1, Gregg Duester
MGI:2180721

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aldh1a2^tm1Gdu/Aldh1a2^tm1Gdu	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:2180875
hm2	Aldh1a2^tm1Gdu/Aldh1a2^tm1Gdu	involves: 129S1/Sv * 129X1/SvJ * Swiss Webster	MGI:4431233
cx3	Aldh1a2^tm1Gdu/Aldh1a2^tm1Gdu Aldh1a3^tm1Gdu/Aldh1a3^tm1Gdu	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3718031
cx4	Aldh1a1^tm1Gdu/Aldh1a1^tm1Gdu Aldh1a2^tm1Gdu/Aldh1a2^tm1Gdu Aldh1a3^tm1Gdu/Aldh1a3^tm1Gdu	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3718030
cx5	Aldh1a2^tm1Gdu/Aldh1a2^tm1Gdu Tg(Hoxb7-EGFP)33Cos/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * Swiss Webster	MGI:4431234
cx6	Aldh1a2^tm1Gdu/Aldh1a2^tm1Gdu Aldh1a3^tm1Gdu/Aldh1a3^tm1Gdu	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * Swiss Webster	MGI:4431236

Allelic Composition	Aldh1a2^tm1Gdu/Aldh1a2^tm1Gdu
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldh1a2^tm1Gdu mutation (1 available); any Aldh1a2 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:75950 )

• embryos survive until E10.5, but are being resorbed by E11.5

cardiovascular system

abnormal heart development ( J:75950 )

• abnormal heart chamber morphogenesis

failure of heart looping ( J:75950 )

• failure of heart looping

embryo

absent second pharyngeal arch ( J:75950 )

• lack of branchial arches 2 and 3

absent third pharyngeal arch ( J:75950 )

• lack of branchial arches 2 and 3

• however, the first arches are intact

decreased embryo size ( J:75950 )

• smaller than littermates after E8.75

decreased somite size ( J:75950 )

• small somites

hearing/vestibular/ear

small otic vesicle ( J:75950 )

• small otic vesicles

growth/size/body

decreased embryo size ( J:75950 )

• smaller than littermates after E8.75

decreased body length ( J:75950 )

• short trunk

craniofacial

absent second pharyngeal arch ( J:75950 )

• lack of branchial arches 2 and 3

absent third pharyngeal arch ( J:75950 )

• lack of branchial arches 2 and 3

• however, the first arches are intact

Allelic Composition	Aldh1a2^tm1Gdu/Aldh1a2^tm1Gdu
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldh1a2^tm1Gdu mutation (1 available); any Aldh1a2 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal hypoplasia ( J:157254 )

• greatly reduced in size with relatively normal architecture by E14.5

• normal branching at E12.5

• mutants are treated with a small amount of retinoic acid to the maternal diet between E7 and E9 to bypass lethality due to heart defects

Allelic Composition	Aldh1a2^tm1Gdu/Aldh1a2^tm1Gdu Aldh1a3^tm1Gdu/Aldh1a3^tm1Gdu
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldh1a2^tm1Gdu mutation (1 available); any Aldh1a2 mutation (36 available)
Aldh1a3^tm1Gdu mutation (1 available); any Aldh1a3 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal optic cup morphology ( J:108515 )

• failure of ventral invagination of the optic vesicle at the point that defines the junction of the ventral retina and optic stalk is seen at E10.5 and E11.5 following maternal dietary retinoic acid treatment ending at E8.5

Allelic Composition	Aldh1a1^tm1Gdu/Aldh1a1^tm1Gdu Aldh1a2^tm1Gdu/Aldh1a2^tm1Gdu Aldh1a3^tm1Gdu/Aldh1a3^tm1Gdu
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldh1a1^tm1Gdu mutation (1 available); any Aldh1a1 mutation (37 available)
Aldh1a2^tm1Gdu mutation (1 available); any Aldh1a2 mutation (36 available)
Aldh1a3^tm1Gdu mutation (1 available); any Aldh1a3 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal optic cup morphology ( J:108515 )

• at E10.5 the ventral optic vesicle has not invaginated to form a complete optic cup following maternal dietary retinoic acid treatment ending at E8.5

• however, dorsal invagination does occur

Allelic Composition	Aldh1a2^tm1Gdu/Aldh1a2^tm1Gdu Tg(Hoxb7-EGFP)33Cos/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldh1a2^tm1Gdu mutation (1 available); any Aldh1a2 mutation (36 available)
Tg(Hoxb7-EGFP)33Cos mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

impaired branching involved in ureteric bud morphogenesis ( J:157254 )

• 50% reduction in branch numbers at E18 and earlier stages

Allelic Composition	Aldh1a2^tm1Gdu/Aldh1a2^tm1Gdu Aldh1a3^tm1Gdu/Aldh1a3^tm1Gdu
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * Swiss Webster

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal hypoplasia ( J:157254 )

• greatly reduced in size compared with homozygous Aldh1a2^tm1Gdu mice at E14

impaired branching involved in ureteric bud morphogenesis ( J:157254 )

• contain few ureteric bud branches or developing nephrons at E14

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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