Phenotypes associated with this allele

• Allele Symbol: Maob^tm1Shih
• Allele Name: targeted mutation 1, Jean C Shih
• Allele ID: MGI:2180752
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Maob^tm1Shih/Maob^tm1Shih	either: (involves: 129S/SvEv) or (involves: 129S4/SvJae)	MGI:3042587
cx2	Maoa^K284stopMaob^tm1Shih/Y	either: (involves: 129S/SvEv * 129S6/SvEvTac) or (involves: 129S4/SvJae * 129S6/SvEvTac)	MGI:3511894

Genotype
MGI:3042587

hm1

• Allelic Composition: Maob^tm1Shih/Maob^tm1Shih
• Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S4/SvJae)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:43648 )

♀N • mutant mice displayed normal working memory in a Y maize test, and exhibited no significant alteration in the open-field test or the elevated plus maize test relative to wild-type

increased locomotor activity ( J:43648 )

♀ • mutants exhibited significantly increased mobility in the forced swim test, suggesting a state of hyperactivity and increased vigilance to stress

♀ • mutants showed no adaptation to inescapable stress, indicating a sustained stress-induced hyperactivity

♀ • notably, mutants did not display increased locomotion in the open field test

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:43648 )

♀N • mutant mice displayed normal concentrations of 5-HT, 5-hydroxy-3-indole-acetic acid (5-HIAA), dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), 3-methoxytyramine (3-MT), norepinephrine (NE) and 3-methoxy-4-hydroxy-phenylglycol (MHPG) in various brain regions relative to wild-type

decreased susceptibility to dopaminergic neuron neurotoxicity ( J:43648 )

♀ • MPTP neurotoxicity resulted in the depletion of DA, DOPAC and possibly HVA in wild-type mice; in contrast, mutants suffered no apparent MPTP toxicity of dopaminergic terminals in the striatum

abnormal urine homeostasis ( J:43648 )

♀ • urinary beta-phenylethylamine (PEA) excretion showed an 8-fold increase in mutant mice relative to wild-type; notably, brain levels of PEA were also increased ~8-fold

renal/urinary system

abnormal urine homeostasis ( J:43648 )

♀ • urinary beta-phenylethylamine (PEA) excretion showed an 8-fold increase in mutant mice relative to wild-type; notably, brain levels of PEA were also increased ~8-fold

nervous system

decreased susceptibility to dopaminergic neuron neurotoxicity ( J:43648 )

♀ • MPTP neurotoxicity resulted in the depletion of DA, DOPAC and possibly HVA in wild-type mice; in contrast, mutants suffered no apparent MPTP toxicity of dopaminergic terminals in the striatum

cellular

decreased susceptibility to dopaminergic neuron neurotoxicity ( J:43648 )

♀ • MPTP neurotoxicity resulted in the depletion of DA, DOPAC and possibly HVA in wild-type mice; in contrast, mutants suffered no apparent MPTP toxicity of dopaminergic terminals in the striatum

Genotype
MGI:3511894

cx2

• Allelic Composition: Maoa^K284stopMaob^tm1Shih/Y
• Genetic Background: either: (involves: 129S/SvEv * 129S6/SvEvTac) or (involves: 129S4/SvJae * 129S6/SvEvTac)

behavior/neurological

decreased exploration in new environment ( J:93356 )

♂ • exploratory activity is reduced as is time spent in the center of the field

increased aggression towards mice ( J:93356 )

♂ • in the resident-intruder test mutants display a significant increase in anti-social behavior with a decrease in latency to attack and increased time spent chasing the intruder, as well as a decrease in investigative behavior

increased anxiety-related response ( J:93356 )

♂ • in an elevated Plus-maze, mutants exhibit more freezing or crouching postures, fewer entries into either the open or closed arms, proportionally more entries into the closed arms, and fewer rearing events

homeostasis/metabolism

increased dopamine level ( J:93356 )

♂ • dopamine levels are increased 1.7-fold

increased noradrenaline level ( J:93356 )

♂ • brain levels of norepinephrine and phenylethylamine are increased 2.2-, and 15.7-fold, respectively

increased serotonin level ( J:93356 )

♂ • brain levels of serotonin are increased 8.5-fold